INFO : Beginning work on ATR... {November 1, 2007 5:07:06 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:07:33 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ataxia telangiectasia and Rad3 related
| HGNCid = 882
| Symbol = ATR
| AltSymbols =; FRP1; MEC1; SCKL; SCKL1
| OMIM = 601215
| ECnumber =
| Homologene = 68167
| MGIid =
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016773 |text = phosphotransferase activity, alcohol group as acceptor}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0032405 |text = MutLalpha complex binding}} {{GNF_GO|id=GO:0032407 |text = MutSalpha complex binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 545
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001131387
| Hs_RefseqmRNA = XM_001131387
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ataxia telangiectasia and Rad3 related''', also known as '''ATR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.<ref>{{cite web | title = Entrez Gene: ATR ataxia telangiectasia and Rad3 related| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=545| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Giaccia AJ, Kastan MB |title=The complexity of p53 modulation: emerging patterns from divergent signals. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2973-83 |year= 1998 |pmid= 9765199 |doi= }}
*{{cite journal | author=Shiloh Y |title=ATM and ATR: networking cellular responses to DNA damage. |journal=Curr. Opin. Genet. Dev. |volume=11 |issue= 1 |pages= 71-7 |year= 2001 |pmid= 11163154 |doi= }}
*{{cite journal | author=Kastan MB, Lim DS |title=The many substrates and functions of ATM. |journal=Nat. Rev. Mol. Cell Biol. |volume=1 |issue= 3 |pages= 179-86 |year= 2001 |pmid= 11252893 |doi= 10.1038/35043058 }}
*{{cite journal | author=Abraham RT |title=The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 919-25 |year= 2005 |pmid= 15279777 |doi= 10.1016/j.dnarep.2004.04.003 }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on C3... {November 1, 2007 5:07:33 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein C3 image.jpg {November 1, 2007 5:07:48 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:08:00 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c3d.
| PDB = {{PDB2|1c3d}}, {{PDB2|1ghq}}, {{PDB2|1w2s}}, {{PDB2|2a73}}, {{PDB2|2a74}}, {{PDB2|2gox}}, {{PDB2|2hr0}}, {{PDB2|2i07}}, {{PDB2|2ice}}, {{PDB2|2icf}}
| Name = Complement component 3
| HGNCid = 1318
| Symbol = C3
| AltSymbols =; ASP; CPAMD1
| OMIM = 120700
| ECnumber =
| Homologene = 68031
| MGIid = 88227
| Function = {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006957 |text = complement activation, alternative pathway}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 718
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000055
| Hs_RefseqmRNA = NM_000064
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12266
| Mm_Ensembl = ENSMUSG00000024164
| Mm_RefseqmRNA = NM_009778
| Mm_RefseqProtein = NP_033908
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 56889309
| Mm_GenLoc_end = 56913426
| Mm_Uniprot = Q207D2
}}
}}
'''Complement component 3''', also known as '''C3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection.<ref>{{cite web | title = Entrez Gene: C3 complement component 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=718| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Matsuyama W, Nakagawa M, Takashima H, ''et al.'' |title=Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters. |journal=Intern. Med. |volume=40 |issue= 12 |pages= 1254-8 |year= 2002 |pmid= 11813855 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CASP9... {November 1, 2007 5:08:00 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein CASP9 image.jpg {November 1, 2007 5:09:43 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:10:10 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CASP9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jxq.
| PDB = {{PDB2|1jxq}}, {{PDB2|1nw9}}, {{PDB2|2ar9}}, {{PDB2|3ygs}}
| Name = Caspase 9, apoptosis-related cysteine peptidase
| HGNCid = 1511
| Symbol = CASP9
| AltSymbols =; APAF-3; APAF3; CASPASE-9c; ICE-LAP6; MCH6
| OMIM = 602234
| ECnumber =
| Homologene = 31024
| MGIid = 1277950
| GeneAtlas_image1 = PBB_GE_CASP9_203984_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CASP9_210775_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0030693 |text = caspase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0008635 |text = caspase activation via cytochrome c}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 842
| Hs_Ensembl = ENSG00000132906
| Hs_RefseqProtein = NP_001220
| Hs_RefseqmRNA = NM_001229
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 15687322
| Hs_GenLoc_end = 15723527
| Hs_Uniprot = P55211
| Mm_EntrezGene = 12371
| Mm_Ensembl = ENSMUSG00000028914
| Mm_RefseqmRNA = NM_015733
| Mm_RefseqProtein = NP_056548
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 141065688
| Mm_GenLoc_end = 141088051
| Mm_Uniprot =
}}
}}
'''Caspase 9, apoptosis-related cysteine peptidase''', also known as '''CASP9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.<ref>{{cite web | title = Entrez Gene: CASP9 caspase 9, apoptosis-related cysteine peptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=842| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cohen GM |title=Caspases: the executioners of apoptosis. |journal=Biochem. J. |volume=326 ( Pt 1) |issue= |pages= 1-16 |year= 1997 |pmid= 9337844 |doi= }}
*{{cite journal | author=Deveraux QL, Reed JC |title=IAP family proteins--suppressors of apoptosis. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 239-52 |year= 1999 |pmid= 9990849 |doi= }}
*{{cite journal | author=Zhao LJ, Zhu H |title=Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design. |journal=Curr. Drug Targets Immune Endocr. Metabol. Disord. |volume=4 |issue= 4 |pages= 265-75 |year= 2005 |pmid= 15578977 |doi= }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CBL... {November 1, 2007 5:10:10 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein CBL image.jpg {November 1, 2007 5:11:28 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:11:43 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CBL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b47.
