INFO: Beginning work on AFP... {November 7, 2007 1:10:32 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:11:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alpha-fetoprotein
| HGNCid = 317
| Symbol = AFP
| AltSymbols =; FETA; HPAFP
| OMIM = 104150
| ECnumber =
| Homologene = 36278
| MGIid = 87951
| GeneAtlas_image1 = PBB_GE_AFP_204694_at_tn.png
| Function = {{GNF_GO|id=GO:0005386 |text = transmembrane transporter activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016151 |text = nickel ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001542 |text = ovulation (sensu Mammalia)}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}} {{GNF_GO|id=GO:0042448 |text = progesterone metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 174
| Hs_Ensembl = ENSG00000081051
| Hs_RefseqProtein = NP_001125
| Hs_RefseqmRNA = NM_001134
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 74520797
| Hs_GenLoc_end = 74540356
| Hs_Uniprot = P02771
| Mm_EntrezGene = 11576
| Mm_Ensembl = ENSMUSG00000054932
| Mm_RefseqmRNA = NM_007423
| Mm_RefseqProtein = NP_031449
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 91565937
| Mm_GenLoc_end = 91584107
| Mm_Uniprot = Q3TGA3
}}
}}
'''Alpha-fetoprotein''', also known as '''AFP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.<ref>{{cite web | title = Entrez Gene: AFP alpha-fetoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=174| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nahon JL |title=The regulation of albumin and alpha-fetoprotein gene expression in mammals. |journal=Biochimie |volume=69 |issue= 5 |pages= 445-59 |year= 1987 |pmid= 2445387 |doi= }}
*{{cite journal | author=Tilghman SM |title=The structure and regulation of the alpha-fetoprotein and albumin genes. |journal=Oxf. Surv. Eukaryot. Genes |volume=2 |issue= |pages= 160-206 |year= 1989 |pmid= 2474300 |doi= }}
*{{cite journal | author=Mizejewski GJ |title=Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy. |journal=Expert Rev Anticancer Ther |volume=2 |issue= 6 |pages= 709-35 |year= 2003 |pmid= 12503217 |doi= 10.1586/14737140.2.6.709 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CD63... {November 7, 2007 1:11:59 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:12:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD63 molecule
| HGNCid = 1692
| Symbol = CD63
| AltSymbols =; LAMP-3; ME491; MLA1; OMA81H; TSPAN30
| OMIM = 155740
| ECnumber =
| Homologene = 37526
| MGIid =
| GeneAtlas_image1 = PBB_GE_CD63_200663_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005765 |text = lysosomal membrane}} {{GNF_GO|id=GO:0005770 |text = late endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 967
| Hs_Ensembl = ENSG00000135404
| Hs_RefseqProtein = NP_001035123
| Hs_RefseqmRNA = NM_001040034
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 54405533
| Hs_GenLoc_end = 54409711
| Hs_Uniprot = P08962
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD63 molecule''', also known as '''CD63''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.<ref>{{cite web | title = Entrez Gene: CD63 CD63 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=967| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1-4 |year= 1991 |pmid= 1879540 |doi= }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CRH... {November 7, 2007 1:15:02 PM PST}
UPLOAD: Added new Image to wiki: {November 7, 2007 1:15:59 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:16:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CRH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1go9.
| PDB = {{PDB2|1go9}}, {{PDB2|1goe}}
| Name = Corticotropin releasing hormone
| HGNCid = 2355
| Symbol = CRH
| AltSymbols =; CRF
| OMIM = 122560
| ECnumber =
| Homologene = 599
| MGIid = 88496
| GeneAtlas_image1 = PBB_GE_CRH_205630_at_tn.png
| GeneAtlas_image2 = PBB_GE_CRH_205629_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007567 |text = parturition}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1392
| Hs_Ensembl = ENSG00000147571
| Hs_RefseqProtein = NP_000747
| Hs_RefseqmRNA = NM_000756
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 67251166
| Hs_GenLoc_end = 67253380
| Hs_Uniprot = P06850
| Mm_EntrezGene = 12918
| Mm_Ensembl = ENSMUSG00000049796
| Mm_RefseqmRNA = NM_205769
| Mm_RefseqProtein = NP_991338
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 19885565
| Mm_GenLoc_end = 19887480
| Mm_Uniprot = Q14AA2
}}
}}
'''Corticotropin releasing hormone''', also known as '''CRH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.<ref>{{cite web | title = Entrez Gene: CRH corticotropin releasing hormone| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1392| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Florio P, Severi FM, Ciarmela P, ''et al.'' |title=Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family. |journal=Endocrine |volume=19 |issue= 1 |pages= 91-102 |year= 2003 |pmid= 12583606 |doi= }}
*{{cite journal | author=Florio P, Rossi M, Sigurdardottir M, ''et al.'' |title=Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A. |journal=Steroids |volume=68 |issue= 10-13 |pages= 801-7 |year= 2004 |pmid= 14667971 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:18:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FEN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ul1.
