 | |
| Clinical data | |
|---|---|
| Trade names | Ultiva, others |
| Other names | methyl 1-(2-methoxycarbonylethyl)-4-(phenyl-propanoyl-amino)-piperidine-4-carboxylate |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
|
| Routes of administration | Intravenous |
| Drug class | Opioid[1] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | Not applicable (intravenous administration) |
| Protein binding | 70% (bound to plasma proteins) |
| Metabolism | cleaved by non-specific plasma and tissue esterases |
| Onset of action | Within 90 sec[1] |
| Elimination half-life | 1-20 minutes |
| Duration of action | Up to 15 minutes[1] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C20H28N2O5 |
| Molar mass | 376.453 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 5 °C (41 °F) |
| |
| |
| (verify) | |
Remifentanil, sold under the brand name Ultiva among others, is an opioid medication used to treat during anesthesia to manage pain.[1] It is given by injection into a vein.[1] Effects begin within 90 seconds and last up to 15 minutes.[1]
Common side effects include respiratory depression (decreased breathing), slow heart rate, low blood pressure, stiff muscles, nausea, and itchiness.[1] Breastfeeding is not recommended for 24 hours after use.[2] It works by activating the mu opioid receptor.[1]
Remifentanil was approved for medical use in the United States in 1996.[1] It is available as a generic medication.[2] In the United Kingdom 1 mg costs the NHS about £5 as of 2021.[1] In the United States this amount costs about 55 USD.[3] In the United States it is classified as a Schedule II controlled substance.[1]
References edit
- ^ a b c d e f g h i j k l m "Remifentanil Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 16 October 2021.
- ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1415. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Remifentanil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 16 October 2021.