Clinical data | |
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Pronunciation | /droʊˈpɛrIdɔːl/ |
Trade names | Inapsine, Droleptan, Dridol, others |
AHFS/Drugs.com | Monograph |
Pregnancy category |
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Routes of administration | Intravenous, intramuscular[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Metabolism | Liver |
Onset of action | < 10 min[1] |
Elimination half-life | 2.3 hours |
Duration of action | Up to 12 hrs[1] |
Identifiers | |
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Chemical and physical data | |
Formula | C22H22FN3O2 |
Molar mass | 379.435 g·mol−1 |
3D model (JSmol) | |
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Droperidol is a medication used to prevent and treat nausea and vomiting including that due to chemotherapy.[1] It has also been used for sedative in those who are agitated and during anesthesia and for migraines.[1][2] It is given by injection into a vein or muscle.[1] Onset is within 10 minutes with a maximum effect up to 30 minutes.[1] Effects may last up to 12 hours.[1]
Common side effects include low blood pressure, movement disorders, fast heart rate, and sleepiness.[1] Other concerns include QT prolongation, and neuroleptic malignant syndrome.[1] Safety during pregnancy and breastfeeding is unclear.[3] It is in the butyrophenone family of medication and works by blocking dopamine receptors.[4]
Droperidol came into medical use in 1967.[5] It is available as a generic medication.[4] In 2001 the company making it stopped doing so.[5] It historically has been inexpensive.[5] Availability improved in 2019 as a new manufacturer entered the market.[6] In the United Kingdom 2.5 mg of injectable solution costs the NHS about 4 pounds as of 2020.[4]
References edit
- ^ a b c d e f g h i j k "Droperidol Monograph for Professionals". Drugs.com. Archived from the original on 26 March 2016. Retrieved 13 October 2020.
- ^ a b Thomas, MC; Musselman, ME; Shewmaker, J (February 2015). "Droperidol for the treatment of acute migraine headaches". The Annals of pharmacotherapy. 49 (2): 233–40. doi:10.1177/1060028014554445. PMID 25416184.
- ^ "Droperidol (Inapsine) Use During Pregnancy". Drugs.com. Archived from the original on 29 October 2020. Retrieved 13 October 2020.
- ^ a b c BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 452. ISBN 9780857113658.
- ^ a b c Richards, JR; Schneir, AB (May 2003). "Droperidol in the emergency department: is it safe?". The Journal of emergency medicine. 24 (4): 441–7. doi:10.1016/s0736-4679(03)00044-1. PMID 12745049.
- ^ "Droperidol Is Back (and Here's What You Need to Know)". ACEP Now. Archived from the original on 25 September 2020. Retrieved 13 October 2020.