 | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | IL-1β |
| Clinical data | |
| Trade names | Ilaris |
| Other names | ACZ885, ACZ-885 |
| AHFS/Drugs.com | Monograph |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Intravenous, subcutaneous |
| Legal status | |
| Legal status |
|
| Chemical and physical data | |
| Formula | C6452H9958N1722O2010S42 |
| Molar mass | 145200 g·mol−1 |
  (what is this?) (verify) | |
Canakinumab, sold under the brand name Ilaris, is a medication used to treat periodic fever syndromes, gout, and Still's disease.[2] The periodic fever syndromes it is used in include cryopyrin-associated periodic syndromes (CAPS), familial mediterranean fever (FMF), tumour necrosis factor receptor associated periodic syndrome (TRAPS), and HIDS/MKD.[2] It is given by injection under the skin.[2]
Common side effects include infections of the nose and throat, abdominal pain, nausea, and injection-site reactions.[2][3] Other side effects may include infections.[3] Those on the medication should not receive live vaccines.[3] It is a monoclonal antibody that binds to and blocks interleukin-1 beta. [2]
Canakinumab was approved for medical use in the United States and Europe in 2009.[4][2] In the United Kingdom 150 mg costs the NHS about £9,900 as of 2021.[5] This amount in the United States is about 17,500 USD.[6]
References edit
- ^ Rondeau JM, Ramage P, Zurini M, Gram H (2015). "The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β". mAbs. 7 (6): 1151–60. doi:10.1080/19420862.2015.1081323. PMC 4966334. PMID 26284424.
- ^ a b c d e f g h "Ilaris". Archived from the original on 11 June 2020. Retrieved 29 December 2021.
- ^ a b c d "Ilaris- canakinumab injection, powder, lyophilized, for solution Ilaris- canakinumab injection, solution". DailyMed. 14 September 2019. Archived from the original on 4 August 2020. Retrieved 16 June 2020.
- ^ "Canakinumab Monograph for Professionals". Drugs.com. Archived from the original on 4 July 2018. Retrieved 29 December 2021.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 890. ISBN 978-0857114105.
- ^ "Ilaris Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 27 January 2021. Retrieved 29 December 2021.