- INFO: Beginning work on BRCA1... {April 10, 2008 4:25:11 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {April 10, 2008 4:25:51 PM PDT}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BRCA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jm7.
| PDB = {{PDB2|1jm7}}, {{PDB2|1jnx}}, {{PDB2|1n5o}}, {{PDB2|1oqa}}, {{PDB2|1t15}}, {{PDB2|1t29}}, {{PDB2|1t2u}}, {{PDB2|1t2v}}, {{PDB2|1y98}}
| Name = Breast cancer 1, early onset
| HGNCid = 1100
| Symbol = BRCA1
| AltSymbols =; BRCAI; BRCC1; IRIS; PSCP; RNF53
| OMIM = 113705
| ECnumber =
| Homologene = 5276
| MGIid = 104537
| GeneAtlas_image1 = PBB_GE_BRCA1_204531_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BRCA1_211851_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}{{GNF_GO|id=GO:0003677 |text = DNA binding}}{{GNF_GO|id=GO:0003684 |text = damaged DNA binding}}{{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}{{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}}{{GNF_GO|id=GO:0005515 |text = protein binding}}{{GNF_GO|id=GO:0008270 |text = zinc ion binding}}{{GNF_GO|id=GO:0015631 |text = tubulin binding}}{{GNF_GO|id=GO:0019899 |text = enzyme binding}}{{GNF_GO|id=GO:0046872 |text = metal ion binding}}{{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008274 |text = gamma-tubulin ring complex}} {{GNF_GO|id=GO:0031436 |text = BRCA1-BARD1 complex}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006359 |text = regulation of transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006978 |text = DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}} {{GNF_GO|id=GO:0008630 |text = DNA damage response, signal transduction resulting in induction of apoptosis}} {{GNF_GO|id=GO:0009048 |text = dosage compensation, by inactivation of X chromosome}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045717 |text = negative regulation of fatty acid biosynthetic process}} {{GNF_GO|id=GO:0045739 |text = positive regulation of DNA repair}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0046600 |text = negative regulation of centriole replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 672
| Hs_Ensembl = ENSG00000012048
| Hs_RefseqProtein = NP_009225
| Hs_RefseqmRNA = NM_007294
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 38449840
| Hs_GenLoc_end = 38530994
| Hs_Uniprot = P38398
| Mm_EntrezGene = 12189
| Mm_Ensembl = ENSMUSG00000017146
| Mm_RefseqmRNA = NM_009764
| Mm_RefseqProtein = NP_033894
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 101305657
| Mm_GenLoc_end = 101367902
| Mm_Uniprot = Q3UMS5
}}
}}
'''Breast cancer 1, early onset''', also known as '''BRCA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRCA1 breast cancer 1, early onset| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=672| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.<ref name="entrez">{{cite web | title = Entrez Gene: BRCA1 breast cancer 1, early onset| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=672| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Teng LS, Zheng Y, Wang HH |title=BRCA1/2 associated hereditary breast cancer. |journal=Journal of Zhejiang University. Science. B |volume=9 |issue= 2 |pages= 85-9 |year= 2008 |pmid= 18257128 |doi= 10.1631/jzus.B0710617 }}
*{{cite journal | author=Weischer M, Bojesen SE, Ellervik C, ''et al.'' |title=CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. |journal=J. Clin. Oncol. |volume=26 |issue= 4 |pages= 542-8 |year= 2008 |pmid= 18172190 |doi= 10.1200/JCO.2007.12.5922 }}
*{{cite journal | author=Fackenthal JD, Olopade OI |title=Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. |journal=Nat. Rev. Cancer |volume=7 |issue= 12 |pages= 937-48 |year= 2008 |pmid= 18034184 |doi= 10.1038/nrc2054 }}
*{{cite journal | author=Friedenson B |title=The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. |journal=BMC Cancer |volume=7 |issue= |pages= 152 |year= 2007 |pmid= 17683622 |doi= 10.1186/1471-2407-7-152 }}
*{{cite journal | author=Ferla R, Calò V, Cascio S, ''et al.'' |title=Founder mutations in BRCA1 and BRCA2 genes. |journal=Ann. Oncol. |volume=18 Suppl 6 |issue= |pages= vi93-8 |year= 2007 |pmid= 17591843 |doi= 10.1093/annonc/mdm234 }}