| PDB = {{PDB2|1b47}}, {{PDB2|1fbv}}, {{PDB2|1yvh}}, {{PDB2|2cbl}}, {{PDB2|2oo9}}
| Name = Cas-Br-M (murine) ecotropic retroviral transforming sequence
| HGNCid = 1541
| Symbol = CBL
| AltSymbols =; C-CBL; CBL2; RNF55
| OMIM = 165360
| ECnumber =
| Homologene = 3802
| MGIid = 88279
| GeneAtlas_image1 = PBB_GE_CBL_206607_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0048260 |text = positive regulation of receptor mediated endocytosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 867
| Hs_Ensembl = ENSG00000110395
| Hs_RefseqProtein = NP_005179
| Hs_RefseqmRNA = NM_005188
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 118582200
| Hs_GenLoc_end = 118684066
| Hs_Uniprot = P22681
| Mm_EntrezGene = 12402
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001001857
| Mm_RefseqProtein = XP_001001857
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cas-Br-M (murine) ecotropic retroviral transforming sequence''', also known as '''CBL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.<ref>{{cite web | title = Entrez Gene: CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=867| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smit L, Borst J |title=The Cbl family of signal transduction molecules. |journal=Critical reviews in oncogenesis |volume=8 |issue= 4 |pages= 359-79 |year= 1998 |pmid= 9622055 |doi= }}
*{{cite journal | author=Lupher ML, Andoniou CE, Bonita D, ''et al.'' |title=The c-Cbl oncoprotein. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 4 |pages= 439-44 |year= 1998 |pmid= 9675877 |doi= }}
*{{cite journal | author=Fang N, Fang D, Wang HY, ''et al.'' |title=Regulation of immune responses by E3 ubiquitin-protein ligases. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 161-75 |year= 2002 |pmid= 11826757 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CCNT1... {November 1, 2007 5:11:43 PM PDT} CREATE : Found no pages, creating new page. {November 1, 2007 5:13:46 PM PDT} CREATED : Created new protein page: CCNT1 {November 1, 2007 5:13:59 PM PDT} INFO : Beginning work on CD28... {November 1, 2007 5:13:59 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein CD28 image.jpg {November 1, 2007 5:15:22 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:15:39 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD28_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yjd.
| PDB = {{PDB2|1yjd}}
| Name = CD28 molecule
| HGNCid = 1653
| Symbol = CD28
| AltSymbols =; MGC138290; Tp44
| OMIM = 186760
| ECnumber =
| Homologene = 4473
| MGIid = 88327
| GeneAtlas_image1 = PBB_GE_CD28_211856_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD28_211861_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CD28_206545_at_tn.png
| Function = {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0042089 |text = cytokine biosynthetic process}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0045070 |text = positive regulation of viral genome replication}} {{GNF_GO|id=GO:0045086 |text = positive regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0045727 |text = positive regulation of protein biosynthetic process}} {{GNF_GO|id=GO:0045768 |text = positive regulation of anti-apoptosis}} {{GNF_GO|id=GO:0045840 |text = positive regulation of mitosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 940
| Hs_Ensembl = ENSG00000178562
| Hs_RefseqProtein = NP_006130
| Hs_RefseqmRNA = NM_006139
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 204279443
| Hs_GenLoc_end = 204310801
| Hs_Uniprot = P10747
| Mm_EntrezGene = 12487
| Mm_Ensembl = ENSMUSG00000026012
| Mm_RefseqmRNA = NM_007642
| Mm_RefseqProtein = NP_031668
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 60691012
| Mm_GenLoc_end = 60717905
| Mm_Uniprot = Q5SRG1
}}
}}
'''CD28 molecule''', also known as '''CD28''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CD28 CD28 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=940| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Linsley PS, Ledbetter JA |title=The role of the CD28 receptor during T cell responses to antigen. |journal=Annu. Rev. Immunol. |volume=11 |issue= |pages= 191-212 |year= 1993 |pmid= 8386518 |doi= 10.1146/annurev.iy.11.040193.001203 }}
*{{cite journal | author=Lenschow DJ, Walunas TL, Bluestone JA |title=CD28/B7 system of T cell costimulation. |journal=Annu. Rev. Immunol. |volume=14 |issue= |pages= 233-58 |year= 1996 |pmid= 8717514 |doi= 10.1146/annurev.immunol.14.1.233 }}
*{{cite journal | author=Greenfield EA, Nguyen KA, Kuchroo VK |title=CD28/B7 costimulation: a review. |journal=Crit. Rev. Immunol. |volume=18 |issue= 5 |pages= 389-418 |year= 1998 |pmid= 9784967 |doi= }}
*{{cite journal | author=Chang TT, Kuchroo VK, Sharpe AH |title=Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 113-30 |year= 2002 |pmid= 11826754 |doi= }}
*{{cite journal | author=Bour-Jordan H, Blueston JA |title=CD28 function: a balance of costimulatory and regulatory signals. |journal=J. Clin. Immunol. |volume=22 |issue= 1 |pages= 1-7 |year= 2002 |pmid= 11958588 |doi= }}
*{{cite journal | author=Greenway AL, Holloway G, McPhee DA, ''et al.'' |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 12734410 |doi= }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, ''et al.'' |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141-51 |year= 2004 |pmid= 15078178 |doi= }}
*{{cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 16091223 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CFH... {November 1, 2007 5:20:14 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein CFH image.jpg {November 1, 2007 5:21:18 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:21:50 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CFH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1haq.
| PDB = {{PDB2|1haq}}, {{PDB2|1hcc}}, {{PDB2|1hfh}}, {{PDB2|1hfi}}, {{PDB2|2bzm}}, {{PDB2|2g7i}}, {{PDB2|2ic4}}, {{PDB2|2jgw}}, {{PDB2|2jgx}}
| Name = Complement factor H
| HGNCid = 4883
| Symbol = CFH
| AltSymbols =; FH; FHL1; ARMD4; ARMS1; CFHL3; HF; HF1; HF2; HUS; MGC88246
| OMIM = 134370
| ECnumber =
| Homologene = 20086
| MGIid = 88385
| GeneAtlas_image1 = PBB_GE_CFH_215388_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CFH_213800_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006957 |text = complement activation, alternative pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3075
| Hs_Ensembl = ENSG00000000971
| Hs_RefseqProtein = NP_000177
| Hs_RefseqmRNA = NM_000186
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 194887631
| Hs_GenLoc_end = 194983257
| Hs_Uniprot = P08603
| Mm_EntrezGene = 12628
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001000306
| Mm_RefseqProtein = XP_001000306
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement factor H''', also known as '''CFH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: CFH complement factor H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3075| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pío R, Elsasser TH, Martínez A, Cuttitta F |title=Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma. |journal=Microsc. Res. Tech. |volume=57 |issue= 1 |pages= 23-7 |year= 2002 |pmid= 11921353 |doi= 10.1002/jemt.10047 }}
*{{cite journal | author=Rodríguez de Córdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, ''et al.'' |title=The human complement factor H: functional roles, genetic variations and disease associations. |journal=Mol. Immunol. |volume=41 |issue= 4 |pages= 355-67 |year= 2004 |pmid= 15163532 |doi= 10.1016/j.molimm.2004.02.005 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on DPP4... {November 1, 2007 5:15:39 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein DPP4 image.jpg {November 1, 2007 5:16:57 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:17:16 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DPP4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1j2e.
