 (1S,2R)-(−)-tranylcypromine (top), (1R,2S)-(+)-tranylcypromine (bottom) | |
| Clinical data | |
|---|---|
| Trade names | Parnate, others[1] |
| Other names | trans-2-phenylcyclopropylamine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682088 |
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Monoamine oxidase inhibitor (MAOI)[2] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 50%[3] |
| Metabolism | Liver[4][5] |
| Onset of action | Up to 3 weeks[2] |
| Elimination half-life | 2.5 hours[3] |
| Excretion | Urine, feces[3] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C9H11N |
| Molar mass | 133.194 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
  (what is this?) (verify) | |
Tranylcypromine, sold under the trade name Parnate among others, is a medication used to treat major depressive disorder.[2] It; however, is not used as a first line treatment.[2] It is taken by mouth.[2] Onset of effects may require up to 3 weeks.[2]
Common side effects may include trouble sleeping, nausea, dry mouth, fast heart rate, and sexual dysfunction.[2] Other side effect may include high blood pressure, mania, serotonin syndrome, and an increased risk of suicide in those under the age of 25.[2] It is a monoamine oxidase inhibitor (MAOI) and believed to work by increasing serotonin and norepinephrine.[2]
Tranylcypromine was approved for medical use in the United States in 1961.[2] It is available as a generic medication.[6] In the United Kingdom it costs the NHS about £370 at 10 mg per day for a month as of 2021.[6] This amount in the United States costs about 22 USD.[7]
References edit
- ^ "Tranylcypromine Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 29 August 2017. Retrieved 16 September 2021.
- ^ a b c d e f g h i j k l "Tranylcypromine Monograph for Professionals". Drugs.com. Archived from the original on 20 January 2021. Retrieved 16 September 2021.
- ^ a b c Williams DA (2007). "Antidepressants". In Foye, William O., Lemke, Thomas L., Williams, David A. (eds.). Foye's Principles of Medicinal Chemistry. Hagerstwon, USA: Lippincott Williams & Wilkins. pp. 590–1. ISBN 978-0-7817-6879-5. Archived from the original on 2021-08-29. Retrieved 2021-05-30.
- ^ "Tranylcypromine". www.drugbank.ca. Archived from the original on 2019-10-23. Retrieved 2019-12-06.
- ^ Baker GB, Urichuk LJ, McKenna KF, Kennedy SH (June 1999). "Metabolism of monoamine oxidase inhibitors". Cellular and Molecular Neurobiology. 19 (3): 411–26. doi:10.1023/a:1006901900106. PMID 10319194. S2CID 21380176.
- ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 380. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Tranylcypromine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 September 2021.