Clinical data | |
---|---|
Trade names | Viracept |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697034 |
License data |
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Routes of administration | By mouth |
Drug class | HIV protease inhibitor[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | Uncertain; increases when taking with food[2] |
Protein binding | >98% |
Metabolism | Liver by CYP including CYP3A4 and CYP2C19 |
Elimination half-life | 3.5–5 hours |
Excretion | feces (87%), urine (1–2%) |
Identifiers | |
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Chemical and physical data | |
Formula | C32H45N3O4S |
Molar mass | 567.79 g·mol−1 |
3D model (JSmol) | |
Melting point | 349.94 °C (661.89 °F) |
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Nelfinavir (NFV), sold under the brand name Viracept,is a medication used to treat HIV/AIDS.[1] It is used together with other medications.[1] It is not a first line treatment.[1] It is taken by mouth.[1]
Common side effects include diarrhea, nausea, and rash.[1] Other side effects may include high blood sugar and changes in body fat.[1] While there is no specific harm with us in pregnancy, better options are available.[3] It is an HIV protease inhibitor.[1]
Nelfinavir was patented in 1992 and approved for medical use in 1997.[4] While it was approved in Europe in 1998, this was later withdrawn.[5] In the United States it costs about 1,200 USD per month as of 2021.[6]
References
edit- ^ a b c d e f g h i j "Nelfinavir Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 12 November 2021.
- ^ "Viracept (nelfinavir mesylate) Tablets and Oral Powder, for Oral Use. Full Prescribing Information" (PDF). ViiV Healthcare Company. Research Triangle Park, NC 27709. Archived (PDF) from the original on 4 March 2016. Retrieved 23 November 2015.
- ^ "Nelfinavir (Viracept) Use During Pregnancy". Drugs.com. Archived from the original on 23 January 2021. Retrieved 12 November 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 510. ISBN 9783527607495. Archived from the original on 2021-05-24. Retrieved 2021-04-24.
- ^ "Viracept". Archived from the original on 23 October 2020. Retrieved 12 November 2021.
- ^ "Nelfinavir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.