*{{cite journal | author=Mullan PB, Quinn JE, Harkin DP |title=The role of BRCA1 in transcriptional regulation and cell cycle control. |journal=Oncogene |volume=25 |issue= 43 |pages= 5854-63 |year= 2006 |pmid= 16998500 |doi= 10.1038/sj.onc.1209872 }}
*{{cite journal | author=Turner NC, Reis-Filho JS |title=Basal-like breast cancer and the BRCA1 phenotype. |journal=Oncogene |volume=25 |issue= 43 |pages= 5846-53 |year= 2006 |pmid= 16998499 |doi= 10.1038/sj.onc.1209876 }}
*{{cite journal | author=Honrado E, Osorio A, Palacios J, Benitez J |title=Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations. |journal=Oncogene |volume=25 |issue= 43 |pages= 5837-45 |year= 2006 |pmid= 16998498 |doi= 10.1038/sj.onc.1209875 }}
*{{cite journal | author=Domchek SM, Weber BL |title=Clinical management of BRCA1 and BRCA2 mutation carriers. |journal=Oncogene |volume=25 |issue= 43 |pages= 5825-31 |year= 2006 |pmid= 16998496 |doi= 10.1038/sj.onc.1209881 }}
*{{cite journal | author=Starita LM, Parvin JD |title=Substrates of the BRCA1-dependent ubiquitin ligase. |journal=Cancer Biol. Ther. |volume=5 |issue= 2 |pages= 137-41 |year= 2006 |pmid= 16479151 |doi= }}
*{{cite journal | author=Lee Y, Medeiros F, Kindelberger D, ''et al.'' |title=Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the pathogenesis of ovarian cancer. |journal=Advances in anatomic pathology |volume=13 |issue= 1 |pages= 1-7 |year= 2006 |pmid= 16462151 |doi= 10.1097/01.pap.0000201826.46978.e5 }}
*{{cite journal | author=Rosen EM, Fan S, Isaacs C |title=BRCA1 in hormonal carcinogenesis: basic and clinical research. |journal=Endocr. Relat. Cancer |volume=12 |issue= 3 |pages= 533-48 |year= 2005 |pmid= 16172191 |doi= 10.1677/erc.1.00972 }}
*{{cite journal | author=Durant ST, Nickoloff JA |title=Good timing in the cell cycle for precise DNA repair by BRCA1. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1216-22 |year= 2006 |pmid= 16103751 |doi= }}
*{{cite journal | author=Gonçalves A, Viens P, Sobol H, ''et al.'' |title=[Molecular alterations in breast cancer: clinical implications and new analytical tools] |journal=La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne |volume=26 |issue= 6 |pages= 470-8 |year= 2005 |pmid= 15936476 |doi= 10.1016/j.revmed.2004.11.012 }}
*{{cite journal | author=Dumitrescu RG, Cotarla I |title=Understanding breast cancer risk -- where do we stand in 2005? |journal=J. Cell. Mol. Med. |volume=9 |issue= 1 |pages= 208-21 |year= 2005 |pmid= 15784178 |doi= }}
*{{cite journal | author=Aiyar S, Sun JL, Li R |title=BRCA1: a locus-specific "liaison" in gene expression and genetic integrity. |journal=J. Cell. Biochem. |volume=94 |issue= 6 |pages= 1103-11 |year= 2005 |pmid= 15723343 |doi= 10.1002/jcb.20386 }}
*{{cite journal | author=Sunpaweravong S, Sunpaweravong P |title=Recent developments in critical genes in the molecular biology of breast cancer. |journal=Asian journal of surgery / Asian Surgical Association |volume=28 |issue= 1 |pages= 71-5 |year= 2005 |pmid= 15691805 |doi= }}
*{{cite journal | author=Feunteun J |title=[A paradox and three egnimas about the role of BRCA1 in breast and ovarian cancers] |journal=J. Soc. Biol. |volume=198 |issue= 2 |pages= 123-6 |year= 2004 |pmid= 15368961 |doi= }}
*{{cite journal | author=Olopade OI, Artioli G |title=Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations. |journal=The breast journal |volume=10 Suppl 1 |issue= |pages= S5-9 |year= 2004 |pmid= 14984481 |doi= }}
*{{cite journal | author=Modugno F |title=Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review. |journal=Am. J. Epidemiol. |volume=159 |issue= 4 |pages= 319-35 |year= 2004 |pmid= 14769635 |doi= }}
*{{cite journal | author=Levine DA, Argenta PA, Yee CJ, ''et al.'' |title=Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. |journal=J. Clin. Oncol. |volume=21 |issue= 22 |pages= 4222-7 |year= 2003 |pmid= 14615451 |doi= 10.1200/JCO.2003.04.131 }}
*{{cite journal | author=McCoy ML, Mueller CR, Roskelley CD |title=The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer. |journal=Reprod. Biol. Endocrinol. |volume=1 |issue= |pages= 72 |year= 2004 |pmid= 14613551 |doi= 10.1186/1477-7827-1-72 }}
