INFO: Beginning work on CACNA1A... {November 6, 2007 9:29:23 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:30:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
| HGNCid = 1388
| Symbol = CACNA1A
| AltSymbols =; APCA; CACNL1A4; CAV2.1; EA2; FHM; HPCA; MHP; MHP1; SCA6
| OMIM = 601011
| ECnumber =
| Homologene = 56383
| MGIid = 109482
| GeneAtlas_image1 = PBB_GE_CACNA1A_214933_at_tn.png
| GeneAtlas_image2 = PBB_GE_CACNA1A_206399_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CACNA1A_210770_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005245 |text = voltage-gated calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019905 |text = syntaxin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042995 |text = cell projection}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 773
| Hs_Ensembl = ENSG00000141837
| Hs_RefseqProtein = NP_000059
| Hs_RefseqmRNA = NM_000068
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 13179088
| Hs_GenLoc_end = 13478038
| Hs_Uniprot = O00555
| Mm_EntrezGene = 12286
| Mm_Ensembl = ENSMUSG00000034656
| Mm_RefseqmRNA = XM_986985
| Mm_RefseqProtein = XP_992079
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 87305750
| Mm_GenLoc_end = 87530351
| Mm_Uniprot = Q2TPN3
}}
}}
'''Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit''', also known as '''CACNA1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants have been described, however, the full-length nature of not all is known. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.<ref>{{cite web | title = Entrez Gene: CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=773| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Terwindt G, Kors E, Haan J, ''et al.'' |title=Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. |journal=Arch. Neurol. |volume=59 |issue= 6 |pages= 1016-8 |year= 2002 |pmid= 12056940 |doi= }}
*{{cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411-25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on GNB3... {November 6, 2007 9:35:32 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:36:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Guanine nucleotide binding protein (G protein), beta polypeptide 3
| HGNCid = 4400
| Symbol = GNB3
| AltSymbols =;
| OMIM = 139130
| ECnumber =
| Homologene = 55628
| MGIid = 95785
| GeneAtlas_image1 = PBB_GE_GNB3_206047_at_tn.png
| Function = {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2784
| Hs_Ensembl = ENSG00000111664
| Hs_RefseqProtein = NP_002066
| Hs_RefseqmRNA = NM_002075
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 6820713
| Hs_GenLoc_end = 6826819
| Hs_Uniprot = P16520
| Mm_EntrezGene = 14695
| Mm_Ensembl = ENSMUSG00000023439
| Mm_RefseqmRNA = NM_013530
| Mm_RefseqProtein = NP_038558
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 124799859
| Mm_GenLoc_end = 124805894
| Mm_Uniprot = Q54AE3
}}
}}
'''Guanine nucleotide binding protein (G protein), beta polypeptide 3''', also known as '''GNB3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.<ref>{{cite web | title = Entrez Gene: GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2784| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wedegaertner PB, Wilson PT, Bourne HR |title=Lipid modifications of trimeric G proteins. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 503-6 |year= 1995 |pmid= 7822269 |doi= }}
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544-52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
*{{cite journal | author=Sartori M, Parotto E, Ceolotto G, ''et al.'' |title=[C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk] |journal=Ann. Ital. Med. Int. |volume=19 |issue= 4 |pages= 240-8 |year= 2005 |pmid= 15678704 |doi= }}
*{{cite journal | author=Zhu H, Wang X, Lu Y, ''et al.'' |title=Update on G-protein polymorphisms in hypertension. |journal=Curr. Hypertens. Rep. |volume=8 |issue= 1 |pages= 23-9 |year= 2006 |pmid= 16600156 |doi= }}
*{{cite journal | author=Weder AB |title=Genetics and hypertension. |journal=Journal of clinical hypertension (Greenwich, Conn.) |volume=9 |issue= 3 |pages= 217-23 |year= 2007 |pmid= 17341998 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:44:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKCQ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xjd.
| PDB = {{PDB2|1xjd}}
| Name = Protein kinase C, theta
| HGNCid = 9410
| Symbol = PRKCQ
| AltSymbols =; MGC126514; MGC141919; PRKCT; nPKC-theta
| OMIM = 600448
| ECnumber =
| Homologene = 21263
| MGIid = 97601
| GeneAtlas_image1 = PBB_GE_PRKCQ_210039_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKCQ_210038_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004697 |text = protein kinase C activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}}
| Component = {{GNF_GO|id=GO:0001772 |text = immunological synapse}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0045086 |text = positive regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5588
| Hs_Ensembl = ENSG00000065675
| Hs_RefseqProtein = NP_006248
| Hs_RefseqmRNA = NM_006257
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 6509111
| Hs_GenLoc_end = 6662269
| Hs_Uniprot = Q04759
| Mm_EntrezGene = 18761
| Mm_Ensembl = ENSMUSG00000026778
| Mm_RefseqmRNA = NM_008859
| Mm_RefseqProtein = NP_032885
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 11090235
| Mm_GenLoc_end = 11219079
| Mm_Uniprot = Q3UK53
}}
}}
'''Protein kinase C, theta''', also known as '''PRKCQ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.<ref>{{cite web | title = Entrez Gene: PRKCQ protein kinase C, theta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5588| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Meller N, Altman A, Isakov N |title=New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. |journal=Stem Cells |volume=16 |issue= 3 |pages= 178-92 |year= 1998 |pmid= 9617893 |doi= }}
*{{cite journal | author=Greenway AL, Holloway G, McPhee DA, ''et al.'' |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 12734410 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:41:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SMAD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1khu.
