AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:08:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACVR1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rw8.
| PDB = {{PDB2|1rw8}}
| Name = Activin A receptor, type IB
| HGNCid = 172
| Symbol = ACVR1B
| AltSymbols =; ACTRIB; ACVRLK4; ALK4; SKR2
| OMIM = 601300
| ECnumber =
| Homologene = 20906
| MGIid = 1338944
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016361 |text = activin receptor activity, type I}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0048185 |text = activin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001942 |text = hair follicle development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045648 |text = positive regulation of erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 91
| Hs_Ensembl = ENSG00000135503
| Hs_RefseqProtein = NP_004293
| Hs_RefseqmRNA = NM_004302
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50494095
| Hs_GenLoc_end = 50677124
| Hs_Uniprot = P36896
| Mm_EntrezGene = 11479
| Mm_Ensembl = ENSMUSG00000000532
| Mm_RefseqmRNA = NM_007395
| Mm_RefseqProtein = NP_031421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101002159
| Mm_GenLoc_end = 101040635
| Mm_Uniprot = Q3TZF1
}}
}}
'''Activin A receptor, type IB''', also known as '''ACVR1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.<ref>{{cite web | title = Entrez Gene: ACVR1B activin A receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317-23 |year= 2002 |pmid= 12032389 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CACNA1H... {November 10, 2007 10:35:02 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:35:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcium channel, voltage-dependent, T type, alpha 1H subunit
| HGNCid = 1395
| Symbol = CACNA1H
| AltSymbols =; CACNA1HB; Cav3.2; FLJ90484
| OMIM = 607904
| ECnumber =
| Homologene = 56913
| MGIid = 1928842
| GeneAtlas_image1 = PBB_GE_CACNA1H_205845_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008332 |text = low voltage-gated calcium channel activity}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007520 |text = myoblast fusion}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8912
| Hs_Ensembl = ENSG00000196557
| Hs_RefseqProtein = NP_001005407
| Hs_RefseqmRNA = NM_001005407
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 1143739
| Hs_GenLoc_end = 1211772
| Hs_Uniprot = O95180
| Mm_EntrezGene = 58226
| Mm_Ensembl = ENSMUSG00000024112
| Mm_RefseqmRNA = NM_021415
| Mm_RefseqProtein = NP_067390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 25101887
| Mm_GenLoc_end = 25161385
| Mm_Uniprot = Q6PE92
}}
}}
'''Calcium channel, voltage-dependent, T type, alpha 1H subunit''', also known as '''CACNA1H''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).<ref>{{cite web | title = Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Crunelli V, Tóth TI, Cope DW, ''et al.'' |title=The 'window' T-type calcium current in brain dynamics of different behavioural states. |journal=J. Physiol. (Lond.) |volume=562 |issue= Pt 1 |pages= 121-9 |year= 2005 |pmid= 15498803 |doi= 10.1113/jphysiol.2004.076273 }}
*{{cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411-25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on COIL... {November 10, 2007 10:31:30 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:32:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coilin
| HGNCid = 2184
| Symbol = COIL
| AltSymbols =; CLN80; p80-coilin
| OMIM = 600272
| ECnumber =
| Homologene = 3413
| MGIid = 104842
| GeneAtlas_image1 = PBB_GE_COIL_203654_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COIL_203653_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001674 |text = female germ cell nucleus}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015030 |text = Cajal body}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8161
| Hs_Ensembl = ENSG00000121058
| Hs_RefseqProtein = NP_004636
| Hs_RefseqmRNA = NM_004645
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 52370562
| Hs_GenLoc_end = 52393410
| Hs_Uniprot = P38432
| Mm_EntrezGene = 12812
| Mm_Ensembl = ENSMUSG00000033983
| Mm_RefseqmRNA = NM_016706
| Mm_RefseqProtein = NP_057915
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 88790039
| Mm_GenLoc_end = 88807703
| Mm_Uniprot =
}}
}}