*{{cite journal | author=Rosen EM, Fan S, Pestell RG, Goldberg ID |title=BRCA1 in hormone-responsive cancers. |journal=Trends Endocrinol. Metab. |volume=14 |issue= 8 |pages= 378-85 |year= 2004 |pmid= 14516936 |doi= }}
*{{cite journal | author=Hartman AR, Ford JM |title=BRCA1 and p53: compensatory roles in DNA repair. |journal=J. Mol. Med. |volume=81 |issue= 11 |pages= 700-7 |year= 2004 |pmid= 13679996 |doi= 10.1007/s00109-003-0477-0 }}
*{{cite journal | author=Mullineaux LG, Castellano TM, Shaw J, ''et al.'' |title=Identification of germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado. |journal=Cancer |volume=98 |issue= 3 |pages= 597-602 |year= 2003 |pmid= 12879478 |doi= 10.1002/cncr.11533 }}
*{{cite journal | author=Rosen EM, Fan S, Pestell RG, Goldberg ID |title=BRCA1 gene in breast cancer. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 19-41 |year= 2003 |pmid= 12767038 |doi= 10.1002/jcp.10257 }}
*{{cite journal | author=Lou Z, Chen J |title=BRCA proteins and DNA damage checkpoints. |journal=Front. Biosci. |volume=8 |issue= |pages= s718-21 |year= 2004 |pmid= 12700125 |doi= }}
*{{cite journal | author=Deng CX, Wang RH |title=Roles of BRCA1 in DNA damage repair: a link between development and cancer. |journal=Hum. Mol. Genet. |volume=12 Spec No 1 |issue= |pages= R113-23 |year= 2003 |pmid= 12668603 |doi= }}
*{{cite journal | author=Somasundaram K |title=Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair--perhaps through transcription. |journal=J. Cell. Biochem. |volume=88 |issue= 6 |pages= 1084-91 |year= 2003 |pmid= 12647291 |doi= 10.1002/jcb.10469 }}
*{{cite journal | author=El-Deiry WS |title=Transactivation of repair genes by BRCA1. |journal=Cancer Biol. Ther. |volume=1 |issue= 5 |pages= 490-1 |year= 2003 |pmid= 12496474 |doi= }}
*{{cite journal | author=Tutt A, Ashworth A |title=The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. |journal=Trends in molecular medicine |volume=8 |issue= 12 |pages= 571-6 |year= 2003 |pmid= 12470990 |doi= }}
*{{cite journal | author=Kubista M, Rosner M, Miloloza A, ''et al.'' |title=Brca1 and differentiation. |journal=Mutat. Res. |volume=512 |issue= 2-3 |pages= 165-72 |year= 2003 |pmid= 12464350 |doi= }}
*{{cite journal | author=Daniel DC |title=Highlight: BRCA1 and BRCA2 proteins in breast cancer. |journal=Microsc. Res. Tech. |volume=59 |issue= 1 |pages= 68-83 |year= 2002 |pmid= 12242698 |doi= 10.1002/jemt.10178 }}
*{{cite journal | author=Deng CX |title=Roles of BRCA1 in centrosome duplication. |journal=Oncogene |volume=21 |issue= 40 |pages= 6222-7 |year= 2002 |pmid= 12214252 |doi= 10.1038/sj.onc.1205713 }}
*{{cite journal | author=McGowan CH |title=Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor. |journal=Bioessays |volume=24 |issue= 6 |pages= 502-11 |year= 2002 |pmid= 12111733 |doi= 10.1002/bies.10101 }}
*{{cite journal | author=Miyoshi Y, Noguchi S |title=[Genetic test and prophylactic treatment in breast cancer families] |journal=Gan To Kagaku Ryoho |volume=29 |issue= 4 |pages= 512-22 |year= 2002 |pmid= 11977534 |doi= }}
*{{cite journal | author=Levine DA, Boyd J |title=The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. |journal=Cancer Res. |volume=61 |issue= 3 |pages= 908-11 |year= 2001 |pmid= 11221880 |doi= }}
*{{cite journal | author=Deng CX, Brodie SG |title=Roles of BRCA1 and its interacting proteins. |journal=Bioessays |volume=22 |issue= 8 |pages= 728-37 |year= 2000 |pmid= 10918303 |doi= 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B }}
*{{cite journal | author=Yang X, Lippman ME |title=BRCA1 and BRCA2 in breast cancer. |journal=Breast Cancer Res. Treat. |volume=54 |issue= 1 |pages= 1-10 |year= 1999 |pmid= 10369075 |doi= }}
*{{cite journal | author=Paterson JW |title=BRCA1: a review of structure and putative functions. |journal=Dis. Markers |volume=13 |issue= 4 |pages= 261-74 |year= 1998 |pmid= 9553742 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL2A1... {April 10, 2008 4:25:51 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {April 10, 2008 4:26:11 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL2A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u5m.
