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| Clinical data | |
|---|---|
| Trade names | GlucaGen, Baqsimi, Gvoke, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682480 |
| License data | |
| Pregnancy category |
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| Routes of administration | Nasal, intravenous (IV), intramuscular injection (IM), subcutaneous injection |
| Drug class | Glycogenolytic[2] |
| Legal status | |
| Legal status | |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C153H225N43O49S |
| Molar mass | 3482.747314 g·mol−1 |
| 3D model (JSmol) | |
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  (what is this?) (verify) | |
Glucagon is a medication and hormone.[4] As a medication it is used to treat low blood sugar, beta blocker overdose, calcium channel blocker overdose, and those with anaphylaxis who do not improve with epinephrine.[2] It is given by injection into a vein, muscle, or under the skin.[2] A version given in the nose is also available.[6]
Common side effects include vomiting.[2] Other side effects include low blood potassium and low blood pressure.[4] It is not recommended in people who have a pheochromocytoma or insulinoma.[2] Use in pregnancy has not be found to be harmful to the baby.[7] Glucagon is in the glycogenolytic family of medications.[2] It works by causing the liver to break down glycogen into glucose.[2]
Glucagon was approved for medical use in the United States in 1960.[2] It is on the World Health Organization's List of Essential Medicines.[8] The wholesale cost in the developing world is about US$25.75 a dose.[9] In the United Kingdom that dose costs the NHS about £11.52.[4] In the United States the wholesale cost of a dose is US$247.32.[10] It is a manufactured form of the glucagon hormone.[2]
References edit
- ^ a b "Glucagon Use During Pregnancy". Drugs.com. 16 October 2019. Archived from the original on 27 December 2016. Retrieved 16 May 2020.
- ^ a b c d e f g h i j k "Glucagon". The American Society of Health-System Pharmacists. Archived from the original on 26 December 2016. Retrieved 8 December 2016.
- ^ "GlucaGen Hypokit 1 mg - Summary of Product Characteristics (SmPC)". (emc). 15 June 2015. Archived from the original on 12 November 2020. Retrieved 16 May 2020.
- ^ a b c d British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 487. ISBN 9780857111562.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 10 December 2020. Retrieved 16 September 2020.
- ^ Commissioner, Office of the (24 March 2020). "FDA approves first treatment for severe hypoglycemia that can be administered without an injection". FDA. Archived from the original on 17 May 2020. Retrieved 16 May 2020.
- ^ "Glucagon (GlucaGen) Use During Pregnancy". www.drugs.com. Archived from the original on 27 December 2016. Retrieved 27 December 2016.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Glucagon". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
- ^ "NADAC as of 2016-12-21 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Archived from the original on 24 December 2016. Retrieved 27 December 2016.