| PDB = {{PDB2|1j2e}}, {{PDB2|1n1m}}, {{PDB2|1nu6}}, {{PDB2|1nu8}}, {{PDB2|1pfq}}, {{PDB2|1r9m}}, {{PDB2|1r9n}}, {{PDB2|1rwq}}, {{PDB2|1tk3}}, {{PDB2|1tkr}}, {{PDB2|1u8e}}, {{PDB2|1w1i}}, {{PDB2|1wcy}}, {{PDB2|1x70}}, {{PDB2|2ajl}}, {{PDB2|2bgn}}, {{PDB2|2bgr}}, {{PDB2|2bub}}, {{PDB2|2fjp}}, {{PDB2|2g5p}}, {{PDB2|2g5t}}, {{PDB2|2g63}}, {{PDB2|2hha}}, {{PDB2|2i03}}, {{PDB2|2iit}}, {{PDB2|2iiv}}, {{PDB2|2ogz}}, {{PDB2|2oph}}, {{PDB2|2oqi}}, {{PDB2|2oqv}}, {{PDB2|2p8s}}
| Name = Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
| HGNCid = 3009
| Symbol = DPP4
| AltSymbols =; ADABP; ADCP2; CD26; DPPIV; TP103
| OMIM = 102720
| ECnumber =
| Homologene = 3279
| MGIid = 94919
| GeneAtlas_image1 = PBB_GE_DPP4_203717_at_tn.png
| GeneAtlas_image2 = PBB_GE_DPP4_203716_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DPP4_211478_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004177 |text = aminopeptidase activity}} {{GNF_GO|id=GO:0004274 |text = dipeptidyl-peptidase IV activity}} {{GNF_GO|id=GO:0004287 |text = prolyl oligopeptidase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0046581 |text = intercellular canaliculus}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1803
| Hs_Ensembl = ENSG00000197635
| Hs_RefseqProtein = NP_001926
| Hs_RefseqmRNA = NM_001935
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 162557005
| Hs_GenLoc_end = 162639298
| Hs_Uniprot = P27487
| Mm_EntrezGene = 13482
| Mm_Ensembl = ENSMUSG00000035000
| Mm_RefseqmRNA = NM_010074
| Mm_RefseqProtein = NP_034204
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 62130912
| Mm_GenLoc_end = 62213070
| Mm_Uniprot = Q3TR43
}}
}}
'''Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)''', also known as '''DPP4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.<ref>{{cite web | title = Entrez Gene: DPP4 dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1803| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ansorge S, Bühling F, Kähne T, ''et al.'' |title=CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. |journal=Adv. Exp. Med. Biol. |volume=421 |issue= |pages= 127-40 |year= 1997 |pmid= 9330689 |doi= }}
*{{cite journal | author=Reinhold D, Kähne T, Steinbrecher A, ''et al.'' |title=The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. |journal=Biol. Chem. |volume=383 |issue= 7-8 |pages= 1133-8 |year= 2003 |pmid= 12437097 |doi= }}
*{{cite journal | author=Sato K, Dang NH |title=CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). |journal=Int. J. Oncol. |volume=22 |issue= 3 |pages= 481-97 |year= 2003 |pmid= 12579300 |doi= }}
*{{cite journal | author=de Meester I, Lambeir AM, Proost P, Scharpé S |title=Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV. |journal=Adv. Exp. Med. Biol. |volume=524 |issue= |pages= 3-17 |year= 2003 |pmid= 12675218 |doi= }}
*{{cite journal | author=Koch S, Anthonsen D, Skovbjerg H, Sjöström H |title=On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. |journal=Adv. Exp. Med. Biol. |volume=524 |issue= |pages= 181-7 |year= 2003 |pmid= 12675238 |doi= }}
*{{cite journal | author=Pro B, Dang NH |title=CD26/dipeptidyl peptidase IV and its role in cancer. |journal=Histol. Histopathol. |volume=19 |issue= 4 |pages= 1345-51 |year= 2005 |pmid= 15375776 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on EPO... {November 1, 2007 5:17:16 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein EPO image.jpg {November 1, 2007 5:18:12 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:18:25 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1buy.
