Clinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a601001 |
Pregnancy category |
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Routes of administration | Intravenous, by mouth |
Drug class | 5-HT3 receptor blocker[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 69 to 77% |
Elimination half-life | 8.1 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C19H20N2O3 |
Molar mass | 324.380 g·mol−1 |
3D model (JSmol) | |
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Dolasetron, sold under the brand name Anzemet, is a medication used for postoperative and chemotherapy-induced nausea and vomiting.[1][2] Other uses may include gastroenteritis and hyperemesis gravidarum.[1] It does not work for motion sickness.[1] It is taken by mouth; and less commonly by injection into a vein.[2]
Common side effects include headache, tiredness, dizziness, and diarrhea.[1] Other side effects may include QT prolongation and anaphylaxis.[1][2] While there is no evidence of harm in pregnancy, such use is not well studied.[3] It is a 5-HT3 receptor blocker.[1]
Dolasetron was patented in 1986 and approved for medical use in 1997.[4] It is on the World Health Organization's List of Essential Medicines.[5] It is available as a generic medication.[1] In the United States it costs about 75 USD per dose.[6] Some versions have been discontinued in the United States.[7]
References
edit- ^ a b c d e f g h i j "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 26 December 2021.
- ^ a b c d e "Dolasetron Monograph for Professionals". Drugs.com. Archived from the original on 22 January 2021. Retrieved 26 December 2021.
- ^ "Dolasetron (Anzemet) Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 26 December 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2020-11-28.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "Anzemet Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 26 December 2021.
- ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Archived from the original on 22 March 2021. Retrieved 26 December 2021.