| PDB = {{PDB2|1ul1}}
| Name = Flap structure-specific endonuclease 1
| HGNCid = 3650
| Symbol = FEN1
| AltSymbols =; FEN-1; MF1; RAD2
| OMIM = 600393
| ECnumber =
| Homologene = 3034
| MGIid = 102779
| GeneAtlas_image1 = PBB_GE_FEN1_204767_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FEN1_204768_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004523 |text = ribonuclease H activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008309 |text = double-stranded DNA specific exodeoxyribonuclease activity}} {{GNF_GO|id=GO:0008409 |text = 5'-3' exonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017108 |text = 5'-flap endonuclease activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0009650 |text = UV protection}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2237
| Hs_Ensembl = ENSG00000168496
| Hs_RefseqProtein = NP_004102
| Hs_RefseqmRNA = NM_004111
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 61316726
| Hs_GenLoc_end = 61321284
| Hs_Uniprot = P39748
| Mm_EntrezGene = 14156
| Mm_Ensembl = ENSMUSG00000024742
| Mm_RefseqmRNA = NM_007999
| Mm_RefseqProtein = NP_032025
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 10266184
| Mm_GenLoc_end = 10270988
| Mm_Uniprot = Q3TGH6
}}
}}
'''Flap structure-specific endonuclease 1''', also known as '''FEN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.<ref>{{cite web | title = Entrez Gene: FEN1 flap structure-specific endonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2237| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:19:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FTL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ffx.
| PDB = {{PDB2|2ffx}}, {{PDB2|2fg4}}, {{PDB2|2fg8}}
| Name = Ferritin, light polypeptide
| HGNCid = 3999
| Symbol = FTL
| AltSymbols =; MGC71996
| OMIM = 134790
| ECnumber =
| Homologene = 79330
| MGIid = 95590
| GeneAtlas_image1 = PBB_GE_FTL_212788_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_FTL_213187_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0008199 |text = ferric iron binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008043 |text = ferritin complex}}
| Process = {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2512
| Hs_Ensembl = ENSG00000087086
| Hs_RefseqProtein = NP_000137
| Hs_RefseqmRNA = NM_000146
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 54160378
| Hs_GenLoc_end = 54161850
| Hs_Uniprot = P02792
| Mm_EntrezGene = 14337
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008049
| Mm_RefseqProtein = NP_032075
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ferritin, light polypeptide''', also known as '''FTL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.<ref>{{cite web | title = Entrez Gene: FTL ferritin, light polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2512| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Munro HN, Aziz N, Leibold EA, ''et al.'' |title=The ferritin genes: structure, expression, and regulation. |journal=Ann. N. Y. Acad. Sci. |volume=526 |issue= |pages= 113-23 |year= 1988 |pmid= 3291676 |doi= }}
*{{cite journal | author=Cazzola M, Skoda RC |title=Translational pathophysiology: a novel molecular mechanism of human disease. |journal=Blood |volume=95 |issue= 11 |pages= 3280-8 |year= 2000 |pmid= 10828006 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on LCP2... {November 7, 2007 1:20:08 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:21:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
| HGNCid = 6529
| Symbol = LCP2
| AltSymbols =; SLP-76; SLP76
| OMIM = 601603
| ECnumber =
| Homologene = 4065
| MGIid = 1321402
| GeneAtlas_image1 = PBB_GE_LCP2_205269_at_tn.png
| GeneAtlas_image2 = PBB_GE_LCP2_205270_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0045576 |text = mast cell activation}} {{GNF_GO|id=GO:0050663 |text = cytokine secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3937
| Hs_Ensembl = ENSG00000043462
| Hs_RefseqProtein = NP_005556
| Hs_RefseqmRNA = NM_005565
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 169607667
| Hs_GenLoc_end = 169657400
| Hs_Uniprot = Q13094
| Mm_EntrezGene = 16822
| Mm_Ensembl = ENSMUSG00000002699
| Mm_RefseqmRNA = NM_010696
| Mm_RefseqProtein = NP_034826
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 33947144
| Mm_GenLoc_end = 33992281
| Mm_Uniprot = Q3U5Y3
}}
}}
'''Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)''', also known as '''LCP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.<ref>{{cite web | title = Entrez Gene: LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3937| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 1:21:28 PM PST} 
{November 7, 2007 1:15:59 PM PST} 
{November 7, 2007 1:32:14 PM PST} 
{November 7, 2007 1:26:37 PM PST} 
{November 7, 2007 1:28:27 PM PST} 