| PDB = {{PDB2|1buy}}, {{PDB2|1cn4}}, {{PDB2|1eer}}
| Name = Erythropoietin
| HGNCid = 3415
| Symbol = EPO
| AltSymbols =; EP; MGC138142
| OMIM = 133170
| ECnumber =
| Homologene = 624
| MGIid = 95407
| GeneAtlas_image1 = PBB_GE_EPO_207257_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPO_217254_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005128 |text = erythropoietin receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0043249 |text = erythrocyte maturation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2056
| Hs_Ensembl = ENSG00000130427
| Hs_RefseqProtein = NP_000790
| Hs_RefseqmRNA = NM_000799
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 100156359
| Hs_GenLoc_end = 100159257
| Hs_Uniprot = P01588
| Mm_EntrezGene = 13856
| Mm_Ensembl = ENSMUSG00000029711
| Mm_RefseqmRNA = NM_007942
| Mm_RefseqProtein = NP_031968
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 137712873
| Mm_GenLoc_end = 137714972
| Mm_Uniprot = Q0VED9
}}
}}
'''Erythropoietin''', also known as '''EPO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.<ref>{{cite web | title = Entrez Gene: EPO erythropoietin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2056| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Takeuchi M, Kobata A |title=Structures and functional roles of the sugar chains of human erythropoietins. |journal=Glycobiology |volume=1 |issue= 4 |pages= 337-46 |year= 1992 |pmid= 1820196 |doi= }}
*{{cite journal | author=Semba RD, Juul SE |title=Erythropoietin in human milk: physiology and role in infant health. |journal=Journal of human lactation : official journal of International Lactation Consultant Association |volume=18 |issue= 3 |pages= 252-61 |year= 2002 |pmid= 12192960 |doi= }}
*{{cite journal | author=Ratcliffe PJ |title=From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |journal=Blood Purif. |volume=20 |issue= 5 |pages= 445-50 |year= 2003 |pmid= 12207089 |doi= }}
*{{cite journal | author=Westenfelder C |title=Unexpected renal actions of erythropoietin. |journal=Exp. Nephrol. |volume=10 |issue= 5-6 |pages= 294-8 |year= 2003 |pmid= 12381912 |doi= }}
*{{cite journal | author=Becerra SP, Amaral J |title=Erythropoietin--an endogenous retinal survival factor. |journal=N. Engl. J. Med. |volume=347 |issue= 24 |pages= 1968-70 |year= 2002 |pmid= 12477950 |doi= 10.1056/NEJMcibr022629 }}
*{{cite journal | author=Genc S, Koroglu TF, Genc K |title=Erythropoietin and the nervous system. |journal=Brain Res. |volume=1000 |issue= 1-2 |pages= 19-31 |year= 2004 |pmid= 15053948 |doi= 10.1016/j.brainres.2003.12.037 }}
*{{cite journal | author=Fandrey J |title=Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=286 |issue= 6 |pages= R977-88 |year= 2004 |pmid= 15142852 |doi= 10.1152/ajpregu.00577.2003 }}
*{{cite journal | author=Juul S |title=Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models. |journal=Clinics in perinatology |volume=31 |issue= 1 |pages= 129-42 |year= 2004 |pmid= 15183662 |doi= 10.1016/j.clp.2004.03.004 }}
*{{cite journal | author=Buemi M, Caccamo C, Nostro L, ''et al.'' |title=Brain and cancer: the protective role of erythropoietin. |journal=Med Res Rev |volume=25 |issue= 2 |pages= 245-59 |year= 2005 |pmid= 15389732 |doi= 10.1002/med.20012 }}
*{{cite journal | author=Sytkowski AJ |title=Does erythropoietin have a dark side? Epo signaling and cancer cells. |journal=Sci. STKE |volume=2007 |issue= 395 |pages= pe38 |year= 2007 |pmid= 17636183 |doi= 10.1126/stke.3952007pe38 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on GJA1... {November 1, 2007 5:19:24 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein GJA1 image.jpg {November 1, 2007 5:19:58 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:20:14 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GJA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r5s.
| PDB = {{PDB2|1r5s}}
| Name = Gap junction protein, alpha 1, 43kDa
| HGNCid = 4274
| Symbol = GJA1
| AltSymbols =; CX43; DFNB38; GJAL; ODDD
| OMIM = 121014
| ECnumber =
| Homologene = 136
| MGIid = 95713
| GeneAtlas_image1 = PBB_GE_GJA1_201667_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}} {{GNF_GO|id=GO:0015285 |text = gap-junction channel activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005922 |text = connexon complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0016264 |text = gap junction assembly}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2697
| Hs_Ensembl = ENSG00000152661
| Hs_RefseqProtein = NP_000156
| Hs_RefseqmRNA = NM_000165
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 121798487
| Hs_GenLoc_end = 121812571
| Hs_Uniprot = P17302
| Mm_EntrezGene = 14609
| Mm_Ensembl = ENSMUSG00000050953
| Mm_RefseqmRNA = NM_010288
| Mm_RefseqProtein = NP_034418
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 56065745
| Mm_GenLoc_end = 56078825
| Mm_Uniprot = Q544I7
}}
}}
'''Gap junction protein, alpha 1, 43kDa''', also known as '''GJA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.<ref>{{cite web | title = Entrez Gene: GJA1 gap junction protein, alpha 1, 43kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2697| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Saffitz JE, Laing JG, Yamada KA |title=Connexin expression and turnover : implications for cardiac excitability. |journal=Circ. Res. |volume=86 |issue= 7 |pages= 723-8 |year= 2000 |pmid= 10764404 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on IKBKB... {November 1, 2007 5:21:50 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:23:22 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
| HGNCid = 5960
| Symbol = IKBKB
| AltSymbols =; FLJ40509; IKK-beta; IKK2; IKKB; MGC131801; NFKBIKB
| OMIM = 603258
| ECnumber =
| Homologene = 7782
| MGIid = 1338071
| GeneAtlas_image1 = PBB_GE_IKBKB_209341_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IKBKB_209342_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_IKBKB_211027_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001782 |text = B cell homeostasis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3551
| Hs_Ensembl = ENSG00000104365
| Hs_RefseqProtein = NP_001547
| Hs_RefseqmRNA = NM_001556
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 42247986
| Hs_GenLoc_end = 42309130
| Hs_Uniprot = O14920
| Mm_EntrezGene = 16150
| Mm_Ensembl = ENSMUSG00000031537
| Mm_RefseqmRNA = NM_010546
| Mm_RefseqProtein = NP_034676
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 24124758
| Mm_GenLoc_end = 24172108
| Mm_Uniprot = Q05DR8
}}
}}
'''Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta''', also known as '''IKBKB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3551| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ITGA2... {November 1, 2007 5:23:22 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein ITGA2 image.jpg {November 1, 2007 5:23:41 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:24:01 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aox.
