User:Mr. Ibrahem/Perphenazine

Mr. Ibrahem/Perphenazine
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a682165
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth and IM
Drug class	Typical antipsychotic
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	40%
Metabolism	Liver
Elimination half-life	8-12 (up to 20) hours
Identifiers
	IUPAC name 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl) propyl]piperazin-1-yl]ethanol;
Chemical and physical data
Formula	C21H26ClN3OS
Molar mass	403.97 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4;
	InChI InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2 ; Key:RGCVKNLCSQQDEP-UHFFFAOYSA-N ;
	(verify)

Perphenazine, sold under the brand name Trilafon among others, is a medication used to treat psychosis including in schizophrenia, anxiety, and nausea.^[1] Benefits appear similar to other antipsychotics.^[2] Use for behavioral problems in people with intellectual disability has not be proven useful.^[1] It is taken by mouth.^[1]

Common side effects include parkinsonism, which may include tardive dyskinesia, sleepiness, dry mouth, blurry vision, weight gain, and milk production.^[1] Other side effects may include an increased risk of death in the elderly with dementia, neuroleptic malignant syndrome, low blood pressure, seizures, and anaphylaxis.^[1] Use in pregnancy may harm the baby.^[3] It is a typical antipsychotic of the phenothiazine class.^[1]

Perphenazine was approved for medical use in the United States in 1957.^[1] In the United States 90 tablets of 4 mg costs about 33 USD as of 2021.^[4]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Perphenazine Monograph for Professionals". Drugs.com. Archived from the original on 14 April 2021. Retrieved 27 October 2021.
^ Hartung B, Sampson S, Leucht S (March 2015). "Perphenazine for schizophrenia". The Cochrane Database of Systematic Reviews. 3 (3): CD003443. doi:10.1002/14651858.CD003443.pub3. PMC 7173727. PMID 25749632.
^ "Perphenazine (Trilafon) Use During Pregnancy". Drugs.com. Archived from the original on 30 November 2020. Retrieved 27 October 2021.
^ "Perphenazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 31 October 2016. Retrieved 27 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Perphenazine Monograph for Professionals". Drugs.com. Archived from the original on 14 April 2021. Retrieved 27 October 2021.

[Har2015-2] Hartung B, Sampson S, Leucht S (March 2015). "Perphenazine for schizophrenia". The Cochrane Database of Systematic Reviews. 3 (3): CD003443. doi:10.1002/14651858.CD003443.pub3. PMC 7173727. PMID 25749632.

[Preg2021-3] "Perphenazine (Trilafon) Use During Pregnancy". Drugs.com. Archived from the original on 30 November 2020. Retrieved 27 October 2021.

[4] "Perphenazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 31 October 2016. Retrieved 27 October 2021.

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