| PDB = {{PDB2|1u5m}}
| Name = Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
| HGNCid = 2200
| Symbol = COL2A1
| AltSymbols =; AOM; COL11A3; MGC131516; SEDC
| OMIM = 120140
| ECnumber =
| Homologene = 55607
| MGIid = 88452
| GeneAtlas_image1 = PBB_GE_COL2A1_213492_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL2A1_217404_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005584 |text = collagen type I}} {{GNF_GO|id=GO:0005585 |text = collagen type II}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1280
| Hs_Ensembl = ENSG00000139219
| Hs_RefseqProtein = NP_001835
| Hs_RefseqmRNA = NM_001844
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 46653018
| Hs_GenLoc_end = 46684528
| Hs_Uniprot = P02458
| Mm_EntrezGene = 12824
| Mm_Ensembl = ENSMUSG00000022483
| Mm_RefseqmRNA = NM_031163
| Mm_RefseqProtein = NP_112440
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 97803005
| Mm_GenLoc_end = 97832691
| Mm_Uniprot = Q61428
}}
}}
'''Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)''', also known as '''COL2A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COL2A1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1280| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: COL2A1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1280| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Liberfarb RM, Levy HP, Rose PS, ''et al.'' |title=The Stickler syndrome: genotype/phenotype correlation in 10 families with Stickler syndrome resulting from seven mutations in the type II collagen gene locus COL2A1. |journal=Genet. Med. |volume=5 |issue= 1 |pages= 21-7 |year= 2003 |pmid= 12544472 |doi= 10.1097/01.GIM.0000048704.65405.D8 }}
*{{cite journal | author=Bachiller FG, Caballer AP, Portal LF |title=Avascular necrosis of the femoral head after femoral neck fracture. |journal=Clin. Orthop. Relat. Res. |volume= |issue= 399 |pages= 87-109 |year= 2002 |pmid= 12011698 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kuivaniemi H, Tromp G, Prockop DJ |title=Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. |journal=Hum. Mutat. |volume=9 |issue= 4 |pages= 300-15 |year= 1997 |pmid= 9101290 |doi= 10.1002/(SICI)1098-1004(1997)9:4<300::AID-HUMU2>3.0.CO;2-9 }}
*{{cite journal | author=Kuivaniemi H, Tromp G, Prockop DJ |title=Mutations in collagen genes: causes of rare and some common diseases in humans. |journal=FASEB J. |volume=5 |issue= 7 |pages= 2052-60 |year= 1991 |pmid= 2010058 |doi= }}
*{{cite journal | author= |title=A comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group. |journal=Science |volume=258 |issue= 5079 |pages= 67-86 |year= 1992 |pmid= 1439770 |doi= }}
*{{cite journal | author=Olavarrieta L, Morales-Angulo C, del Castillo I, ''et al.'' |title=Stickler and branchio-oto-renal syndromes in a patient with mutations in EYA1 and COL2A1 genes. |journal=Clin. Genet. |volume=73 |issue= 3 |pages= 262-7 |year= 2008 |pmid= 18177466 |doi= 10.1111/j.1399-0004.2007.00947.x }}
*{{cite journal | author=Miyamoto C, Matsumoto T, Sakimura K, Shindo H |title=Osteogenic protein-1 with transforming growth factor-beta1: potent inducer of chondrogenesis of synovial mesenchymal stem cells in vitro. |journal=Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association |volume=12 |issue= 6 |pages= 555-61 |year= 2008 |pmid= 18040638 |doi= 10.1007/s00776-007-1176-4 }}
*{{cite journal | author=Forzano F, Lituania M, Viassolo A, ''et al.'' |title=A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and "patchy" expression in the mosaic father. |journal=Am. J. Med. Genet. A |volume=143 |issue= 23 |pages= 2815-20 |year= 2008 |pmid= 17994563 |doi= 10.1002/ajmg.a.32047 }}
