User:Mr. Ibrahem/Naratriptan

Mr. Ibrahem/Naratriptan
Clinical data
Trade names	Amerge, Naramig, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601083
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Drug class	Triptan
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	74%
Metabolism	Liver
Elimination half-life	5-8 hours
Excretion	Kidney
Identifiers
	IUPAC name N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide;
Chemical and physical data
Formula	C17H25N3O2S
Molar mass	335.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(NC)CCc3ccc1c(c(c[nH]1)C2CCN(C)CC2)c3;
	InChI InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3 ; Key:AMKVXSZCKVJAGH-UHFFFAOYSA-N ;
	(verify)

Naratriptan, sold under the brand name Amerge among others, is a medication used to treat migraine headaches.^[1] It is not used preventatively.^[1] It is taken by mouth.^[1]

Common side effects include numbness, nausea, sleepiness, and tiredness.^[1] Other side effects may include coronary vasospasm, stroke, high blood pressure, serotonin syndrome, anaphylaxis, and medication overuse headache.^[1] Safety in pregnancy is unclear.^[3] It is a triptan which works as a selective 5-HT₁ receptor agonist.^[1]

Naratriptan was patented in 1987 and approved for medical use in 1997.^[4] It is available as a generic medication.^[2] In the United Kingdom 6 tablets costs the NHS about £3 as of 2021.^[2] This amount in the United States is about 11 USD.^[5]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Naratriptan Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 11 November 2021.
^ ^a ^b ^c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 501. ISBN 978-0857114105.
^ "Naratriptan (Amerge) Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 12 November 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 978-3-527-60749-5. Archived from the original on 2020-10-23. Retrieved 2021-10-24.
^ "Naratriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 31 October 2016. Retrieved 11 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Naratriptan Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 11 November 2021.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 501. ISBN 978-0857114105.

[3] "Naratriptan (Amerge) Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 12 November 2021.

[Fis2006-4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 978-3-527-60749-5. Archived from the original on 2020-10-23. Retrieved 2021-10-24.

[5] "Naratriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 31 October 2016. Retrieved 11 November 2021.

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