| PDB = {{PDB2|1aox}}, {{PDB2|1dzi}}, {{PDB2|1v7p}}
| Name = Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
| HGNCid = 6137
| Symbol = ITGA2
| AltSymbols =; BR; CD49B; GPIa; VLA-2; VLAA2
| OMIM = 192974
| ECnumber =
| Homologene = 1662
| MGIid = 96600
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3673
| Hs_Ensembl = ENSG00000164171
| Hs_RefseqProtein = NP_002194
| Hs_RefseqmRNA = NM_002203
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 52321014
| Hs_GenLoc_end = 52423805
| Hs_Uniprot = P17301
| Mm_EntrezGene = 16398
| Mm_Ensembl = ENSMUSG00000015533
| Mm_RefseqmRNA = XM_982915
| Mm_RefseqProtein = XP_988009
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 115956703
| Mm_GenLoc_end = 116052930
| Mm_Uniprot = Q6P1C7
}}
}}
'''Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)''', also known as '''ITGA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.<ref>{{cite web | title = Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3673| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Moroi M, Jung SM |title=Platelet receptors for collagen. |journal=Thromb. Haemost. |volume=78 |issue= 1 |pages= 439-44 |year= 1997 |pmid= 9198193 |doi= }}
*{{cite journal | author=Takada Y, Kamata T, Irie A, ''et al.'' |title=Structural basis of integrin-mediated signal transduction. |journal=Matrix Biol. |volume=16 |issue= 4 |pages= 143-51 |year= 1998 |pmid= 9402003 |doi= }}
*{{cite journal | author=Dickeson SK, Santoro SA |title=Ligand recognition by the I domain-containing integrins. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 6 |pages= 556-66 |year= 1998 |pmid= 9676575 |doi= }}
*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390-6 |year= 1999 |pmid= 9789327 |doi= }}
*{{cite journal | author=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1-11 |year= 2003 |pmid= 12482545 |doi= }}
*{{cite journal | author=Charakida M, Tousoulis D, Stefanadis C, Toutouzas P |title=The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease. |journal=Italian heart journal : official journal of the Italian Federation of Cardiology |volume=4 |issue= 1 |pages= 17-22 |year= 2003 |pmid= 12690916 |doi= }}
*{{cite journal | author=Tsantes AE, Nikolopoulos GK, Bagos PG, ''et al.'' |title=Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis. |journal=Int. J. Cardiol. |volume=118 |issue= 2 |pages= 189-96 |year= 2007 |pmid= 17023078 |doi= 10.1016/j.ijcard.2006.06.047 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ITGA5... {November 1, 2007 5:24:01 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:24:38 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
| HGNCid = 6141
| Symbol = ITGA5
| AltSymbols =; CD49e; FNRA; VLA5A
| OMIM = 135620
| ECnumber =
| Homologene = 20508
| MGIid = 96604
| GeneAtlas_image1 = PBB_GE_ITGA5_201389_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}}
| Process = {{GNF_GO|id=GO:0007044 |text = cell-substrate junction assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007613 |text = memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3678
| Hs_Ensembl = ENSG00000161638
| Hs_RefseqProtein = NP_002196
| Hs_RefseqmRNA = NM_002205
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 53075316
| Hs_GenLoc_end = 53099317
| Hs_Uniprot = P08648
| Mm_EntrezGene = 16402
| Mm_Ensembl = ENSMUSG00000000555
| Mm_RefseqmRNA = NM_010577
| Mm_RefseqProtein = NP_034707
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 103172320
| Mm_GenLoc_end = 103194797
| Mm_Uniprot = Q3U7M6
}}
}}
'''Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)''', also known as '''ITGA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.<ref>{{cite web | title = Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3678| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ruoslahti E |title=Integrin signaling and matrix assembly. |journal=Tumour Biol. |volume=17 |issue= 2 |pages= 117-24 |year= 1996 |pmid= 8658014 |doi= }}
*{{cite journal | author=Coulombel L, Auffray I, Gaugler MH, Rosemblatt M |title=Expression and function of integrins on hematopoietic progenitor cells. |journal=Acta Haematol. |volume=97 |issue= 1-2 |pages= 13-21 |year= 1997 |pmid= 8980606 |doi= }}
*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390-6 |year= 1999 |pmid= 9789327 |doi= }}
*{{cite journal | author=Evans JP |title=Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. |journal=Bioessays |volume=23 |issue= 7 |pages= 628-39 |year= 2001 |pmid= 11462216 |doi= 10.1002/bies.1088 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on KCNH2... {November 1, 2007 5:24:38 PM PDT} UPLOAD : Added new Image to wiki: {November 1, 2007 5:26:10 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:26:33 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = <!-- Commented out because image was deleted: PBB_Protein_KCNH2_image.jpg -->
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1byw.
| PDB = {{PDB2|1byw}}, {{PDB2|1ujl}}
| Name = Potassium voltage-gated channel, subfamily H (eag-related), member 2
| HGNCid = 6251
| Symbol = KCNH2
| AltSymbols =; ERG1; HERG; HERG1; Kv11.1; LQT2; SQT1
| OMIM = 152427
| ECnumber =
| Homologene = 201
| MGIid = 1341722
| GeneAtlas_image1 = PBB_GE_KCNH2_205262_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNH2_210036_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_KCNH2_gnf1h06648_at_tn.png
| Function = {{GNF_GO|id=GO:0000155 |text = two-component sensor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005251 |text = delayed rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000160 |text = two-component signal transduction system (phosphorelay)}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3757
| Hs_Ensembl = ENSG00000055118
| Hs_RefseqProtein = NP_000229
| Hs_RefseqmRNA = NM_000238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 150272982
| Hs_GenLoc_end = 150306121
| Hs_Uniprot = Q12809
| Mm_EntrezGene = 16511
| Mm_Ensembl = ENSMUSG00000038319
| Mm_RefseqmRNA = XM_981382
| Mm_RefseqProtein = XP_986476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 23829654
| Mm_GenLoc_end = 23861669
| Mm_Uniprot = Q53Z09
}}
}}
'''Potassium voltage-gated channel, subfamily H (eag-related), member 2''', also known as '''KCNH2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.<ref>{{cite web | title = Entrez Gene: KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3757| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vincent GM |title=The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. |journal=Annu. Rev. Med. |volume=49 |issue= |pages= 263-74 |year= 1998 |pmid= 9509262 |doi= 10.1146/annurev.med.49.1.263 }}
*{{cite journal | author=Ackerman MJ |title=The long QT syndrome: ion channel diseases of the heart. |journal=Mayo Clin. Proc. |volume=73 |issue= 3 |pages= 250-69 |year= 1998 |pmid= 9511785 |doi= }}
*{{cite journal | author=Taglialatela M, Castaldo P, Pannaccione A, ''et al.'' |title=Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications. |journal=Biochem. Pharmacol. |volume=55 |issue= 11 |pages= 1741-6 |year= 1998 |pmid= 9714291 |doi= }}
*{{cite journal | author=Bjerregaard P, Gussak I |title=Short QT syndrome: mechanisms, diagnosis and treatment. |journal=Nature clinical practice. Cardiovascular medicine |volume=2 |issue= 2 |pages= 84-7 |year= 2005 |pmid= 16265378 |doi= 10.1038/ncpcardio0097 }}
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on LRP1... {November 1, 2007 5:26:33 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein LRP1 image.jpg {November 1, 2007 5:27:30 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:27:58 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LRP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cr8.
