User:Mr. Ibrahem/Sulindac

Mr. Ibrahem/Sulindac
Clinical data
Trade names	Clinoril, others
AHFS/Drugs.com	Monograph
MedlinePlus	a681037
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	Approximately 90% (Oral)
Metabolism	?
Onset of action	1 hr
Elimination half-life	7.8 hours, metabolites up to 16.4 hours
Duration of action	Up to 16 hr
Excretion	Kidney (50%) and fecal (25%)
Identifiers
	IUPAC name {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-indene-3-yl}acetic acid;
Chemical and physical data
Formula	C20H17FO3S
Molar mass	356.41 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	182 to 185 °C (360 to 365 °F) (decomp.)
	SMILES O=S(c1ccc(cc1)\C=C3/c2ccc(F)cc2\C(=C3C)CC(=O)O)C;
	InChI InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- ; Key:MLKXDPUZXIRXEP-MFOYZWKCSA-N ;
	(what is this?) (verify)

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation.^[3] This includes in conditions like attacks of gout, osteoarthritis, and rheumatoid arthritis.^[2] It is taken by mouth.^[2] Effects begin in about an hour and last for up to 16 hours.^[1]

Common side effects may include nausea, diarrhea, rash, headache, and an upset stomach.^[3] Other side effects may include liver problems, pancreatitis, allergic reactions, kidney problems, stomach bleeding, and heart failure.^[3] It should not be used in the later half of pregnancy.^[3] It works by blocking COX-1 and COX-2.^[3]

Sulindac was patented in 1969 and approved for medical use in 1976.^[4] It is available as a generic medication.^[2] In the United Kingdom 56 tablets of 200 mg costs the NHS about £40.^[2] In the United States this amount costs about 15 USD.^[5]

References edit

^ ^a ^b ^c Aschenbrenner, Diane S.; Venable, Samantha J. (2009). Drug Therapy in Nursing. Lippincott Williams & Wilkins. p. 411. ISBN 978-0-7817-6587-9. Archived from the original on 2021-10-15. Retrieved 2021-10-15.
^ ^a ^b ^c ^d ^e ^f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1213. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b ^c ^d ^e ^f "Sulindac Monograph for Professionals". Drugs.com. Archived from the original on 30 September 2020. Retrieved 15 October 2021.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. Archived from the original on 2021-07-26. Retrieved 2020-10-17.
^ "Sulindac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 15 October 2021.

[Dia2009-1] Aschenbrenner, Diane S.; Venable, Samantha J. (2009). Drug Therapy in Nursing. Lippincott Williams & Wilkins. p. 411. ISBN 978-0-7817-6587-9. Archived from the original on 2021-10-15. Retrieved 2021-10-15.

[BNF80-2] ^ ^a ^b ^c ^d ^e ^f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1213. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-3] ^ ^a ^b ^c ^d ^e ^f "Sulindac Monograph for Professionals". Drugs.com. Archived from the original on 30 September 2020. Retrieved 15 October 2021.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. Archived from the original on 2021-07-26. Retrieved 2020-10-17.

[5] "Sulindac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 15 October 2021.

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