*{{cite journal | author=McAlinden A, Majava M, Bishop PN, ''et al.'' |title=Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome. |journal=Hum. Mutat. |volume=29 |issue= 1 |pages= 83-90 |year= 2008 |pmid= 17721977 |doi= 10.1002/humu.20603 }}
*{{cite journal | author=Tchetina EV, Di Battista JA, Zukor DJ, ''et al.'' |title=Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. |journal=Arthritis Res. Ther. |volume=9 |issue= 4 |pages= R75 |year= 2008 |pmid= 17683641 |doi= 10.1186/ar2273 }}
*{{cite journal | author=Mutti DO, Cooper ME, O'Brien S, ''et al.'' |title=Candidate gene and locus analysis of myopia. |journal=Mol. Vis. |volume=13 |issue= |pages= 1012-9 |year= 2007 |pmid= 17653045 |doi= }}
*{{cite journal | author=McAlinden A, Liang L, Mukudai Y, ''et al.'' |title=Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA. |journal=J. Biol. Chem. |volume=282 |issue= 33 |pages= 24444-54 |year= 2007 |pmid= 17580305 |doi= 10.1074/jbc.M702717200 }}
*{{cite journal | author=Wuertz K, Urban JP, Klasen J, ''et al.'' |title=Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells. |journal=J. Orthop. Res. |volume=25 |issue= 11 |pages= 1513-22 |year= 2007 |pmid= 17568421 |doi= 10.1002/jor.20436 }}
*{{cite journal | author=Xia X, Cui Y, Huang Y, ''et al.'' |title=A first familial G504S mutation of COL2A1 gene results in distinctive spondyloepiphyseal dysplasia congenita. |journal=Clin. Chim. Acta |volume=382 |issue= 1-2 |pages= 148-50 |year= 2007 |pmid= 17509551 |doi= 10.1016/j.cca.2007.04.005 }}
*{{cite journal | author=Richards AJ, Laidlaw M, Meredith SP, ''et al.'' |title=Missense and silent mutations in COL2A1 result in Stickler syndrome but via different molecular mechanisms. |journal=Hum. Mutat. |volume=28 |issue= 6 |pages= 639 |year= 2007 |pmid= 17437277 |doi= 10.1002/humu.9497 }}
*{{cite journal | author=Miyamoto Y, Matsuda T, Kitoh H, ''et al.'' |title=A recurrent mutation in type II collagen gene causes Legg-Calvé-Perthes disease in a Japanese family. |journal=Hum. Genet. |volume=121 |issue= 5 |pages= 625-9 |year= 2007 |pmid= 17394019 |doi= 10.1007/s00439-007-0354-y }}
*{{cite journal | author=Aigner T, Neureiter D, Câmpean V, ''et al.'' |title=Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions. |journal=Atherosclerosis |volume=196 |issue= 1 |pages= 37-41 |year= 2008 |pmid= 17335825 |doi= 10.1016/j.atherosclerosis.2007.01.020 }}
*{{cite journal | author=Valdes AM, Loughlin J, Oene MV, ''et al.'' |title=Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. |journal=Arthritis Rheum. |volume=56 |issue= 1 |pages= 137-46 |year= 2007 |pmid= 17195216 |doi= 10.1002/art.22301 }}
*{{cite journal | author=Walter K, Tansek M, Tobias ES, ''et al.'' |title=COL2A1-related skeletal dysplasias with predominant metaphyseal involvement. |journal=Am. J. Med. Genet. A |volume=143 |issue= 2 |pages= 161-7 |year= 2007 |pmid= 17163530 |doi= 10.1002/ajmg.a.31516 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HBA1... {April 10, 2008 4:26:11 PM PDT}
- REDIRECT: Protein Redirected to: HBA1 {April 10, 2008 4:26:23 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {April 10, 2008 4:26:26 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {April 10, 2008 4:26:26 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {April 10, 2008 4:26:26 PM PDT}
- UPDATED: Updated protein page: HBA1 {April 10, 2008 4:26:30 PM PDT}
- INFO: Beginning work on SMAD3... {April 10, 2008 4:26:31 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {April 10, 2008 4:27:03 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SMAD3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dev.
