INFO: Beginning work on COL4A4... {November 8, 2007 1:04:19 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:04:51 AM PST}
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 4
| HGNCid = 2206
| Symbol = COL4A4
| AltSymbols =; CA44
| OMIM = 120131
| ECnumber =
| Homologene = 20071
| MGIid = 104687
| GeneAtlas_image1 = PBB_GE_COL4A4_214602_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0042062 |text = long-term strengthening of neuromuscular junction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1286
| Hs_Ensembl = ENSG00000081052
| Hs_RefseqProtein = NP_000083
| Hs_RefseqmRNA = NM_000092
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 227578177
| Hs_GenLoc_end = 227737519
| Hs_Uniprot = P53420
| Mm_EntrezGene = 12829
| Mm_Ensembl = ENSMUSG00000067158
| Mm_RefseqmRNA = NM_007735
| Mm_RefseqProtein = NP_031761
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 82331582
| Mm_GenLoc_end = 82465816
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 4''', also known as '''COL4A4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.<ref>{{cite web | title = Entrez Gene: COL4A4 collagen, type IV, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1286| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Hudson BG, Reeders ST, Tryggvason K |title=Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26033-6 |year= 1994 |pmid= 8253711 |doi= }}
*{{cite journal | author=Lemmink HH, Schröder CH, Monnens LA, Smeets HJ |title=The clinical spectrum of type IV collagen mutations. |journal=Hum. Mutat. |volume=9 |issue= 6 |pages= 477-99 |year= 1997 |pmid= 9195222 |doi= 10.1002/(SICI)1098-1004(1997)9:6<477::AID-HUMU1>3.0.CO;2-# }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Pescucci C, Longo I, Bruttini M, ''et al.'' |title=Type-IV collagen related diseases. |journal=J. Nephrol. |volume=16 |issue= 2 |pages= 314-6 |year= 2003 |pmid= 12768082 |doi= }}
*{{cite journal | author=Torra R, Tazón-Vega B, Ars E, Ballarín J |title=Collagen type IV (alpha3-alpha4) nephropathy: from isolated haematuria to renal failure. |journal=Nephrol. Dial. Transplant. |volume=19 |issue= 10 |pages= 2429-32 |year= 2005 |pmid= 15280517 |doi= 10.1093/ndt/gfh435 }}
*{{cite journal | author=Rana K, Wang YY, Buzza M, ''et al.'' |title=The genetics of thin basement membrane nephropathy. |journal=Semin. Nephrol. |volume=25 |issue= 3 |pages= 163-70 |year= 2005 |pmid= 15880327 |doi= }}
*{{cite journal | author=Maziers N, Dahan K, Pirson Y |title=[From Alport syndrome to benign familial hematuria: clinical and genetic aspect] |journal=Nephrol. Ther. |volume=1 |issue= 2 |pages= 90-100 |year= 2006 |pmid= 16895672 |doi= 10.1016/j.nephro.2005.03.005 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:09:35 AM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HNRPD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hd0.
| PDB = {{PDB2|1hd0}}, {{PDB2|1hd1}}, {{PDB2|1iqt}}, {{PDB2|1wtb}}, {{PDB2|1x0f}}
| Name = Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
| HGNCid = 5036
| Symbol = HNRPD
| AltSymbols =; AUF1; AUF1A; P37; hnRNPD0
| OMIM = 601324
| ECnumber =
| Homologene = 22410
| MGIid =
| GeneAtlas_image1 = PBB_GE_HNRPD_209330_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPD_221480_at_tn.png
| GeneAtlas_image3 = PBB_GE_HNRPD_221481_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0006402 |text = mRNA catabolic process}} {{GNF_GO|id=GO:0043488 |text = regulation of mRNA stability}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3184
| Hs_Ensembl = ENSG00000138668
| Hs_RefseqProtein = NP_001003810
| Hs_RefseqmRNA = NM_001003810
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 83493491
| Hs_GenLoc_end = 83514173
| Hs_Uniprot = Q14103
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)''', also known as '''HNRPD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.<ref>{{cite web | title = Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3184| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:12:03 AM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_INSL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h8b.
