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User:Mr. Ibrahem/Methylergometrine

< User:Mr. Ibrahem
Mr. Ibrahem/Methylergometrine
Clinical data
Trade namesMethergine, Ergotrate, others
Other namesMethylergometrine maleate, methylergonovine,[1] methylergobasin,[1] d-lysergic acid 1-butanolamide
AHFS/Drugs.comMonograph
MedlinePlusa601077
Pregnancy
category
  • Contraindicated
Routes of
administration		Injection into a muscle or vein, by mouth[2]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
MetabolismLiver
Elimination half-life30–120 min
ExcretionMostly bile
Identifiers
  • N-[(2S)-1-Hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8β-carboxamide
Chemical and physical data
FormulaC20H25N3O2
Molar mass339.439 g·mol−1
3D model (JSmol)
Melting point172 °C (342 °F)
Solubility in waterinsoluble mg/mL (20 °C)
  • CC[C@@H](CO)NC(=O)[C@@H]2/C=C1/c3cccc4N\C=C(\C[C@H]1N(C)C2)c34
  • InChI=1S/C20H25N3O2/c1-3-14(11-24)22-20(25)13-7-16-15-5-4-6-17-19(15)12(9-21-17)8-18(16)23(2)10-13/h4-7,9,13-14,18,21,24H,3,8,10-11H2,1-2H3,(H,22,25)/t13-,14+,18-/m1/s1 ☒N
  • Key:UNBRKDKAWYKMIV-QWQRMKEZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Methylergometrine, sold under the brand name Methergine among others, is a medication used to treat post partum bleeding due to poor uterine contraction.[2] It is less preferred to oxytocin for this use.[1] It has also been used to check if people have angina due to coronary vasospasms.[2] It is used by injection into a muscle, by mouth, or less commonly by injection into a vein.[1][2]

Common side effects include high blood pressure, seizures, headache, nausea, and low blood pressure.[2] Other side effects may include ringing in the ears, numbness, confusion, and chest pain.[1] Caution is advised in those who have liver problems, kidney problems, or poor blood flow.[1] Safety in pregnancy or breastfeeding is unclear and thus in these situations use is not advised.[1][2] It is in the family of medicines known as oxytocics and ergot alkaloids.[2][4]

Methylergometrine is derived from ergometrine which was initially isolated from the fungus Claviceps purpurea in 1935.[5] In the United States it is available as a generic medication and costs about 68 USD for 6 tablets of 0.2 mg as of 2020.[6] In the developing world this amount costs about 0.13 USD as of 2015 while the injectable form is about 0.18 USD per dose.[7][8]

References edit

  1. ^ a b c d e f g h "METHYLERGOMETRINE injectable - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 2 September 2020.
  2. ^ a b c d e f g "Methylergonovine Maleate Monograph for Professionals". Drugs.com. Archived from the original on 20 September 2016. Retrieved 2 September 2020.
  3. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 December 2020. Retrieved 2 September 2020.
  4. ^ Clinical Pharmacology During Pregnancy. Academic Press. 2012. p. 310. ISBN 978-0-12-386008-8. Archived from the original on 2021-08-29. Retrieved 2020-09-02.
  5. ^ Briggs, Gerald G.; Nageotte, Michael (2009). Diseases, Complications, and Drug Therapy in Obstetrics: A Guide for Clinicians. ASHP. p. 264. ISBN 978-1-58528-337-8. Archived from the original on 2021-08-29. Retrieved 2020-09-02.
  6. ^ "Methergine Prices and Methergine Coupons". GoodRx. Archived from the original on 16 August 2016. Retrieved 30 October 2020.
  7. ^ "Single Drug Information – International Medical Products Price Guide". Archived from the original on 28 August 2021. Retrieved 30 October 2020.
  8. ^ "Single Drug Information – International Medical Products Price Guide". Archived from the original on 28 August 2021. Retrieved 30 October 2020.
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