 | |
| Clinical data | |
|---|---|
| Trade names | Afrin, Ocuclear, Drixine, others |
| Other names | Oxymetazoline hydrochloride |
| AHFS/Drugs.com | General: Monograph Topical: Monograph |
| Pregnancy category |
|
| Dependence liability | Moderate |
| Routes of administration | Intranasal, eye drops |
| Drug class | Alpha adrenergic agonist[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | Kidney (30%), fecal (10%) |
| Onset of action | Within 10 min[1] |
| Elimination half-life | 5–6 hours |
| Duration of action | 6 hrs[1] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C16H24N2O |
| Molar mass | 260.381 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 301.5 °C (574.7 °F) |
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Oxymetazoline, sold under many brand name, is a medication used to treat a stuffy nose or eye redness due to minor irritation.[1] It is available as a nasal spray or eye drops.[1] Benefits are seen within 10 minutes and last for up to 6 hours.[1] No more than 3 to 5 days of use is recommended; with use recommended against in those under 6 years.[2][3]
Common side effects may include burning and nasal discharge.[1] Other side effects may include recurrence of stuffiness following stopping use, headache, palpitations, and nervousness.[1] Safety in pregnancy is unclear.[1] It works by activating alpha adrenergic receptor which cases small arteries to narrow.[1]
Oxymetazoline was first made in 1961 and was approved for medical use in the United States in 1986.[2][1] It is available as a generic medication and over the counter.[1] In the United States 30 ml of solution costs about 12 USD as of 2021.[4]
References edit
- ^ a b c d e f g h i j k l m n "Oxymetazoline Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2021. Retrieved 10 November 2021.
- ^ a b Velpandian, Thirumurthy (29 February 2016). Pharmacology of Ocular Therapeutics. Springer. p. 172. ISBN 978-3-319-25498-2.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1247. ISBN 978-0857114105.
- ^ "Oxymetazoline nasal Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 January 2021. Retrieved 10 November 2021.