User:Mr. Ibrahem/Zanamivir

Mr. Ibrahem/Zanamivir
Clinical data
Pronunciation	/zəˈnæmɪvɪər/
Trade names	Relenza, Dectova, others
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: B1; ;
Routes of; administration	Inhalation, IV
Drug class	Neuraminidase inhibitor
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	2% (by mouth)
Protein binding	<10%
Metabolism	Negligible
Elimination half-life	2.5–5.1 hours
Excretion	Kidney
Identifiers
	IUPAC name (2R,3R,4S)-4-guanidino-3-(prop-1-en-2-ylamino)-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid;
Chemical and physical data
Formula	C12H20N4O7
Molar mass	332.313 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C=1O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](/N=C(\N)N)C=1;
	InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 ; Key:ARAIBEBZBOPLMB-UFGQHTETSA-N ;
	(verify)

Zanamivir, sold under the brand name Relenza among others, is a medication used to treat and prevent influenza due to influenza A or B viruses.^[1] It is used by breathing in the powder or by injection into a vein.^[1]^[3]

Common side effects include headache, dizziness, bronchitis, and cough.^[1] Use is not recommended in those with asthma or COPD.^[1] While it does not appear to cause harm in pregnancy or breastfeeding, it has not been well studied in this population.^[4] It is a neuraminidase inhibitor and works by stopping viral replication.^[1]

Zanamivir was approved for medical use in the United States in 1999.^[1] One course of treatment in the United States costs about 68 USD as of 2021.^[5] This amount in the United Kingdom costs the NHS about £16.^[2] The injectable form is available in Europe.^[3]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Zanamivir Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 4 August 2021.
^ ^a ^b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 700. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b "Dectova". Archived from the original on 2 January 2021. Retrieved 4 August 2021.
^ "Zanamivir (Relenza) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 4 August 2021.
^ "Zanamivir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 June 2016. Retrieved 4 August 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Zanamivir Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 4 August 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 700. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EMA2021-3] "Dectova". Archived from the original on 2 January 2021. Retrieved 4 August 2021.

[Preg2021-4] "Zanamivir (Relenza) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 4 August 2021.

[5] "Zanamivir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 June 2016. Retrieved 4 August 2021.

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