 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Foscavir |
| Other names | Foscarnet sodium, phosphonomethanoic acid, dihydroxyphosphinecarboxylic acid oxide |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601144 |
| License data | |
| Pregnancy category |
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| Routes of administration | Intravenous |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | 14–17% |
| Elimination half-life | 3.3–6.8 hours |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | CH3O5P |
| Molar mass | 126.004 g·mol−1 |
| 3D model (JSmol) | |
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Foscarnet, sold under the brand name Foscavir, is an antiviral used to treat cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV).[2] Primarily this is those who are immunocompromised such as due to HIV/AIDS.[2] It is given by injection into a vein.[3]
Common side effects include fever, nausea, low red blood cells, kidney problems, seizures, and headache.[2] Other side effects may include electrolyte abnormalities, prolonged QT, and anaphylaxis.[2] Safety in pregnancy is unclear.[2] It acts similar to pyrophosphate as a viral DNA polymerase inhibitor.[2]
Foscarnet was approved for medical use in the United States in 1991.[4][2] In the United Kingdom 6 grams costs the NHS about £120 as of 2021.[3] This amount in the United States cost about 4,800 USD.[5]
References edit
- ^ "Foscavir- foscarnet sodium injection, solution". DailyMed. 23 April 2020. Archived from the original on 26 March 2021. Retrieved 6 November 2020.
- ^ a b c d e f g h i "Foscarnet Monograph for Professionals". Drugs.com. Archived from the original on 15 November 2021. Retrieved 13 December 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 678. ISBN 978-0857114105.
- ^ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2021-04-29.
- ^ "Foscarnet Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 21 April 2021. Retrieved 13 December 2021.