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User:Mr. Ibrahem/Mefenamic acid

< User:Mr. Ibrahem
Mr. Ibrahem/Mefenamic acid
Clinical data
Pronunciationmef" e nam' ik[1]
Trade namesPonstel, Ponstan, others
AHFS/Drugs.comMonograph
MedlinePlusa681028
Pregnancy
category
  • AU: C
Routes of
administration		By mouth, suppositories
Drug classNSAIDs[1]
Legal status
Legal status
  • AU: S2 (Pharmacy medicine)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability90%
Protein binding>90%
MetabolismLiver (CYP2C9)
Elimination half-life2 hours
ExcretionUrine (52–67%), faeces (20–25%)
Identifiers
  • 2-(2,3-dimethylphenyl)aminobenzoic acid
Chemical and physical data
FormulaC15H15NO2
Molar mass241.290 g·mol−1
3D model (JSmol)
  • O=C(O)c2c(Nc1cccc(c1C)C)cccc2
  • InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) checkY
  • Key:HYYBABOKPJLUIN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Mefenamic acid is a nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat mild to moderate pain including painful periods.[2][3] Other uses include for inflammation.[3] Such use is recommended for less than a week.[2] It is taken by mouth.[2]

Common side effects include abdominal pain, heartburn, vomiting, kidney problems, fluid retention, and rashes.[2] Other serious side effects may include cardiovascular disease, allergic reactions, stomach ulcers, hemolytic anemia, liver problems, and heart failure.[2][1][4] Use is not recommended in the last third of pregnancy and during breastfeeding.[2] Mefenamic acid works by decreasing the production of prostaglandin by the enzyme cyclooxygenase.[1]

Mefenamic acid was approved for medical use in the United States in 1967.[2] It is available as a generic medication.[3] In the United Kingdom 100 tablets of 250 mg costs the NHS about 23 pounds as of 2020.[3] This amount in the United States costs about 135 USD.[5] It is not widely used in the United States due to concerns of relatively greater side effects compared to some other NSAIDs.[1][4]

References edit

  1. ^ a b c d e f "Mefenamic Acid". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Retrieved 8 October 2020.
  2. ^ a b c d e f g "Mefenamic Acid Monograph for Professionals". Drugs.com. Retrieved 8 October 2020.
  3. ^ a b c d BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 1182. ISBN 9780857113658.
  4. ^ a b Aronson, Jeffrey K. (2009). Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier. p. 334. ISBN 978-0-08-093294-1.
  5. ^ "Mefenamic Acid Prices, Coupons & Savings Tips". GoodRx. Retrieved 8 October 2020.
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