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User:Mr. Ibrahem/Risedronic acid

< User:Mr. Ibrahem
Mr. Ibrahem/Risedronic acid
Clinical data
Trade namesActonel, Atelvia, Benet, others
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Drug classBisphosphonate[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability0.63%
Protein binding~24%
MetabolismNone
Elimination half-life1.5 h
ExcretionKidney and fecal
Identifiers
  • (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid
Chemical and physical data
FormulaC7H11NO7P2
Molar mass283.112 g·mol−1
3D model (JSmol)
  • OC(Cc1cccnc1)(P(=O)(O)O)P(=O)(O)O
  • InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) ☒N
  • Key:IIDJRNMFWXDHID-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Risedronic acid, often used as its salt risedronate sodium, is a bisphosphonate used to treat and prevent osteoporosis or to treat Paget's disease of bone.[1] It is taken by mouth.[1]

Common side effects include constipation, nausea, headache, and rash.[1] Other side effects may include esophageal inflammation, esophageal perforation, osteonecrosis of the jaw, low calcium, and muscle pain.[1] Use is not recommended in those with significant kidney problems.[2] It works by inhibiting the cells which break down bone.[1]

Risedronic acid was patented in 1984 and approved for medical use in 1998.[3] It is available as a generic medication.[4] In the United States it costs about 30 USD per month as of 2021.[4] In the United Kingdom it costs the NHS about £10 per month.[2]

References edit

  1. ^ a b c d e f g "Risedronate Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 19 July 2021.
  2. ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 770. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 9783527607495. Archived from the original on 2021-03-18. Retrieved 2020-08-27.
  4. ^ a b "Risedronate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 July 2021.
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