 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Aubagio |
| Other names | A77 1726 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a613010 |
| License data |
|
| Pregnancy category | |
| Routes of administration | By mouth |
| Drug class | Pyrimidine synthesis inhibitor[2] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | >99.3% |
| Elimination half-life | 2 weeks |
| Excretion | Bile duct/fecal, kidney |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H9F3N2O2 |
| Molar mass | 270.211 g·mol−1 |
| 3D model (JSmol) | |
| |
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Teriflunomide, sold under the brand name Aubagio, is a medication used to treat multiple sclerosis (MS); specifically relapsing-remitting MS.[3][4] In Scotland it is used as a second line treatment to interferon beta and glatiramer.[2] It is taken by mouth.[3]
Common side effects include headache, diarrhea, liver problems, nausea, and hair loss.[4] Other side effects may include liver failure, peripheral neuropathy, and interstitial lung disease.[3] Use in the two years before or during pregnancy may harm the baby.[2] It is a pyrimidine synthesis inhibitor.[2] While how it works is not entirely clear, it is believed to decrease the number of lymphocytes.[4] It is the active metabolite of leflunomide.[3]
Teriflunomide was approved for medical use in the United States in 2012 and and Europe 2013.[4][3] In the United Kingdom it costs the NHS about 1,100 pounds per month.[2] This amount in the United States costs about 8,400 USD as of 2021.[5]
References edit
- ^ a b c "Teriflunomide (Aubagio) Use During Pregnancy". Drugs.com. 11 September 2019. Archived from the original on 2 March 2020. Retrieved 2 March 2020.
- ^ a b c d e f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 905. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ a b c d e f "Teriflunomide Monograph for Professionals". Drugs.com. Archived from the original on 2 March 2020. Retrieved 29 September 2021.
- ^ a b c d e "Aubagio EPAR". European Medicines Agency (EMA). 26 February 2020. Archived from the original on 29 December 2019. Retrieved 1 March 2020.
- ^ "Aubagio Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 6 August 2020. Retrieved 29 September 2021.