AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:20:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APBB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e45.
| PDB = {{PDB2|2e45}}
| Name = Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
| HGNCid = 581
| Symbol = APBB1
| AltSymbols =; FE65; MGC:9072; RIR
| OMIM = 602709
| ECnumber =
| Homologene = 898
| MGIid = 107765
| GeneAtlas_image1 = PBB_GE_APBB1_202652_at_tn.png
| Function = {{GNF_GO|id=GO:0001540 |text = beta-amyloid binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0035035 |text = histone acetyltransferase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0030048 |text = actin filament-based movement}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045749 |text = negative regulation of S phase of mitotic cell cycle}} {{GNF_GO|id=GO:0050760 |text = negative regulation of thymidylate synthase biosynthetic process}} {{GNF_GO|id=GO:0050821 |text = protein stabilization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 322
| Hs_Ensembl = ENSG00000166313
| Hs_RefseqProtein = NP_001155
| Hs_RefseqmRNA = NM_001164
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 6372964
| Hs_GenLoc_end = 6389153
| Hs_Uniprot = O00213
| Mm_EntrezGene = 11785
| Mm_Ensembl = ENSMUSG00000037032
| Mm_RefseqmRNA = NM_009685
| Mm_RefseqProtein = NP_033815
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 105432305
| Mm_GenLoc_end = 105442536
| Mm_Uniprot = Q80Y77
}}
}}
'''Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)''', also known as '''APBB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.<ref>{{cite web | title = Entrez Gene: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=322| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Russo T, Faraonio R, Minopoli G, ''et al.'' |title=Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. |journal=FEBS Lett. |volume=434 |issue= 1-2 |pages= 1-7 |year= 1998 |pmid= 9738440 |doi= }}
*{{cite journal | author=Askanas V, Engel WK |title=Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging. |journal=Current opinion in rheumatology |volume=15 |issue= 6 |pages= 737-44 |year= 2004 |pmid= 14569203 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:44:51 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FOLH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z8l.
| PDB = {{PDB2|1z8l}}, {{PDB2|2c6c}}, {{PDB2|2c6g}}, {{PDB2|2c6p}}, {{PDB2|2cij}}, {{PDB2|2jbj}}, {{PDB2|2jbk}}, {{PDB2|2oot}}, {{PDB2|2pvv}}, {{PDB2|2pvw}}
| Name = Folate hydrolase (prostate-specific membrane antigen) 1
| HGNCid = 3788
| Symbol = FOLH1
| AltSymbols =; PSM; FGCP; FOLH; GCP2; GCPII; NAALAD1; NAALAdase; PSMA; mGCP
| OMIM = 600934
| ECnumber =
| Homologene = 71658
| MGIid =
| GeneAtlas_image1 = PBB_GE_FOLH1_205860_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_FOLH1_211303_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_FOLH1_215363_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004180 |text = carboxypeptidase activity}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016805 |text = dipeptidase activity}} {{GNF_GO|id=GO:0043275 |text = glutamate carboxypeptidase II activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2346
| Hs_Ensembl = ENSG00000086205
| Hs_RefseqProtein = NP_001014986
| Hs_RefseqmRNA = NM_001014986
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 49124766
| Hs_GenLoc_end = 49186798
| Hs_Uniprot = Q04609
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Folate hydrolase (prostate-specific membrane antigen) 1''', also known as '''FOLH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.<ref>{{cite web | title = Entrez Gene: FOLH1 folate hydrolase (prostate-specific membrane antigen) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2346| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bander NH, Nanus DM, Milowsky MI, ''et al.'' |title=Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen. |journal=Semin. Oncol. |volume=30 |issue= 5 |pages= 667-76 |year= 2003 |pmid= 14571414 |doi= }}
*{{cite journal | author=Rajasekaran AK, Anilkumar G, Christiansen JJ |title=Is prostate-specific membrane antigen a multifunctional protein? |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 5 |pages= C975-81 |year= 2005 |pmid= 15840561 |doi= 10.1152/ajpcell.00506.2004 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on GRIA1... {November 8, 2007 2:45:45 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:46:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, ionotropic, AMPA 1
| HGNCid = 4571
| Symbol = GRIA1
| AltSymbols =; GLUH1; GLUR1; GLURA; HBGR1; MGC133252
| OMIM = 138248
| ECnumber =
| Homologene = 20226
| MGIid = 95808
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004971 |text = alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015277 |text = kainate selective glutamate receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0014069 |text = postsynaptic density}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007616 |text = long-term memory}} {{GNF_GO|id=GO:0031623 |text = receptor internalization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2890
| Hs_Ensembl = ENSG00000155511
| Hs_RefseqProtein = NP_000818
| Hs_RefseqmRNA = NM_000827
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 152850499
| Hs_GenLoc_end = 153171354
| Hs_Uniprot = P42261
| Mm_EntrezGene = 14799
| Mm_Ensembl = ENSMUSG00000020524
| Mm_RefseqmRNA = NM_008165
| Mm_RefseqProtein = NP_032191
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 57017321
| Mm_GenLoc_end = 57143990
| Mm_Uniprot = Q5NBY0
}}
}}
'''Glutamate receptor, ionotropic, AMPA 1''', also known as '''GRIA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.<ref>{{cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:48:56 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GYPA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1afo.
