Clinical data | |
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Trade names | Nuplazid |
Other names | ACP-103; BVF-048 |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth (tablets) |
Drug class | Atypical antipsychotic |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 94–97%[1] |
Metabolism | Liver (CYP3A4, CYP3A5, CYP2J2)[2] |
Elimination half-life | 54–56 hours[1] |
Identifiers | |
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Chemical and physical data | |
Formula | C25H34FN3O2 |
Molar mass | 427.564 g·mol−1 |
3D model (JSmol) | |
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Pimavanserin, sold under the brand name Nuplazid, is an medication used to treat psychosis in Parkinson's disease.[3] It is not recommended for psychosis due to dementia.[3] It is taken by mouth.[3]
Common side effects include swelling and confusion.[4] Other side effects may include QT prolongation.[4] Use in not recommended in those with liver problems.[3] It is an atypical antipsychotic.[3] How it works is not clear but may involved effects on serotonin receptors.[3]
Pimavanserin was approved for medical use in the United States in 2016.[3] It is not approved in Europe or the United Kingdom as of 2021.[5] In the United States it costs about 4,200 USD per month as of 2021.[6]
References edit
- ^ a b Friedman JH (October 2013). "Pimavanserin for the treatment of Parkinson's disease psychosis". Expert Opinion on Pharmacotherapy. 14 (14): 1969–75. doi:10.1517/14656566.2013.819345. PMID 24016069. S2CID 35649566.
- ^ "Nuplazid (pimavanserin) Tablets, for Oral Use. U.S. Full Prescribing Information" (PDF). ACADIA Pharmaceuticals Inc. Archived from the original (PDF) on 3 October 2018. Retrieved 5 Nov 2018.
- ^ a b c d e f g h i "Pimavanserin Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 28 October 2021.
- ^ a b c "DailyMed - NUPLAZID- pimavanserin tartrate capsule NUPLAZID- pimavanserin tartrate tablet, coated". dailymed.nlm.nih.gov. Archived from the original on 4 May 2021. Retrieved 28 October 2021.
- ^ "Pimavanserin". SPS - Specialist Pharmacy Service. 1 January 2016. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
- ^ "Nuplazid Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 28 October 2021.