 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Trusopt, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a602022 |
| Routes of administration | Topical (eye drops) |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Protein binding | ~33% |
| Elimination half-life | 4 months |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C10H16N2O4S3 |
| Molar mass | 324.43 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Dorzolamide, sold under the brand name Trusopt among others, is medications used to treat high pressure inside the eye including glaucoma.[2] It is used as an eye drop.[2] Effects begin within three hours and lasts for at least eight hours.[2] It is also available as the combination dorzolamide/timolol.[2]
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision.[2] Serious side effects include Steven Johnson syndrome.[2] Those allergic to sulfonamides may be allergic to dorzolamide.[2][3] Use is not recommended in pregnancy or breastfeeding.[3] It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humour.[2]
Dorzolamide was approved for medical use in the United States in 1994.[2] It is available as a generic medication.[3] A 5 milliliter bottle in the United Kingdom costs the NHS less than £2 as of 2019.[3] In the United States the wholesale cost of this amount is about US$7.10.[4] In 2017, it was the 281st most commonly prescribed medication in the United States, with more than one million prescriptions.[5][6]
References edit
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 24 August 2019. Retrieved 9 September 2020.
- ^ a b c d e f g h i "Dorzolamide Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 27 March 2019. Retrieved 26 March 2019.
- ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1148. ISBN 9780857113382.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Dorzolamide Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 23 May 2020. Retrieved 11 April 2020.