Wikipedia

User:Mr. Ibrahem/Nitazoxanide

< User:Mr. Ibrahem
Mr. Ibrahem/Nitazoxanide
Clinical data
Pronunciationnye" ta zox' a nide[1]
Trade namesAlinia, Nizonide, others
AHFS/Drugs.comMonograph
MedlinePlusa603017
License data
Routes of
administration		By mouth
Drug classAntiprotozoal[2]
Legal status
Legal status
Pharmacokinetic data
Protein bindingNitazoxanide: ?
Tizoxanide: over 99%[3][4]
MetabolismRapidly hydrolyzed to tizoxanide[3]
Metabolitestizoxanide[3][4]
tizoxanide glucuronide[3][4]
Elimination half-life3.5 hours[5]
ExcretionKidney, bile duct, and fecal[3]
Identifiers
  • [2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate
Chemical and physical data
FormulaC12H9N3O5S
Molar mass307.28 g·mol−1
3D model (JSmol)
  • O=C(Nc1ncc(s1)[N+]([O-])=O)c2ccccc2OC(=O)C
  • InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17) checkY
  • Key:YQNQNVDNTFHQSW-UHFFFAOYSA-N checkY
  (verify)

Nitazoxanide, sold under the brand name Alinia among others, is a medication that is used to treat various protozoa and parasitic worms.[3][1] This includes cryptosporidiosis, giardiasis, amebiasis, isosporiasis, and certain tapeworms, flukes, and roundworms.[2] It is taken by mouth.[2]

Common side effects include abdominal pain, nausea, headache, and abnormally colored urine.[2] Safety in pregnancy is unclear.[2] It is a thiazolide and is believed to work by blocking pyruvate ferredoxin oxidoreductase.[1]

Nitazoxanide was approved for medical use in the United States in 2002.[2] It was approved as a generic medication in 2020.[6] In the United States 6 tablets of 500 mg costs about 240 USD as of 2021.[7] Research is ongoing as of 2021 with respect to its use for influenza.[8]

References edit

  1. ^ a b c "Nitazoxanide". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.
  2. ^ a b c d e f g h i "Nitazoxanide Monograph for Professionals". Drugs.com. Archived from the original on 5 August 2020. Retrieved 13 November 2021.
  3. ^ a b c d e f g "Alinia- nitazoxanide tablet Alinia- nitazoxanide powder, for suspension". DailyMed. Archived from the original on 20 March 2021. Retrieved 13 February 2021.
  4. ^ a b c Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther. 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.
  5. ^ Nitazoxanide. National Center for Biotechnology Information. Archived from the original on 6 March 2016. Retrieved 3 January 2016. {{cite encyclopedia}}: |work= ignored (help)
  6. ^ "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 26 January 2021. Retrieved 13 February 2021.
  7. ^ "Nitazoxanide Prices and Nitazoxanide Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 13 November 2021.
  8. ^ "Nitazoxanide". SPS - Specialist Pharmacy Service. 14 January 2016. Archived from the original on 13 November 2021. Retrieved 13 November 2021.
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