Wikipedia

User:Mr. Ibrahem/Micafungin

< User:Mr. Ibrahem
Mr. Ibrahem/Micafungin
Clinical data
Trade namesMycamine
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • C
Routes of
administration		Intravenous
Drug classAntifungal (echinochandin)[1]
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding99.8%
MetabolismVia catechol-O-methyltransferase pathway
Elimination half-life11–17 hours
Excretion40% feces, <15% urine
Identifiers
  • {5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-2-carbamoyl-1-hydroxyethyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[(4-{5-[4-(pentyloxy)phenyl]-1,2-oxazol-3-yl}benzene)amido]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl}oxidanesulfonic acid
Chemical and physical data
FormulaC56H71N9O23S
Molar mass1270.28 g·mol−1
  • InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26-,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1 checkY
  • Key:PIEUQSKUWLMALL-NFGJWQNFSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Micafungin, sold under the brand name Mycamine, is an antifungal medication used to treat or prevent severe candidiasis.[1] It may also be used for aspergillosis.[2] It is given by gradual injection into a vein.[1]

Common side effects include low white blood cells, low red blood cells, low potassium, low calcium, nausea, liver problems, and fever.[1] Other side effects may include anaphylaxis and kidney problems.[2] Safety in pregnancy is unclear.[3] It is an echinochandin which stops the production of beta-1,3-glucan, an essential component of fungal cell walls.[1]

Micafungin was approved for medical use in the United States in 2005 and Europe in 2008.[2][1] It is available as a generic medication.[4] It is on the World Health Organization's List of Essential Medicines.[5] In the United States 7 doses of 100 mg costs about 370 USD.[4] This amount in the United Kingdom costs about £2,000.[6]

References edit

  1. ^ a b c d e f g h "Mycamine". Archived from the original on 10 March 2021. Retrieved 18 November 2021.
  2. ^ a b c "Micafungin Monograph for Professionals". Drugs.com. Archived from the original on 24 July 2021. Retrieved 18 November 2021. Cite error: The named reference "AHFS2021" was defined multiple times with different content (see the help page).
  3. ^ "Micafungin (Mycamine) Use During Pregnancy". Drugs.com. Archived from the original on 23 January 2021. Retrieved 18 November 2021.
  4. ^ a b "Micafungin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 November 2021.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 632. ISBN 978-0857114105.
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