| PDB = {{PDB2|1cr8}}, {{PDB2|1d2l}}, {{PDB2|1j8e}}, {{PDB2|2fyj}}, {{PDB2|2fyl}}
| Name = Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
| HGNCid = 6692
| Symbol = LRP1
| AltSymbols =; LRP; A2MR; APOER; APR; CD91; FLJ16451; MGC88725; TGFBR5
| OMIM = 107770
| ECnumber =
| Homologene = 1744
| MGIid = 96828
| GeneAtlas_image1 = PBB_GE_LRP1_200785_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LRP1_200784_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008034 |text = lipoprotein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4035
| Hs_Ensembl = ENSG00000123384
| Hs_RefseqProtein = NP_002323
| Hs_RefseqmRNA = NM_002332
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 55808543
| Hs_GenLoc_end = 55893390
| Hs_Uniprot = Q07954
| Mm_EntrezGene = 16971
| Mm_Ensembl = ENSMUSG00000040249
| Mm_RefseqmRNA = NM_008512
| Mm_RefseqProtein = NP_032538
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 126941128
| Mm_GenLoc_end = 127024075
| Mm_Uniprot = Q3U454
}}
}}
'''Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)''', also known as '''LRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li Z, Dai J, Zheng H, ''et al.'' |title=An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. |journal=Front. Biosci. |volume=7 |issue= |pages= d731-51 |year= 2002 |pmid= 11861214 |doi= }}
*{{cite journal | author=van der Geer P |title=Phosphorylation of LRP1: regulation of transport and signal transduction. |journal=Trends Cardiovasc. Med. |volume=12 |issue= 4 |pages= 160-5 |year= 2002 |pmid= 12069755 |doi= }}
*{{cite journal | author=May P, Herz J |title=LDL receptor-related proteins in neurodevelopment. |journal=Traffic |volume=4 |issue= 5 |pages= 291-301 |year= 2004 |pmid= 12713657 |doi= }}
*{{cite journal | author=Llorente-Cortés V, Badimon L |title=LDL receptor-related protein and the vascular wall: implications for atherothrombosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 3 |pages= 497-504 |year= 2005 |pmid= 15705932 |doi= 10.1161/01.ATV.0000154280.62072.fd }}
*{{cite journal | author=Huang SS, Huang JS |title=TGF-beta control of cell proliferation. |journal=J. Cell. Biochem. |volume=96 |issue= 3 |pages= 447-62 |year= 2005 |pmid= 16088940 |doi= 10.1002/jcb.20558 }}
*{{cite journal | author=Lillis AP, Mikhailenko I, Strickland DK |title=Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1884-93 |year= 2005 |pmid= 16102056 |doi= 10.1111/j.1538-7836.2005.01371.x }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on NFKB2... {November 1, 2007 5:27:58 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein NFKB2 image.jpg {November 1, 2007 5:28:57 PM PDT} CREATE : Found no pages, creating new page. {November 1, 2007 5:29:32 PM PDT} CREATED : Created new protein page: NFKB2 {November 1, 2007 5:29:40 PM PDT} INFO : Beginning work on NPM1... {November 1, 2007 5:29:40 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein NPM1 image.jpg {November 1, 2007 5:30:14 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:30:33 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NPM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p1b.
| PDB = {{PDB2|2p1b}}
| Name = Nucleophosmin (nucleolar phosphoprotein B23, numatrin)
| HGNCid = 7910
| Symbol = NPM1
| AltSymbols =; B23; MGC104254; NPM
| OMIM = 164040
| ECnumber =
| Homologene = 87629
| MGIid = 3647121
| GeneAtlas_image1 = PBB_GE_NPM1_221691_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0030957 |text = Tat protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042255 |text = ribosome assembly}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4869
| Hs_Ensembl = ENSG00000181163
| Hs_RefseqProtein = NP_001032827
| Hs_RefseqmRNA = NM_001037738
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 170746725
| Hs_GenLoc_end = 170770492
| Hs_Uniprot = P06748
| Mm_EntrezGene = 434373
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_486188
| Mm_RefseqProtein = XP_486188
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nucleophosmin (nucleolar phosphoprotein B23, numatrin)''', also known as '''NPM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Gjerset RA |title=DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 239-51 |year= 2007 |pmid= 16855788 |doi= 10.1007/s10735-006-9040-y }}
*{{cite journal | author=Chen W, Rassidakis GZ, Medeiros LJ |title=Nucleophosmin gene mutations in acute myeloid leukemia. |journal=Arch. Pathol. Lab. Med. |volume=130 |issue= 11 |pages= 1687-92 |year= 2006 |pmid= 17076533 |doi= }}
*{{cite journal | author=Falini B, Nicoletti I, Bolli N, ''et al.'' |title=Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. |journal=Haematologica |volume=92 |issue= 4 |pages= 519-32 |year= 2007 |pmid= 17488663 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PLK1... {November 1, 2007 5:30:33 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein PLK1 image.jpg {November 1, 2007 5:31:32 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:31:45 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PLK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q4k.