'''Coilin''', also known as '''COIL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.<ref>{{cite web | title = Entrez Gene: COIL coilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8161| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on COL4A6... {November 10, 2007 12:11:36 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:12:48 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 6
| HGNCid = 2208
| Symbol = COL4A6
| AltSymbols =; MGC88184
| OMIM = 303631
| ECnumber =
| Homologene = 48050
| MGIid = 2152695
| GeneAtlas_image1 = PBB_GE_COL4A6_211473_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A6_213992_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL4A6_210945_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1288
| Hs_Ensembl = ENSG00000197565
| Hs_RefseqProtein = NP_001838
| Hs_RefseqmRNA = NM_001847
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 107285493
| Hs_GenLoc_end = 107569383
| Hs_Uniprot = Q14031
| Mm_EntrezGene = 94216
| Mm_Ensembl = ENSMUSG00000031273
| Mm_RefseqmRNA = NM_053185
| Mm_RefseqProtein = NP_444415
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 136412396
| Mm_GenLoc_end = 136720444
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 6''', also known as '''COL4A6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on MAP3K8... {November 10, 2007 12:12:48 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:13:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 8
| HGNCid = 6860
| Symbol = MAP3K8
| AltSymbols =; COT; EST; ESTF; FLJ10486; TPL2; Tpl-2; c-COT
| OMIM = 191195
| ECnumber =
| Homologene = 3812
| MGIid = 1346878
| GeneAtlas_image1 = PBB_GE_MAP3K8_205027_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1326
| Hs_Ensembl = ENSG00000107968
| Hs_RefseqProtein = NP_005195
| Hs_RefseqmRNA = NM_005204
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 30762872
| Hs_GenLoc_end = 30790768
| Hs_Uniprot = P41279
| Mm_EntrezGene = 26410
| Mm_Ensembl = ENSMUSG00000024235
| Mm_RefseqmRNA = NM_007746
| Mm_RefseqProtein = NP_031772
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 4331325
| Mm_GenLoc_end = 4352951
| Mm_Uniprot = Q3T9M0
}}
}}
'''Mitogen-activated protein kinase kinase kinase 8''', also known as '''MAP3K8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.<ref>{{cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on UCN... {November 10, 2007 10:26:00 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:26:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urocortin
| HGNCid = 12516
| Symbol = UCN
| AltSymbols =; MGC129974; MGC129975; UI; UROC
| OMIM = 600945
| ECnumber =
| Homologene = 2515
| MGIid = 1276123
| GeneAtlas_image1 = PBB_GE_UCN_206072_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7349
| Hs_Ensembl = ENSG00000163794
| Hs_RefseqProtein = NP_003344
| Hs_RefseqmRNA = NM_003353
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 27383769
| Hs_GenLoc_end = 27384634
| Hs_Uniprot = P55089
| Mm_EntrezGene = 22226
| Mm_Ensembl = ENSMUSG00000038676
| Mm_RefseqmRNA = NM_021290
| Mm_RefseqProtein = NP_067265
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 31414570
| Mm_GenLoc_end = 31415476
| Mm_Uniprot = Q14A76
}}
}}
'''Urocortin''', also known as '''UCN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref>{{cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on ZYX... {November 10, 2007 10:26:40 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:27:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zyxin
| HGNCid = 13200
| Symbol = ZYX
| AltSymbols =; ESP-2; HED-2
| OMIM = 602002
| ECnumber =
| Homologene = 31164
| MGIid = 103072
| GeneAtlas_image1 = PBB_GE_ZYX_200808_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZYX_215706_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7791
| Hs_Ensembl = ENSG00000159840
| Hs_RefseqProtein = NP_001010972
| Hs_RefseqmRNA = NM_001010972
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142788482
| Hs_GenLoc_end = 142798322
| Hs_Uniprot = Q15942
| Mm_EntrezGene = 22793
| Mm_Ensembl = ENSMUSG00000029860
| Mm_RefseqmRNA = NM_011777
| Mm_RefseqProtein = NP_035907
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 42279476
| Mm_GenLoc_end = 42289753
| Mm_Uniprot = Q62523
}}
}}
'''Zyxin''', also known as '''ZYX''', is a human [[gene]].
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| summary_text = Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.<ref>{{cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = }}</ref>
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==References==
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