| PDB = {{PDB2|1afo}}
| Name = Glycophorin A (MNS blood group)
| HGNCid = 4702
| Symbol = GYPA
| AltSymbols =; MN; MNS; CD235a; GPA; GPErik; GPSAT; GpMiIII; HGpMiIII; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C)
| OMIM = 111300
| ECnumber =
| Homologene = 48076
| MGIid =
| GeneAtlas_image1 = PBB_GE_GYPA_205837_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GYPA_205838_at_tn.png
| GeneAtlas_image3 = PBB_GE_GYPA_211820_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2993
| Hs_Ensembl = ENSG00000170180
| Hs_RefseqProtein = NP_002090
| Hs_RefseqmRNA = NM_002099
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 145249906
| Hs_GenLoc_end = 145281294
| Hs_Uniprot = P02724
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Glycophorin A (MNS blood group)''', also known as '''GYPA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.<ref>{{cite web | title = Entrez Gene: GYPA glycophorin A (MNS blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2993| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification. |journal=Hum. Mutat. |volume=6 |issue= 3 |pages= 199-209 |year= 1996 |pmid= 8535438 |doi= 10.1002/humu.1380060302 }}
*{{cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of glycophorin MNS variants. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=4 |issue= 4 |pages= 357-65 |year= 1997 |pmid= 9269716 |doi= }}
*{{cite journal | author=Johnson ST, McFarland JG, Kelly KJ, ''et al.'' |title=Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination. |journal=Transfusion |volume=42 |issue= 5 |pages= 567-71 |year= 2002 |pmid= 12084164 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:54:33 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MAX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1an2.
| PDB = {{PDB2|1an2}}, {{PDB2|1hlo}}, {{PDB2|1nkp}}, {{PDB2|1nlw}}, {{PDB2|1r05}}
| Name = MYC associated factor X
| HGNCid = 6913
| Symbol = MAX
| AltSymbols =; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; orf1
| OMIM = 154950
| ECnumber =
| Homologene = 1786
| MGIid = 96921
| GeneAtlas_image1 = PBB_GE_MAX_214108_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAX_208403_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAX_209331_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4149
| Hs_Ensembl = ENSG00000125952
| Hs_RefseqProtein = NP_002373
| Hs_RefseqmRNA = NM_002382
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 64542645
| Hs_GenLoc_end = 64638980
| Hs_Uniprot = P61244
| Mm_EntrezGene = 17187
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001002021
| Mm_RefseqProtein = XP_001002021
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''MYC associated factor X''', also known as '''MAX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown.<ref>{{cite web | title = Entrez Gene: MAX MYC associated factor X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4149| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Grandori C, Cowley SM, James LP, Eisenman RN |title=The Myc/Max/Mad network and the transcriptional control of cell behavior. |journal=Annu. Rev. Cell Dev. Biol. |volume=16 |issue= |pages= 653-99 |year= 2001 |pmid= 11031250 |doi= 10.1146/annurev.cellbio.16.1.653 }}
*{{cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1-14 |year= 2001 |pmid= 11602341 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:57:32 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRG2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h8u.
| PDB = {{PDB2|1h8u}}, {{PDB2|2brs}}
| Name = Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
| HGNCid = 9362
| Symbol = PRG2
| AltSymbols =; MBP; BMPG; MGC14537
| OMIM = 605601
| ECnumber =
| Homologene = 2044
| MGIid = 103294
| GeneAtlas_image1 = PBB_GE_PRG2_211743_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5553
| Hs_Ensembl = ENSG00000186652
| Hs_RefseqProtein = NP_002719
| Hs_RefseqmRNA = NM_002728
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 56910832
| Hs_GenLoc_end = 56914684
| Hs_Uniprot = P13727
| Mm_EntrezGene = 19074
| Mm_Ensembl = ENSMUSG00000027073
| Mm_RefseqmRNA = NM_008920
| Mm_RefseqProtein = NP_032946
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84781300
| Mm_GenLoc_end = 84784471
| Mm_Uniprot = Q545D8
}}
}}
'''Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)''', also known as '''PRG2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.<ref>{{cite web | title = Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5553| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vanhaesebroeck B, Alessi DR |title=The PI3K-PDK1 connection: more than just a road to PKB. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 561-76 |year= 2000 |pmid= 10698680 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:58:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKCH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fk9.
| PDB = {{PDB2|2fk9}}
| Name = Protein kinase C, eta
| HGNCid = 9403
| Symbol = PRKCH
| AltSymbols =; MGC26269; MGC5363; PKC-L; PKCL; PRKCL; nPKC-eta
| OMIM = 605437
| ECnumber =
| Homologene = 84384
| MGIid = 97600
| GeneAtlas_image1 = PBB_GE_PRKCH_206099_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKCH_218764_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004697 |text = protein kinase C activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5583
| Hs_Ensembl = ENSG00000027075
| Hs_RefseqProtein = NP_006246
| Hs_RefseqmRNA = NM_006255
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 60858186
| Hs_GenLoc_end = 61087443
| Hs_Uniprot = P24723
| Mm_EntrezGene = 18755
| Mm_Ensembl = ENSMUSG00000021108
| Mm_RefseqmRNA = NM_008856
| Mm_RefseqProtein = NP_032882
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 74503879
| Mm_GenLoc_end = 74697023
| Mm_Uniprot = Q3U1I0
}}
}}
'''Protein kinase C, eta''', also known as '''PRKCH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.<ref>{{cite web | title = Entrez Gene: PRKCH protein kinase C, eta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5583| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 8, 2007 1:19:15 PM PST} 
{November 8, 2007 2:37:18 PM PST} 