| PDB = {{PDB2|1dev}}, {{PDB2|1khx}}, {{PDB2|1mhd}}, {{PDB2|1mjs}}, {{PDB2|1mk2}}, {{PDB2|1ozj}}, {{PDB2|1u7f}}, {{PDB2|1u7v}}
| Name = SMAD family member 3
| HGNCid = 6769
| Symbol = SMAD3
| AltSymbols =; DKFZP586N0721; DKFZp686J10186; HSPC193; HsT17436; JV15-2; MADH3; MGC60396; Smad 3
| OMIM = 603109
| ECnumber =
| Homologene = 55937
| MGIid = 1201674
| GeneAtlas_image1 = PBB_GE_SMAD3_205396_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMAD3_205397_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMAD3_205398_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}}{{GNF_GO|id=GO:0003700 |text = transcription factor activity}}{{GNF_GO|id=GO:0008134 |text = transcription factor binding}}{{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016202 |text = regulation of striated muscle development}} {{GNF_GO|id=GO:0017015 |text = regulation of transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048340 |text = paraxial mesoderm morphogenesis}} {{GNF_GO|id=GO:0050678 |text = regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050776 |text = regulation of immune response}} {{GNF_GO|id=GO:0051098 |text = regulation of binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4088
| Hs_Ensembl = ENSG00000166949
| Hs_RefseqProtein = NP_005893
| Hs_RefseqmRNA = NM_005902
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 65145249
| Hs_GenLoc_end = 65274586
| Hs_Uniprot = P84022
| Mm_EntrezGene = 17127
| Mm_Ensembl = ENSMUSG00000032402
| Mm_RefseqmRNA = NM_016769
| Mm_RefseqProtein = NP_058049
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 63444773
| Mm_GenLoc_end = 63556000
| Mm_Uniprot = Q3V3E0
}}
}}
'''SMAD family member 3''', also known as '''SMAD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMAD3 SMAD family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4088| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li H, Liu JP |title=Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene. |journal=Ann. N. Y. Acad. Sci. |volume=1114 |issue= |pages= 56-68 |year= 2008 |pmid= 17934056 |doi= 10.1196/annals.1396.016 }}
*{{cite journal | author=Matsuzaki K |title=Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. |journal=Histol. Histopathol. |volume=21 |issue= 6 |pages= 645-62 |year= 2006 |pmid= 16528675 |doi= }}
*{{cite journal | author=Miyazono K |title=TGF-beta signaling by Smad proteins. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 15-22 |year= 2000 |pmid= 10708949 |doi= }}
*{{cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5-13 |year= 2000 |pmid= 10708948 |doi= }}
*{{cite journal | author=Verschueren K, Huylebroeck D |title=Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 187-99 |year= 2000 |pmid= 10647776 |doi= }}
*{{cite journal | author=Massagué J |title=TGF-beta signal transduction. |journal=Annu. Rev. Biochem. |volume=67 |issue= |pages= 753-91 |year= 1998 |pmid= 9759503 |doi= 10.1146/annurev.biochem.67.1.753 }}
*{{cite journal | author=Walker LC, Waddell N, Ten Haaf A, ''et al.'' |title=Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. |journal= |volume= |issue= |pages= |year= |pmid= 18095154 |doi= 10.1007/s10549-007-9848-5 }}
*{{cite journal | author=Lee KB, Jeon JH, Choi I, ''et al.'' |title=Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability. |journal=Biochem. Biophys. Res. Commun. |volume=366 |issue= 4 |pages= 905-9 |year= 2008 |pmid= 18082619 |doi= 10.1016/j.bbrc.2007.12.033 }}
*{{cite journal | author=Kim TD, Shin S, Janknecht R |title=Repression of Smad3 activity by histone demethylase SMCX/JARID1C. |journal=Biochem. Biophys. Res. Commun. |volume=366 |issue= 2 |pages= 563-7 |year= 2008 |pmid= 18078810 |doi= 10.1016/j.bbrc.2007.12.013 }}
*{{cite journal | author=Zhao X, Nicholls JM, Chen YG |title=Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=283 |issue= 6 |pages= 3272-80 |year= 2008 |pmid= 18055455 |doi= 10.1074/jbc.M708033200 }}
*{{cite journal | author=Li T, Chiang JY |title=A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. |journal=Gastroenterology |volume=133 |issue= 5 |pages= 1660-9 |year= 2007 |pmid= 17920062 |doi= 10.1053/j.gastro.2007.08.042 }}
