INFO: Beginning work on AGTR2... {November 7, 2007 3:55:29 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:56:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Angiotensin II receptor, type 2
| HGNCid = 338
| Symbol = AGTR2
| AltSymbols =; AT2; ATGR2; MRX88
| OMIM = 300034
| ECnumber =
| Homologene = 20172
| MGIid = 87966
| GeneAtlas_image1 = PBB_GE_AGTR2_207294_at_tn.png
| GeneAtlas_image2 = PBB_GE_AGTR2_207293_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_AGTR2_222321_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}} {{GNF_GO|id=GO:0004947 |text = bradykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0002033 |text = angiotensin mediated vasodilation during regulation of blood pressure}} {{GNF_GO|id=GO:0002035 |text = brain renin-angiotensin system}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 186
| Hs_Ensembl = ENSG00000180772
| Hs_RefseqProtein = NP_000677
| Hs_RefseqmRNA = NM_000686
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 115216003
| Hs_GenLoc_end = 115220253
| Hs_Uniprot = P50052
| Mm_EntrezGene = 11609
| Mm_Ensembl = ENSMUSG00000068122
| Mm_RefseqmRNA = NM_007429
| Mm_RefseqProtein = NP_031455
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 20641585
| Mm_GenLoc_end = 20646123
| Mm_Uniprot = Q3US12
}}
}}
'''Angiotensin II receptor, type 2''', also known as '''AGTR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an intergral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.<ref>{{cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Regitz-Zagrosek V, Neuss M, Warnecke C, ''et al.'' |title=Subtype 2 and atypical angiotensin receptors in the human heart. |journal=Basic Res. Cardiol. |volume=91 Suppl 2 |issue= |pages= 73-7 |year= 1997 |pmid= 8957548 |doi= }}
*{{cite journal | author=Berry C, Touyz R, Dominiczak AF, ''et al.'' |title=Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 6 |pages= H2337-65 |year= 2002 |pmid= 11709400 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:03:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BGN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ft3.
| PDB = {{PDB2|2ft3}}
| Name = Biglycan
| HGNCid = 1044
| Symbol = BGN
| AltSymbols =; DSPG1; PG-S1; PGI; SLRR1A
| OMIM = 301870
| ECnumber =
| Homologene = 1293
| MGIid = 88158
| GeneAtlas_image1 = PBB_GE_BGN_201262_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BGN_201261_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_BGN_213905_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0030133 |text = transport vesicle}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 633
| Hs_Ensembl = ENSG00000182492
| Hs_RefseqProtein = NP_001702
| Hs_RefseqmRNA = NM_001711
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152413591
| Hs_GenLoc_end = 152428206
| Hs_Uniprot = P21810
| Mm_EntrezGene = 12111
| Mm_Ensembl = ENSMUSG00000031375
| Mm_RefseqmRNA = NM_007542
| Mm_RefseqProtein = NP_031568
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 69736364
| Mm_GenLoc_end = 69748653
| Mm_Uniprot = Q3TAF9
}}
}}
'''Biglycan''', also known as '''BGN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome.<ref>{{cite web | title = Entrez Gene: BGN biglycan| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=633| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Iozzo RV |title=The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18843-6 |year= 1999 |pmid= 10383378 |doi= }}
*{{cite journal | author=Klezovitch O, Scanu AM |title=Domains of apolipoprotein E involved in the binding to the protein core of biglycan of the vascular extracellular matrix: potential relationship between retention and anti-atherogenic properties of this apolipoprotein. |journal=Trends Cardiovasc. Med. |volume=11 |issue= 7 |pages= 263-8 |year= 2001 |pmid= 11709279 |doi= }}
*{{cite journal | author=Fujisawa R |title=[Recent advances in research on bone matrix proteins] |journal=Nippon Rinsho |volume=60 Suppl 3 |issue= |pages= 72-8 |year= 2002 |pmid= 11979972 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on GRN... {November 7, 2007 4:07:52 PM PST}
UPLOAD: Added new Image to wiki: {November 7, 2007 4:09:01 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:09:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g26.
| PDB = {{PDB2|1g26}}
| Name = Granulin
| HGNCid = 4601
| Symbol = GRN
| AltSymbols =; GEP; GP88; PCDGF; PEPI; PGRN
| OMIM = 138945
| ECnumber =
| Homologene = 1577
| MGIid = 95832
| GeneAtlas_image1 = PBB_GE_GRN_211284_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRN_200678_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_GRN_216041_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0001835 |text = blastocyst hatching}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2896
| Hs_Ensembl = ENSG00000030582
| Hs_RefseqProtein = NP_001012497
| Hs_RefseqmRNA = NM_001012479
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39778017
| Hs_GenLoc_end = 39785996
| Hs_Uniprot = P28799
| Mm_EntrezGene = 14824
| Mm_Ensembl = ENSMUSG00000034708
| Mm_RefseqmRNA = XM_984981
| Mm_RefseqProtein = XP_990075
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102246571
| Mm_GenLoc_end = 102252895
| Mm_Uniprot = Q3TVQ3
}}
}}
'''Granulin''', also known as '''GRN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.<ref>{{cite web | title = Entrez Gene: GRN granulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2896| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Serrero G |title=Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 3 |pages= 409-13 |year= 2003 |pmid= 12914763 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:15:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qm9.
| PDB = {{PDB2|1qm9}}, {{PDB2|1sjq}}, {{PDB2|1sjr}}, {{PDB2|2ad9}}, {{PDB2|2adb}}, {{PDB2|2adc}}, {{PDB2|2evz}}
| Name = Polypyrimidine tract binding protein 1
| HGNCid = 9583
| Symbol = PTBP1
| AltSymbols =; HNRNPI; HNRPI; MGC10830; MGC8461; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; pPTB
| OMIM = 600693
| ECnumber =
| Homologene = 49188
| MGIid = 97791
| GeneAtlas_image1 = PBB_GE_PTBP1_212016_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTBP1_202189_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTBP1_211270_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008187 |text = poly-pyrimidine tract binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5725
| Hs_Ensembl = ENSG00000011304
| Hs_RefseqProtein = NP_002810
| Hs_RefseqmRNA = NM_002819
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 748411
| Hs_GenLoc_end = 763327
| Hs_Uniprot = P26599
| Mm_EntrezGene = 19205
| Mm_Ensembl = ENSMUSG00000006498
| Mm_RefseqmRNA = NM_001077363
| Mm_RefseqProtein = NP_001070831
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 79257797
| Mm_GenLoc_end = 79267561
| Mm_Uniprot = Q8C2R5
}}
}}
'''Polypyrimidine tract binding protein 1''', also known as '''PTBP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5725| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 4:09:01 PM PST} 
