User:Mr. Ibrahem/Nedocromil

Mr. Ibrahem/Nedocromil
Clinical data
Trade names	Alocril, Tilade, Rapitil, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601243
Routes of; administration	Inhalation, eye drops
Drug class	Mast cell stabilizer
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	89%
Metabolism	Not metabolized
Elimination half-life	~3.3 hours
Excretion	Excreted unchanged
Identifiers
	IUPAC name 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid;
Chemical and physical data
Formula	C19H17NO7
Molar mass	371.345 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC;
	InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) ; Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N ;
	(verify)

Nedocromil, sold under the brand name Alocil among others, is a medication used to treat allergic conjunctivitis.^[1] It is used as an eye drop.^[2]

Common side effects include headache, irritated eyes, and stuffy nose.^[1] There is no evidence of harm with use in pregnancy.^[3] It is a mast cell stabilizer, which decreases the release of histamine.^[2]

Nedocromil was approved for medical use in the United States in 1999.^[1] In the United States it costs about 230 USD for a 5 ml bottle.^[4]

References edit

^ ^a ^b ^c ^d ^e ^f "Nedocromil (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 12 November 2021.
^ ^a ^b Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Archived from the original on 20 May 2014. Retrieved 17 May 2013.
^ "Nedocromil ophthalmic (Alocril) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 12 November 2021.
^ "Nedocromil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f "Nedocromil (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 12 November 2021.

[PI2021-2] Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Archived from the original on 20 May 2014. Retrieved 17 May 2013.

[3] "Nedocromil ophthalmic (Alocril) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 12 November 2021.

[4] "Nedocromil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.

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