Other Pages: Neurotensin (Protein Template); NTS (DisAmbig); NT (DisAmbig); Nt (Redirect -> NT); NMN-125 (No Data); Nmn-125 (No Data); NN (DisAmbig); Nn (Redirect -> NN); NTS1 (No Data); Nts1 (No Data);
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:24:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATXN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oa8.
| PDB = {{PDB2|1oa8}}
| Name = Ataxin 1
| HGNCid = 10548
| Symbol = ATXN1
| AltSymbols =; ATX1; D6S504E; SCA1
| OMIM = 601556
| ECnumber =
| Homologene = 281
| MGIid = 104783
| GeneAtlas_image1 = PBB_GE_ATXN1_203232_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATXN1_203231_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0042405 |text = nuclear inclusion body}}
| Process = {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6310
| Hs_Ensembl = ENSG00000124788
| Hs_RefseqProtein = NP_000323
| Hs_RefseqmRNA = NM_000332
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 16407320
| Hs_GenLoc_end = 16869703
| Hs_Uniprot = P54253
| Mm_EntrezGene = 20238
| Mm_Ensembl = ENSMUSG00000046876
| Mm_RefseqmRNA = NM_009124
| Mm_RefseqProtein = NP_033150
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 45565865
| Mm_GenLoc_end = 45975948
| Mm_Uniprot = Q8C866
}}
}}
'''Ataxin 1''', also known as '''ATXN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele. Several transcript variants in the 5' UTR have been described; however, their full-length nature is not known.<ref>{{cite web | title = Entrez Gene: ATXN1 ataxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6310| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stevanin G, Dürr A, Brice A |title=Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 1 |pages= 4-18 |year= 2000 |pmid= 10713882 |doi= 10.1038/sj.ejhg.5200403 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:09:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MYLK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cqv.
| PDB = {{PDB2|2cqv}}
| Name = Myosin, light chain kinase
| HGNCid = 7590
| Symbol = MYLK
| AltSymbols =; DKFZp686I10125; FLJ12216; KRP; MLCK; MLCK108; MLCK210; MSTP083
| OMIM = 600922
| ECnumber =
| Homologene = 14202
| MGIid = 894806
| GeneAtlas_image1 = PBB_GE_MYLK_202555_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004687 |text = myosin light chain kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4638
| Hs_Ensembl = ENSG00000065534
| Hs_RefseqProtein = NP_005956
| Hs_RefseqmRNA = NM_005965
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 124813835
| Hs_GenLoc_end = 125085839
| Hs_Uniprot = Q15746
| Mm_EntrezGene = 107589
| Mm_Ensembl = ENSMUSG00000022836
| Mm_RefseqmRNA = NM_139300
| Mm_RefseqProtein = NP_647461
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 34735182
| Mm_GenLoc_end = 34920279
| Mm_Uniprot = Q8CIY5
}}
}}
'''Myosin, light chain kinase''', also known as '''MYLK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.<ref>{{cite web | title = Entrez Gene: MYLK myosin, light chain kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4638| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kamm KE, Stull JT |title=Dedicated myosin light chain kinases with diverse cellular functions. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4527-30 |year= 2001 |pmid= 11096123 |doi= 10.1074/jbc.R000028200 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on NTS... {November 9, 2007 2:12:18 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:13:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neurotensin
| HGNCid = 8038
| Symbol = NTS
| AltSymbols =; NT; NMN-125; NN; NT/N; NTS1
| OMIM = 162650
| ECnumber =
| Homologene = 4506
| MGIid = 1328351
| GeneAtlas_image1 = PBB_GE_NTS_206291_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0050880 |text = regulation of blood vessel size}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4922
| Hs_Ensembl = ENSG00000133636
| Hs_RefseqProtein = NP_006174
| Hs_RefseqmRNA = NM_006183
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 84792206
| Hs_GenLoc_end = 84800894
| Hs_Uniprot = P30990
| Mm_EntrezGene = 67405
| Mm_Ensembl = ENSMUSG00000019890
| Mm_RefseqmRNA = NM_024435
| Mm_RefseqProtein = NP_077755
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 101911446
| Mm_GenLoc_end = 101920123
| Mm_Uniprot = Q9D3P9
}}
}}
'''Neurotensin''', also known as '''NTS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.<ref>{{cite web | title = Entrez Gene: NTS neurotensin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4922| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vincent JP |title=Neurotensin receptors: binding properties, transduction pathways, and structure. |journal=Cell. Mol. Neurobiol. |volume=15 |issue= 5 |pages= 501-12 |year= 1996 |pmid= 8719037 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:16:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
| PDB = {{PDB2|1iru}}
| Name = Proteasome (prosome, macropain) subunit, beta type, 7
| HGNCid = 9544
| Symbol = PSMB7
| AltSymbols =; Z
| OMIM = 604030
| ECnumber =
