User:Mr. Ibrahem/Ciclopirox

Mr. Ibrahem/Ciclopirox
Clinical data
Trade names	Loprox, Penlac, others
AHFS/Drugs.com	Monograph
MedlinePlus	a604021
Pregnancy; category	B;
Routes of; administration	Topical (applied as a nail lacquer, skin cream or shampoo)
Drug class	Antifungal
Legal status
Legal status	US: ℞-only; Rx-only (CA);
Pharmacokinetic data
Bioavailability	<5% with prolonged use
Protein binding	94 to 97%
Elimination half-life	1.7 hours
Identifiers
	IUPAC name 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one;
Chemical and physical data
Formula	C12H17NO2
Molar mass	207.269 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1/C=C(\C=C(/N1O)C2CCCCC2)C;
	InChI InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3 ; Key:SCKYRAXSEDYPSA-UHFFFAOYSA-N ;
	(verify)

Ciclopirox (CPX) is an antifungal used to treat ringworm, tinea versicolor, candidiasis of the skin, seborrheic dermatitis, and fungal infection of the nail.^[1] It is applied as a gel, cream, or nail polish.^[2]

It is generally well tolerated.^[2] Common side effects include mild redness and burning.^[1] Other side effects may include allergic reactions.^[2] While there is no evidence of harm in pregnancy, such use has not been well studied.^[3] Its mechanism of action differs from other antifungals.^[2]

Ciclopirox was approved for medical use in the United States in 1982.^[1] It is available as a generic medication.^[4] In the United States a bottle of 6.6 ml of the nail polish costs about 16 USD.^[4]

References edit

^ ^a ^b ^c ^d ^e ^f "Ciclopirox Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 4 January 2022.
^ ^a ^b ^c ^d Gupta, Aditya K.; Mays, Rachel R.; Folley, Kelly A. (2019). "42. Topical antifungal agents". In Wolverton, Stephen E.; Wu, Jashin J. (eds.). Comprehensive Dermatologic Drug Therapy (4th ed.). Elsevier. p. 487. ISBN 978-0-323-61211-1. Archived from the original on 2021-10-09. Retrieved 2021-10-07.
^ "Ciclopirox topical Use During Pregnancy". Drugs.com. Archived from the original on 21 October 2020. Retrieved 4 January 2022.
^ ^a ^b "Ciclopirox Prices and Ciclopirox Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 4 January 2022.

[AHFS2022-1] ^ ^a ^b ^c ^d ^e ^f "Ciclopirox Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 4 January 2022.

[Wolv2019-2] Gupta, Aditya K.; Mays, Rachel R.; Folley, Kelly A. (2019). "42. Topical antifungal agents". In Wolverton, Stephen E.; Wu, Jashin J. (eds.). Comprehensive Dermatologic Drug Therapy (4th ed.). Elsevier. p. 487. ISBN 978-0-323-61211-1. Archived from the original on 2021-10-09. Retrieved 2021-10-07.

[3] "Ciclopirox topical Use During Pregnancy". Drugs.com. Archived from the original on 21 October 2020. Retrieved 4 January 2022.

[GX2022-4] "Ciclopirox Prices and Ciclopirox Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 4 January 2022.

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