| PDB = {{PDB2|1q4k}}, {{PDB2|1q4o}}, {{PDB2|1umw}}, {{PDB2|2ogq}}, {{PDB2|2ojs}}, {{PDB2|2ojx}}, {{PDB2|2ou7}}, {{PDB2|2owb}}
| Name = Polo-like kinase 1 (Drosophila)
| HGNCid = 9077
| Symbol = PLK1
| AltSymbols =; PLK; STPK13
| OMIM = 602098
| ECnumber =
| Homologene = 3690
| MGIid = 97621
| GeneAtlas_image1 = PBB_GE_PLK1_202240_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLK1_gnf1h09404_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5347
| Hs_Ensembl = ENSG00000166851
| Hs_RefseqProtein = NP_005021
| Hs_RefseqmRNA = NM_005030
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 23597692
| Hs_GenLoc_end = 23609188
| Hs_Uniprot = P53350
| Mm_EntrezGene = 18817
| Mm_Ensembl = ENSMUSG00000030867
| Mm_RefseqmRNA = NM_011121
| Mm_RefseqProtein = NP_035251
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 121950586
| Mm_GenLoc_end = 121960987
| Mm_Uniprot = Q3TPZ2
}}
}}
'''Polo-like kinase 1 (Drosophila)''', also known as '''PLK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PTK2B... {November 1, 2007 5:18:25 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:19:24 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PTK2B protein tyrosine kinase 2 beta
| HGNCid = 9612
| Symbol = PTK2B
| AltSymbols =; PKB; CADTK; CAKB; FADK2; FAK2; PTK; PYK2; RAFTK
| OMIM = 601212
| ECnumber =
| Homologene = 23001
| MGIid = 104908
| GeneAtlas_image1 = PBB_GE_PTK2B_203110_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007172 |text = signal complex assembly}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2185
| Hs_Ensembl = ENSG00000120899
| Hs_RefseqProtein = NP_004094
| Hs_RefseqmRNA = NM_004103
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 27238971
| Hs_GenLoc_end = 27372824
| Hs_Uniprot = Q14289
| Mm_EntrezGene = 19229
| Mm_Ensembl = ENSMUSG00000059456
| Mm_RefseqmRNA = XM_994666
| Mm_RefseqProtein = XP_999760
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 65107372
| Mm_GenLoc_end = 65235162
| Mm_Uniprot = Q3UDE9
}}
}}
'''PTK2B protein tyrosine kinase 2 beta''', also known as '''PTK2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: PTK2B PTK2B protein tyrosine kinase 2 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2185| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Avraham S, Avraham H |title=Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells. |journal=Leuk. Lymphoma |volume=27 |issue= 3-4 |pages= 247-56 |year= 1998 |pmid= 9402324 |doi= }}
*{{cite journal | author=Schlaepfer DD, Hauck CR, Sieg DJ |title=Signaling through focal adhesion kinase. |journal=Prog. Biophys. Mol. Biol. |volume=71 |issue= 3-4 |pages= 435-78 |year= 1999 |pmid= 10354709 |doi= }}
*{{cite journal | author=Loeser RF |title=Integrins and cell signaling in chondrocytes. |journal=Biorheology |volume=39 |issue= 1-2 |pages= 119-24 |year= 2002 |pmid= 12082274 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PTPRC... {November 1, 2007 5:31:46 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein PTPRC image.jpg {November 1, 2007 5:33:24 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:33:44 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTPRC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ygr.
| PDB = {{PDB2|1ygr}}, {{PDB2|1ygu}}
| Name = Protein tyrosine phosphatase, receptor type, C
| HGNCid = 9666
| Symbol = PTPRC
| AltSymbols =; LCA; B220; CD45; GP180; LY5; T200
| OMIM = 151460
| ECnumber =
| Homologene = 2126
| MGIid = 97810
| GeneAtlas_image1 = PBB_GE_PTPRC_212588_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTPRC_207238_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTPRC_212587_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}}
| Process = {{GNF_GO|id=GO:0001915 |text = negative regulation of T cell mediated cytotoxicity}} {{GNF_GO|id=GO:0001960 |text = negative regulation of cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}} {{GNF_GO|id=GO:0042100 |text = B cell proliferation}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0045860 |text = positive regulation of protein kinase activity}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0050853 |text = B cell receptor signaling pathway}} {{GNF_GO|id=GO:0050857 |text = positive regulation of antigen receptor-mediated signaling pathway}} {{GNF_GO|id=GO:0051209 |text = release of sequestered calcium ion into cytosol}} {{GNF_GO|id=GO:0051607 |text = defense response to virus}} {{GNF_GO|id=GO:0051726 |text = regulation of cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5788
| Hs_Ensembl = ENSG00000081237
| Hs_RefseqProtein = NP_002829
| Hs_RefseqmRNA = NM_002838
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 196874424
| Hs_GenLoc_end = 196993035
| Hs_Uniprot = P08575
| Mm_EntrezGene = 19264
| Mm_Ensembl = ENSMUSG00000026395
| Mm_RefseqmRNA = NM_011210
| Mm_RefseqProtein = NP_035340
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 139879826
| Mm_GenLoc_end = 139991716
| Mm_Uniprot = Q5XFY7
}}
}}
'''Protein tyrosine phosphatase, receptor type, C''', also known as '''PTPRC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.<ref>{{cite web | title = Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5788| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tchilian EZ, Beverley PC |title=CD45 in memory and disease. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=50 |issue= 2 |pages= 85-93 |year= 2002 |pmid= 12022705 |doi= }}
*{{cite journal | author=Ishikawa H, Tsuyama N, Abroun S, ''et al.'' |title=Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation. |journal=Leuk. Lymphoma |volume=44 |issue= 9 |pages= 1477-81 |year= 2004 |pmid= 14565647 |doi= }}
*{{cite journal | author=Stanton T, Boxall S, Bennett A, ''et al.'' |title=CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans. |journal=Immunogenetics |volume=56 |issue= 2 |pages= 107-10 |year= 2004 |pmid= 15057492 |doi= 10.1007/s00251-004-0668-z }}
*{{cite journal | author=Huntington ND, Tarlinton DM |title=CD45: direct and indirect government of immune regulation. |journal=Immunol. Lett. |volume=94 |issue= 3 |pages= 167-74 |year= 2005 |pmid= 15275963 |doi= 10.1016/j.imlet.2004.05.011 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on RARA... {November 1, 2007 5:33:44 PM PDT} UPLOAD : Added new Image to wiki: {November 1, 2007 5:35:16 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:35:32 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RARA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dkf.
| PDB = {{PDB2|1dkf}}, {{PDB2|1dsz}}, {{PDB2|1hra}}
| Name = Retinoic acid receptor, alpha
| HGNCid = 9864
| Symbol = RARA
| AltSymbols =; NR1B1; RAR
| OMIM = 180240
| ECnumber =
| Homologene = 20262
| MGIid = 97856
| GeneAtlas_image1 = PBB_GE_RARA_203749_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RARA_203750_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RARA_211605_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003708 |text = retinoic acid receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5914
| Hs_Ensembl = ENSG00000131759
| Hs_RefseqProtein = NP_001028775
| Hs_RefseqmRNA = NM_001033603
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35718972
| Hs_GenLoc_end = 35767420
| Hs_Uniprot = P10276
| Mm_EntrezGene = 19401
| Mm_Ensembl = ENSMUSG00000037992
| Mm_RefseqmRNA = NM_009024
| Mm_RefseqProtein = NP_033050
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98753808
| Mm_GenLoc_end = 98791028
| Mm_Uniprot = Q3U3R3
}}
}}
'''Retinoic acid receptor, alpha''', also known as '''RARA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Petkovich M, Brand NJ, Krust A, Chambon P |title=A human retinoic acid receptor which belongs to the family of nuclear receptors. |journal=Nature |volume=330 |issue= 6147 |pages= 444-50 |year= 1988 |pmid= 2825025 |doi= 10.1038/330444a0 }}
*{{cite journal | author=Sirulnik A, Melnick A, Zelent A, Licht JD |title=Molecular pathogenesis of acute promyelocytic leukaemia and APL variants. |journal=Best practice & research. Clinical haematology |volume=16 |issue= 3 |pages= 387-408 |year= 2004 |pmid= 12935958 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SELE... {November 1, 2007 5:35:32 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein SELE image.jpg {November 1, 2007 5:36:08 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:36:27 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SELE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1esl.