*{{cite journal | author=Lu S, Lee J, Revelo M, ''et al.'' |title=Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. |journal=Clin. Cancer Res. |volume=13 |issue= 19 |pages= 5692-702 |year= 2007 |pmid= 17908958 |doi= 10.1158/1078-0432.CCR-07-1078 }}
*{{cite journal | author=Kalo E, Buganim Y, Shapira KE, ''et al.'' |title=Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. |journal=Mol. Cell. Biol. |volume=27 |issue= 23 |pages= 8228-42 |year= 2007 |pmid= 17875924 |doi= 10.1128/MCB.00374-07 }}
*{{cite journal | author=Weng HL, Ciuclan L, Liu Y, ''et al.'' |title=Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. |journal=Hepatology |volume=46 |issue= 4 |pages= 1257-70 |year= 2007 |pmid= 17657819 |doi= 10.1002/hep.21806 }}
*{{cite journal | author=Dennler S, André J, Alexaki I, ''et al.'' |title=Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. |journal=Cancer Res. |volume=67 |issue= 14 |pages= 6981-6 |year= 2007 |pmid= 17638910 |doi= 10.1158/0008-5472.CAN-07-0491 }}
*{{cite journal | author=Zhang M, Lee CH, Luo DD, ''et al.'' |title=Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. |journal=J. Biol. Chem. |volume=282 |issue= 39 |pages= 28639-47 |year= 2007 |pmid= 17623674 |doi= 10.1074/jbc.M700594200 }}
*{{cite journal | author=Martin MM, Buckenberger JA, Jiang J, ''et al.'' |title=TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=293 |issue= 3 |pages= L790-9 |year= 2007 |pmid= 17601799 |doi= 10.1152/ajplung.00099.2007 }}
*{{cite journal | author=Dai F, Chang C, Lin X, ''et al.'' |title=Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. |journal=Mol. Cell. Biol. |volume=27 |issue= 17 |pages= 6183-94 |year= 2007 |pmid= 17591701 |doi= 10.1128/MCB.00132-07 }}
*{{cite journal | author=Levy L, Howell M, Das D, ''et al.'' |title=Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. |journal=Mol. Cell. Biol. |volume=27 |issue= 17 |pages= 6068-83 |year= 2007 |pmid= 17591695 |doi= 10.1128/MCB.00664-07 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMAD4... {April 10, 2008 4:27:03 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {April 10, 2008 4:27:24 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SMAD4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dd1.
| PDB = {{PDB2|1dd1}}, {{PDB2|1g88}}, {{PDB2|1mr1}}, {{PDB2|1u7f}}, {{PDB2|1u7v}}, {{PDB2|1ygs}}
| Name = SMAD family member 4
| HGNCid = 6770
| Symbol = SMAD4
| AltSymbols =; DPC4; JIP; MADH4
| OMIM = 600993
| ECnumber =
| Homologene = 31310
| MGIid = 894293
| GeneAtlas_image1 = PBB_GE_SMAD4_202527_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMAD4_202526_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}{{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}}{{GNF_GO|id=GO:0005515 |text = protein binding}}{{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0001822 |text = kidney development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007183 |text = SMAD protein complex assembly}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0010003 |text = gastrulation (sensu Mammalia)}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0051098 |text = regulation of binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4089
| Hs_Ensembl = ENSG00000141646
| Hs_RefseqProtein = NP_005350
| Hs_RefseqmRNA = NM_005359
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 46810611
| Hs_GenLoc_end = 46860142
| Hs_Uniprot = Q13485
| Mm_EntrezGene = 17128
| Mm_Ensembl = ENSMUSG00000024515
| Mm_RefseqmRNA = XM_001001632
| Mm_RefseqProtein = XP_001001632
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 73764378
| Mm_GenLoc_end = 73829110
| Mm_Uniprot = Q6GTP6
}}
}}
'''SMAD family member 4''', also known as '''SMAD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMAD4 SMAD family member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4089| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miyazono K |title=TGF-beta signaling by Smad proteins. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 15-22 |year= 2000 |pmid= 10708949 |doi= }}
*{{cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5-13 |year= 2000 |pmid= 10708948 |doi= }}
*{{cite journal | author=Verschueren K, Huylebroeck D |title=Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 187-99 |year= 2000 |pmid= 10647776 |doi= }}