| PDB = {{PDB2|1khu}}
| Name = SMAD family member 1
| HGNCid = 6767
| Symbol = SMAD1
| AltSymbols =; BSP1; JV4-1; JV41; MADH1; MADR1
| OMIM = 601595
| ECnumber =
| Homologene = 21196
| MGIid = 109452
| GeneAtlas_image1 = PBB_GE_SMAD1_210993_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007276 |text = gamete generation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009880 |text = embryonic pattern specification}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0030901 |text = midbrain development}} {{GNF_GO|id=GO:0030902 |text = hindbrain development}} {{GNF_GO|id=GO:0042592 |text = homeostatic process}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4086
| Hs_Ensembl = ENSG00000170365
| Hs_RefseqProtein = NP_001003688
| Hs_RefseqmRNA = NM_001003688
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 146622401
| Hs_GenLoc_end = 146699773
| Hs_Uniprot = Q15797
| Mm_EntrezGene = 17125
| Mm_Ensembl = ENSMUSG00000031681
| Mm_RefseqmRNA = NM_008539
| Mm_RefseqProtein = NP_032565
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 82234467
| Mm_GenLoc_end = 82295540
| Mm_Uniprot = Q6GT95
}}
}}
'''SMAD family member 1''', also known as '''SMAD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.<ref>{{cite web | title = Entrez Gene: SMAD1 SMAD family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4086| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heldin CH, Miyazono K, ten Dijke P |title=TGF-beta signalling from cell membrane to nucleus through SMAD proteins. |journal=Nature |volume=390 |issue= 6659 |pages= 465-71 |year= 1997 |pmid= 9393997 |doi= 10.1038/37284 }}
*{{cite journal | author=Massagué J |title=TGF-beta signal transduction. |journal=Annu. Rev. Biochem. |volume=67 |issue= |pages= 753-91 |year= 1998 |pmid= 9759503 |doi= 10.1146/annurev.biochem.67.1.753 }}
*{{cite journal | author=Verschueren K, Huylebroeck D |title=Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 187-99 |year= 2000 |pmid= 10647776 |doi= }}
*{{cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5-13 |year= 2000 |pmid= 10708948 |doi= }}
*{{cite journal | author=Miyazono K |title=TGF-beta signaling by Smad proteins. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 15-22 |year= 2000 |pmid= 10708949 |doi= }}
*{{cite journal | author=Attisano L, Silvestri C, Izzi L, Labbé E |title=The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling. |journal=Mol. Cell. Endocrinol. |volume=180 |issue= 1-2 |pages= 3-11 |year= 2001 |pmid= 11451566 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:50:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TRAF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1flk.
| PDB = {{PDB2|1flk}}, {{PDB2|1fll}}, {{PDB2|1kzz}}, {{PDB2|1l0a}}, {{PDB2|1rf3}}, {{PDB2|1zms}}, {{PDB2|2gkw}}
| Name = TNF receptor-associated factor 3
| HGNCid = 12033
| Symbol = TRAF3
| AltSymbols =; LAP1; CAP-1; CD40bp; CRAF1
| OMIM = 601896
| ECnumber =
| Homologene = 7981
| MGIid = 108041
| GeneAtlas_image1 = PBB_GE_TRAF3_208315_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7187
| Hs_Ensembl = ENSG00000131323
| Hs_RefseqProtein = NP_003291
| Hs_RefseqmRNA = NM_003300
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 102406268
| Hs_GenLoc_end = 102441895
| Hs_Uniprot = Q13114
| Mm_EntrezGene = 22031
| Mm_Ensembl = ENSMUSG00000021277
| Mm_RefseqmRNA = NM_001048206
| Mm_RefseqProtein = NP_001041671
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 111614356
| Mm_GenLoc_end = 111714956
| Mm_Uniprot = Q60803
}}
}}
'''TNF receptor-associated factor 3''', also known as '''TRAF3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TRAF3 TNF receptor-associated factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7187| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389-400 |year= 2001 |pmid= 11384837 |doi= }}
*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482-91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
*{{cite journal | author=Saha SK, Cheng G |title=TRAF3: a new regulator of type I interferons. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 804-7 |year= 2006 |pmid= 16582590 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 6, 2007 9:48:03 PM PST} 
{November 6, 2007 9:51:00 PM PST} 