| PDB = {{PDB2|1esl}}, {{PDB2|1g1t}}
| Name = Selectin E (endothelial adhesion molecule 1)
| HGNCid = 10718
| Symbol = SELE
| AltSymbols =; CD62E; ELAM; ELAM1; ESEL; LECAM2
| OMIM = 131210
| ECnumber =
| Homologene = 389
| MGIid = 98278
| GeneAtlas_image1 = PBB_GE_SELE_206211_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6401
| Hs_Ensembl = ENSG00000007908
| Hs_RefseqProtein = NP_000441
| Hs_RefseqmRNA = NM_000450
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 167958406
| Hs_GenLoc_end = 167969827
| Hs_Uniprot = P16581
| Mm_EntrezGene = 20339
| Mm_Ensembl = ENSMUSG00000026582
| Mm_RefseqmRNA = NM_011345
| Mm_RefseqProtein = NP_035475
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 165884909
| Mm_GenLoc_end = 165894352
| Mm_Uniprot = Q3U5F6
}}
}}
'''Selectin E (endothelial adhesion molecule 1)''', also known as '''SELE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The endothelial leukocyte adhesion molecule-1 is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. This gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.<ref>{{cite web | title = Entrez Gene: SELE selectin E (endothelial adhesion molecule 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6401| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33-7 |year= 1992 |pmid= 1375831 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SLC6A3... {November 1, 2007 5:36:27 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 1, 2007 5:37:01 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
| HGNCid = 11049
| Symbol = SLC6A3
| AltSymbols =; DAT; DAT1
| OMIM = 126455
| ECnumber =
| Homologene = 55547
| MGIid = 94862
| GeneAtlas_image1 = PBB_GE_SLC6A3_206836_at_tn.png
| Function = {{GNF_GO|id=GO:0005330 |text = dopamine:sodium symporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008504 |text = monoamine transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0015844 |text = monoamine transport}} {{GNF_GO|id=GO:0015872 |text = dopamine transport}} {{GNF_GO|id=GO:0042053 |text = regulation of dopamine metabolic process}} {{GNF_GO|id=GO:0042416 |text = dopamine biosynthetic process}} {{GNF_GO|id=GO:0042420 |text = dopamine catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6531
| Hs_Ensembl = ENSG00000142319
| Hs_RefseqProtein = NP_001035
| Hs_RefseqmRNA = NM_001044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 1445914
| Hs_GenLoc_end = 1498545
| Hs_Uniprot = Q01959
| Mm_EntrezGene = 13162
| Mm_Ensembl = ENSMUSG00000021609
| Mm_RefseqmRNA = NM_010020
| Mm_RefseqProtein = NP_034150
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 74002749
| Mm_GenLoc_end = 74044674
| Mm_Uniprot = Q3UVW5
}}
}}
'''Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3''', also known as '''SLC6A3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Uhl GR, Hall FS, Sora I |title=Cocaine, reward, movement and monoamine transporters. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 21-6 |year= 2002 |pmid= 11803442 |doi= 10.1038/sj/mp/4000964 }}
*{{cite journal | author=Ueno S |title=Genetic polymorphisms of serotonin and dopamine transporters in mental disorders. |journal=J. Med. Invest. |volume=50 |issue= 1-2 |pages= 25-31 |year= 2003 |pmid= 12630565 |doi= }}
*{{cite journal | author=Sidhu A, Wersinger C, Vernier P |title=alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. |journal=FEBS Lett. |volume=565 |issue= 1-3 |pages= 1-5 |year= 2004 |pmid= 15135042 |doi= 10.1016/j.febslet.2004.03.063 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TGFBR2... {November 1, 2007 5:37:01 PM PDT} UPLOAD : Added new Image to wiki: File:PBB Protein TGFBR2 image.jpg {November 3, 2007 1:12:50 PM PDT} AMBIGUITY : Did not locate an acceptable page to update. {November 3, 2007 1:15:04 PM PDT} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TGFBR2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ktz.
| PDB = {{PDB2|1ktz}}, {{PDB2|1m9z}}, {{PDB2|1plo}}
| Name = Transforming growth factor, beta receptor II (70/80kDa)
| HGNCid = 11773
| Symbol = TGFBR2
| AltSymbols =; AAT3; FAA3; HNPCC6; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
| OMIM = 190182
| ECnumber =
| Homologene = 2435
| MGIid = 98729
| GeneAtlas_image1 = PBB_GE_TGFBR2_208944_at_tn.png
| GeneAtlas_image2 = PBB_GE_TGFBR2_207334_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005026 |text = transforming growth factor beta receptor activity, type II}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7048
| Hs_Ensembl = ENSG00000163513
| Hs_RefseqProtein = NP_001020018
| Hs_RefseqmRNA = NM_001024847
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 30622998
| Hs_GenLoc_end = 30710635
| Hs_Uniprot = P37173
| Mm_EntrezGene = 21813
| Mm_Ensembl = ENSMUSG00000032440
| Mm_RefseqmRNA = NM_009371
| Mm_RefseqProtein = NP_033397
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 115932995
| Mm_GenLoc_end = 116023987
| Mm_Uniprot = Q9JLZ4
}}
}}
'''Transforming growth factor, beta receptor II (70/80kDa)''', also known as '''TGFBR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.<ref>{{cite web | title = Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7048| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TSHR... {November 3, 2007 1:15:04 PM PDT} CREATE : Found no pages, creating new page. {November 3, 2007 1:16:28 PM PDT} CREATED : Created new protein page: TSHR {November 3, 2007 1:16:46 PM PDT} end log.
{November 1, 2007 5:35:16 PM PDT} 