| PDB = {{PDB2|2h8b}}
| Name = Insulin-like 3 (Leydig cell)
| HGNCid = 6086
| Symbol = INSL3
| AltSymbols =; MGC119818; MGC119819; RLF; RLNL
| OMIM = 146738
| ECnumber =
| Homologene = 4048
| MGIid = 108427
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005158 |text = insulin receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3640
| Hs_Ensembl =
| Hs_RefseqProtein = NP_005534
| Hs_RefseqmRNA = NM_005543
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16336
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_013564
| Mm_RefseqProtein = NP_038592
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Insulin-like 3 (Leydig cell)''', also known as '''INSL3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.<ref>{{cite web | title = Entrez Gene: INSL3 insulin-like 3 (Leydig cell)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3640| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on NCSTN... {November 8, 2007 1:24:14 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:24:47 AM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nicastrin
| HGNCid = 17091
| Symbol = NCSTN
| AltSymbols =; APH2; KIAA0253; RP11-517F10.1
| OMIM = 605254
| ECnumber =
| Homologene = 41029
| MGIid = 1891700
| GeneAtlas_image1 = PBB_GE_NCSTN_208759_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006509 |text = membrane protein ectodomain proteolysis}} {{GNF_GO|id=GO:0007220 |text = Notch receptor processing}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0042987 |text = amyloid precursor protein catabolic process}} {{GNF_GO|id=GO:0043085 |text = positive regulation of enzyme activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23385
| Hs_Ensembl = ENSG00000162736
| Hs_RefseqProtein = NP_056146
| Hs_RefseqmRNA = NM_015331
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 158579678
| Hs_GenLoc_end = 158595366
| Hs_Uniprot = Q92542
| Mm_EntrezGene = 59287
| Mm_Ensembl = ENSMUSG00000003458
| Mm_RefseqmRNA = NM_021607
| Mm_RefseqProtein = NP_067620
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173902696
| Mm_GenLoc_end = 173919424
| Mm_Uniprot = Q3T9E5
}}
}}
'''Nicastrin''', also known as '''NCSTN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: NCSTN nicastrin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23385| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PSMC2... {November 8, 2007 1:17:16 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:18:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 2
| HGNCid = 9548
| Symbol = PSMC2
| AltSymbols =; S7; MGC3004; MSS1; Nbla10058
| OMIM = 154365
| ECnumber =
| Homologene = 2096
| MGIid = 109555
| GeneAtlas_image1 = PBB_GE_PSMC2_201068_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMC2_201067_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5701
| Hs_Ensembl = ENSG00000161057
| Hs_RefseqProtein = NP_002794
| Hs_RefseqmRNA = NM_002803
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 102775325
| Hs_GenLoc_end = 102795891
| Hs_Uniprot = P35998
| Mm_EntrezGene = 19181
| Mm_Ensembl = ENSMUSG00000028932
| Mm_RefseqmRNA = NM_011188
| Mm_RefseqProtein = NP_035318
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 21297107
| Mm_GenLoc_end = 21315608
| Mm_Uniprot = Q3U5V3
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 2''', also known as '''PSMC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.<ref>{{cite web | title = Entrez Gene: PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5701| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PTPN12... {November 8, 2007 1:18:55 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:19:46 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein tyrosine phosphatase, non-receptor type 12
| HGNCid = 9645
| Symbol = PTPN12
| AltSymbols =; PTP-PEST; PTPG1
| OMIM = 600079
| ECnumber =
| Homologene = 37691
| MGIid = 104673
| GeneAtlas_image1 = PBB_GE_PTPN12_202006_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTPN12_216915_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004726 |text = non-membrane spanning protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5782
| Hs_Ensembl = ENSG00000127947
| Hs_RefseqProtein = NP_002826
| Hs_RefseqmRNA = NM_002835
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 77004351
| Hs_GenLoc_end = 77107324
| Hs_Uniprot = Q05209
| Mm_EntrezGene = 19248
| Mm_Ensembl = ENSMUSG00000028771
| Mm_RefseqmRNA = NM_011203
| Mm_RefseqProtein = NP_035333
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 20498465
| Mm_GenLoc_end = 20567621
| Mm_Uniprot = Q3TVC3
}}
}}
'''Protein tyrosine phosphatase, non-receptor type 12''', also known as '''PTPN12''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.<ref>{{cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non-receptor type 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5782| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}