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 | |
| Clinical data | |
|---|---|
| Pronunciation | nye sol' di peen[1] |
| Trade names | Sular, Baymycard, Syscor, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a696009 |
| Routes of administration | By mouth |
| Drug class | Calcium channel blocker (dihydropyridine)[2] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 4–8% |
| Protein binding | >99% |
| Metabolism | CYP3A4 |
| Elimination half-life | 7–12 hours |
| Excretion | 70–80% via urine |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C20H24N2O6 |
| Molar mass | 388.414 g·mol−1 |
| 3D model (JSmol) | |
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Nisoldipine, sold under the brand name Sular, is a medication used to treat high blood pressure.[2] It may be used by itself or with other medications.[2] It is taken by mouth.[2]
Common side effects include swelling, headache, palpitations, nausea, and rash.[2] Other side effects may include angina, low blood pressure], and allergic reactions.[2] While use during pregnancy is not well studied, risk is low.[3] It is a calcium channel blocker (CCB) of the dihydropyridine class.[2] It works by resulting in vasodilation of arteries.[1]
Nisoldipine was patented in 1975 and approved for medical use in 1990.[4] It was approved in the United States in 1995.[2] It is available as a generic medication.[1] In the United States it costs about 54 USD per month.[5]
References
edit- ^ a b c "Nisoldipine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.
- ^ a b c d e f g h i j "Nisoldipine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 13 November 2021.
- ^ "Nisoldipine (Sular) Use During Pregnancy". Drugs.com. Archived from the original on 22 September 2021. Retrieved 13 November 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 464. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-12-04.
- ^ "Nisoldipine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 November 2021.