 | |
| Clinical data | |
|---|---|
| Trade names | Gas-X, Infacol, Wind-eze, others |
| Other names | Activated dimeticone, simethicone[1] (USAN US) |
| AHFS/Drugs.com | Monograph |
| Routes of administration | By mouth |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | None |
| Protein binding | 0% |
| Metabolism | Not metabolized |
| Elimination half-life | N/A |
| Excretion | feces |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | (C2H6OSi)n · (SiO2)m |
| Molar mass | variable |
  (what is this?) (verify) | |
Simeticone, also spelled simethicone, is a medication used to treat excess intestinal gas.[2] Evidence of benefit is; however, unclear.[3] It is taken by mouth.[2] It is not recommended for baby colic in the United States but is used for this purpose in the United Kingdom.[2][4]
It is generally well tolerated.[2] Use during breastfeeding and pregnancy is believed to be safe.[2][5] It acts within the intestines and is said to works by promoting the breakdown of bubbles.[2]
Simeticone has been in medical use since the 1950s.[6] It is available as a generic medication and over the counter.[2] It is relatively inexpensive.[7] It may also be available in combination with other medications such as loperamide and antacids.[4]
References edit
- ^ "Simethicone names". Drugs.com. Archived from the original on 18 September 2018. Retrieved 27 August 2017.
- ^ a b c d e f g "Simethicone Monograph for Professionals". Drugs.com. Archived from the original on 26 June 2018. Retrieved 7 October 2020.
- ^ Modi, Ronak; Clearfield, Harris R.; Levitt, Michael (July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology. Archived from the original on 2018-07-28. Retrieved 2017-08-27.
- ^ a b BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 68, 72. ISBN 9780857113658.
- ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 1334. ISBN 978-1-4511-5359-0. Archived from the original on 2021-08-29. Retrieved 2020-10-07.
- ^ Chandrasekhara, Vinay; Elmunzer, B. Joseph; Khashab, Mouen; Muthusamy, V. Raman (2018). Clinical Gastrointestinal Endoscopy E-Book. Elsevier Health Sciences. p. 351. ISBN 978-0-323-54792-5. Archived from the original on 2021-08-29. Retrieved 2020-10-07.
- ^ Kellerman, Rick D.; Association, KUSM-W. Medical Practice (2020). Conn's Current Therapy 2020, E-Book. Elsevier Health Sciences. p. 58. ISBN 978-0-323-73299-4. Archived from the original on 2021-08-29. Retrieved 2020-10-07.