| Homologene = 2093
| MGIid = 107637
| GeneAtlas_image1 = PBB_GE_PSMB7_200786_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5695
| Hs_Ensembl = ENSG00000136930
| Hs_RefseqProtein = NP_002790
| Hs_RefseqmRNA = NM_002799
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 126155566
| Hs_GenLoc_end = 126217542
| Hs_Uniprot = Q99436
| Mm_EntrezGene = 19177
| Mm_Ensembl = ENSMUSG00000026750
| Mm_RefseqmRNA = NM_011187
| Mm_RefseqProtein = NP_035317
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 38410046
| Mm_GenLoc_end = 38465927
| Mm_Uniprot = Q5D098
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 7''', also known as '''PSMB7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).<ref>{{cite web | title = Entrez Gene: PSMB7 proteasome (prosome, macropain) subunit, beta type, 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5695| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Rivett AJ, Bose S, Brooks P, Broadfoot KI |title=Regulation of proteasome complexes by gamma-interferon and phosphorylation. |journal=Biochimie |volume=83 |issue= 3-4 |pages= 363-6 |year= 2001 |pmid= 11295498 |doi= }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PSMC6... {November 9, 2007 2:16:54 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:17:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 6
| HGNCid = 9553
| Symbol = PSMC6
| AltSymbols =; CADP44; MGC12520; P44; SUG2; p42
| OMIM = 602708
| ECnumber =
| Homologene = 2099
| MGIid = 1914339
| GeneAtlas_image1 = PBB_GE_PSMC6_201699_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5706
| Hs_Ensembl = ENSG00000100519
| Hs_RefseqProtein = NP_002797
| Hs_RefseqmRNA = NM_002806
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 52243668
| Hs_GenLoc_end = 52264463
| Hs_Uniprot = P62333
| Mm_EntrezGene = 67089
| Mm_Ensembl = ENSMUSG00000021832
| Mm_RefseqmRNA = NM_025959
| Mm_RefseqProtein = NP_080235
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 44251722
| Mm_GenLoc_end = 44271565
| Mm_Uniprot = Q14AQ1
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 6''', also known as '''PSMC6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.<ref>{{cite web | title = Entrez Gene: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5706| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Hastings R, Walker G, Eyheralde I, ''et al.'' |title=Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. |journal=Mol. Biol. Rep. |volume=26 |issue= 1-2 |pages= 35-8 |year= 1999 |pmid= 10363644 |doi= }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PSMD1... {November 9, 2007 2:17:34 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:18:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
| HGNCid = 9554
| Symbol = PSMD1
| AltSymbols =; MGC133040; MGC133041; P112; S1
| OMIM =
| ECnumber =
| Homologene = 2100
| MGIid = 1917497
| GeneAtlas_image1 = PBB_GE_PSMD1_201198_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMD1_201199_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005838 |text = proteasome regulatory particle (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5707
| Hs_Ensembl = ENSG00000173692
| Hs_RefseqProtein = NP_002798
| Hs_RefseqmRNA = NM_002807
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 231629836
| Hs_GenLoc_end = 231745712
| Hs_Uniprot = Q99460
| Mm_EntrezGene = 70247
| Mm_Ensembl = ENSMUSG00000026229
| Mm_RefseqmRNA = NM_027357
| Mm_RefseqProtein = NP_081633
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 87895790
| Mm_GenLoc_end = 87970466
| Mm_Uniprot = A0JLU3
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1''', also known as '''PSMD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding.<ref>{{cite web | title = Entrez Gene: PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5707| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PSMD2... {November 9, 2007 2:18:35 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:19:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
| HGNCid = 9559
| Symbol = PSMD2
| AltSymbols =; MGC14274; P97; S2; TRAP2
| OMIM = 606223
| ECnumber =
| Homologene = 2101
| MGIid = 1096584
| GeneAtlas_image1 = PBB_GE_PSMD2_200830_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005838 |text = proteasome regulatory particle (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5708
| Hs_Ensembl = ENSG00000175166
| Hs_RefseqProtein = NP_002799
| Hs_RefseqmRNA = NM_002808
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 185499189
| Hs_GenLoc_end = 185509531
| Hs_Uniprot = Q13200
| Mm_EntrezGene = 21762
| Mm_Ensembl = ENSMUSG00000006998
| Mm_RefseqmRNA = NM_134101
| Mm_RefseqProtein = NP_598862
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 20565229
| Mm_GenLoc_end = 20576955
| Mm_Uniprot = Q3TI61
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2''', also known as '''PSMD2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.<ref>{{cite web | title = Entrez Gene: PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5708| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 9, 2007 2:02:24 PM PST} 
