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| Clinical data | |
|---|---|
| Pronunciation | lan ree' oh tide[1] |
| Trade names | Somatuline |
| Other names | Lanreotide acetate |
| AHFS/Drugs.com | Monograph |
| License data |
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| Pregnancy category |
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| Routes of administration | Intramuscular, subcutaneous |
| Drug class | Somatostatin analogue[2] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Approximately 80% |
| Protein binding | 78% |
| Metabolism | In GI tract |
| Elimination half-life | 2 hours (immediate release) 5 days (sustained release) |
| Excretion | Mostly biliary |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C54H69N11O10S2 |
| Molar mass | 1096.33 g/mol 1156.380 g/mol (acetate) g·mol−1 |
| 3D model (JSmol) | |
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Lanreotide, sold under the brand name Somatuline, is a medication used to treat acromegaly, neuroendocrine tumors such as carcinoid, and thyroid tumors.[2] In acromegaly it is used when other treatments are not effective.[3] It is given by injection under the skin or into a muscle.[2]
Common side effects include diarrhea, abdominal pain, nausea, gallstones, joint pain, and pain at the site of injection.[3] Other side effects may include pancreatitis, high blood sugar, low blood sugar, and liver problems.[1] It is a somatostatin analogue and works by decreasing levels of growth hormone, insulin, and glucagon.[2][1]
Lanreotide was approved for medical use in the United States in 2007.[3] In the United Kingdom it costs the NHS about £550 at a dose of 60 mg per month as of 2021.[2] This amount in the United States costs about 6,100 USD.[4]
References edit
- ^ a b c "Lanreotide". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 20 November 2021. Retrieved 20 November 2021.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 993. ISBN 978-0857114105.
- ^ a b c d "Lanreotide Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 20 November 2021.
- ^ "Somatuline Depot Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 April 2021. Retrieved 20 November 2021.