 A bottle of Ringer's lactate solution | |
| Clinical data | |
|---|---|
| Other names | Compound sodium lactate, sodium lactate solution, Hartmann's solution, Ringer-Locke's solution, Ringer-lactate, lactated Ringer's solution (LRS) |
| AHFS/Drugs.com | FDA Professional Drug Information |
| License data | |
| Routes of administration | intravenous, topical, subcutaneous |
| Pharmacokinetic data | |
| Duration of action | 1 to 2 hours[1] |
Ringer's lactate solution (RL), also known as sodium lactate solution and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water.[3] It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure.[4] It may also be used to treat metabolic acidosis and to wash the eye following a chemical burn.[4][5] It is given by injection into a vein or applied to the affected area.[4][5]
Side effects may include allergic reactions, high blood potassium, volume overload, and high blood calcium.[4] It may not be suitable for mixing with certain medications and some recommend against use in the same infusion as a blood transfusion.[6] Ringer's lactate solution has a lower rate of acidosis as compared with normal saline.[3][6] Use is generally safe in pregnancy and breastfeeding.[4] Ringer's lactate solution is in the crystalloid family of medication.[7] It has the same tonicity as blood.[4]
Ringer's solution was invented in the 1880s with lactate being added in the 1930s.[6] It is on the World Health Organization's List of Essential Medicines.[8] Lactated Ringer's is available as a generic medication.[3] The wholesale cost in the developing world is about US$0.60 to US$2.30 per liter.[9] For people with poor liver function, Ringer's acetate may be a better alternative with the lactate replaced by acetate.[10] In Scandinavia Ringer's acetate is typically used.[11]
References edit
- ^ a b "Volume expanders - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 4 September 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 13 September 2020.
- ^ a b c British national formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 683. ISBN 9780857111562.
- ^ a b c d e f "Compound Sodium Lactate Solution for Infusion - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. February 2013. Archived from the original on 16 January 2017. Retrieved 14 January 2017.
- ^ a b Krieglstein, G. K. (2000). Atlas of Ophthalmology. Springer Science & Business Media. p. 377. ISBN 9783540780694. Archived from the original on 2017-01-16.
- ^ a b c Marino, Paul L.; Sutin, Kenneth M. (2012). The ICU Book (3 ed.). Lippincott Williams & Wilkins. p. 363. ISBN 9781451161557. Archived from the original on 2017-09-18.
- ^ Saade, George R.; Foley, Michael R.; Phelan, Jeffrey P.; III, Gary A. Dildy (2010). Critical Care Obstetrics. John Wiley & Sons. p. 70. ISBN 9781444396140. Archived from the original on 2017-01-16.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Sodium Lactate Compound". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
- ^ Marino, Paul L. (2013). Marino's The ICU Book (4 ed.). Lippincott Williams & Wilkins. p. 223. ISBN 9781469831640. Archived from the original on 2017-01-16.
- ^ Bjarby, Johan. "Vätsketerapi för AT/ST läkare KSS — 'Rehydration therapy for interns and specialists, KSS'" (PDF). Västragötalandsregionen. Archived (PDF) from the original on 16 January 2017. Retrieved 13 January 2017.