User:Mr. Ibrahem/Tiotixene

Mr. Ibrahem/Tiotixene

Clinical data
Trade names	Navane, others
Other names	Thiothixene, Thiothixene (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a682867
Pregnancy category	AU: B1
Routes of administration	By mouth
Drug class	Typical antipsychotic
Legal status
Legal status	AU: S4 (Prescription only) In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	Liver
Onset of action	Within 4 weeks
Elimination half-life	10–20 hours
Identifiers
IUPAC name (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Chemical and physical data
Formula	C23H29N3O2S2
Molar mass	443.62 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4
InChI InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- Y Key:GFBKORZTTCHDGY-UWVJOHFNSA-N Y
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Tiotixene, also known as thiothixene and sold under the brand name Navane among others, is a typical antipsychotic used to treat psychoses such as schizophrenia. It is not useful for behavioral problems in intellectual disability. It is taken by mouth. Benefits generally begin within 4 weeks but maximal effect may take up to 6 months.

Common side effects include sleepiness, movement disorders, dry mouth, low blood pressure, and blurry vision. Other side effects include an increased risk of death in those with dementia, neuroleptic malignant syndrome, and allergic reactions. It is in the thioxanthene family of chemicals and believed to work by inhibiting dopamine.

Tiotixene was approved for medical use in the United States in 1967. In the United States 30 pills of 10 mg costs about 30 USD.