*{{cite journal | author=Massagué J |title=TGF-beta signal transduction. |journal=Annu. Rev. Biochem. |volume=67 |issue= |pages= 753-91 |year= 1998 |pmid= 9759503 |doi= 10.1146/annurev.biochem.67.1.753 }}
*{{cite journal | author=Klein-Scory S, Zapatka M, Eilert-Micus C, ''et al.'' |title=High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. |journal=BMC Cancer |volume=7 |issue= |pages= 209 |year= 2008 |pmid= 17997817 |doi= 10.1186/1471-2407-7-209 }}
*{{cite journal | author=Kalo E, Buganim Y, Shapira KE, ''et al.'' |title=Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. |journal=Mol. Cell. Biol. |volume=27 |issue= 23 |pages= 8228-42 |year= 2007 |pmid= 17875924 |doi= 10.1128/MCB.00374-07 }}
*{{cite journal | author=Aretz S, Stienen D, Uhlhaas S, ''et al.'' |title=High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome. |journal=J. Med. Genet. |volume=44 |issue= 11 |pages= 702-9 |year= 2007 |pmid= 17873119 |doi= 10.1136/jmg.2007.052506 }}
*{{cite journal | author=Ali S, Cohen C, Little JV, ''et al.'' |title=The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors. |journal=Diagn. Cytopathol. |volume=35 |issue= 10 |pages= 644-8 |year= 2007 |pmid= 17854080 |doi= 10.1002/dc.20715 }}
*{{cite journal | author=Milet J, Dehais V, Bourgain C, ''et al.'' |title=Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance. |journal=Am. J. Hum. Genet. |volume=81 |issue= 4 |pages= 799-807 |year= 2007 |pmid= 17847004 |doi= 10.1086/520001 }}
*{{cite journal | author=Salek C, Benesova L, Zavoral M, ''et al.'' |title=Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. |journal=World J. Gastroenterol. |volume=13 |issue= 27 |pages= 3714-20 |year= 2007 |pmid= 17659731 |doi= }}
*{{cite journal | author=Sebestyén A, Hajdu M, Kis L, ''et al.'' |title=Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells. |journal=Exp. Cell Res. |volume=313 |issue= 15 |pages= 3167-74 |year= 2007 |pmid= 17643425 |doi= 10.1016/j.yexcr.2007.05.028 }}
*{{cite journal | author=Martin MM, Buckenberger JA, Jiang J, ''et al.'' |title=TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=293 |issue= 3 |pages= L790-9 |year= 2007 |pmid= 17601799 |doi= 10.1152/ajplung.00099.2007 }}
*{{cite journal | author=Levy L, Howell M, Das D, ''et al.'' |title=Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. |journal=Mol. Cell. Biol. |volume=27 |issue= 17 |pages= 6068-83 |year= 2007 |pmid= 17591695 |doi= 10.1128/MCB.00664-07 }}
*{{cite journal | author=Grijelmo C, Rodrigue C, Svrcek M, ''et al.'' |title=Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. |journal=Cell. Signal. |volume=19 |issue= 8 |pages= 1722-32 |year= 2007 |pmid= 17478078 |doi= 10.1016/j.cellsig.2007.03.008 }}
*{{cite journal | author=Sonegawa H, Nukui T, Li DW, ''et al.'' |title=Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression. |journal=J. Mol. Med. |volume=85 |issue= 7 |pages= 753-62 |year= 2007 |pmid= 17476473 |doi= 10.1007/s00109-007-0180-7 }}
*{{cite journal | author=Sheikh AA, Vimalachandran D, Thompson CC, ''et al.'' |title=The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. |journal=Proteomics |volume=7 |issue= 11 |pages= 1929-40 |year= 2007 |pmid= 17469085 |doi= 10.1002/pmic.200700072 }}
*{{cite journal | author=Popović Hadzija M, Korolija M, Jakić Razumović J, ''et al.'' |title=K-ras and Dpc4 mutations in chronic pancreatitis: case series. |journal=Croat. Med. J. |volume=48 |issue= 2 |pages= 218-24 |year= 2007 |pmid= 17436386 |doi= }}
*{{cite journal | author=Losi L, Bouzourene H, Benhattar J |title=Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. |journal=Oncol. Rep. |volume=17 |issue= 5 |pages= 1095-9 |year= 2007 |pmid= 17390050 |doi= }}
*{{cite journal | author=Karlsson G, Blank U, Moody JL, ''et al.'' |title=Smad4 is critical for self-renewal of hematopoietic stem cells. |journal=J. Exp. Med. |volume=204 |issue= 3 |pages= 467-74 |year= 2007 |pmid= 17353364 |doi= 10.1084/jem.20060465 }}
*{{cite journal | author=Takano S, Kanai F, Jazag A, ''et al.'' |title=Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1. |journal=J. Biochem. |volume=141 |issue= 3 |pages= 345-51 |year= 2007 |pmid= 17301079 |doi= 10.1093/jb/mvm039 }}
}}
{{refend}}
{{protein-stub}}
end log.
