User:Mr. Ibrahem/Cabazitaxel

Mr. Ibrahem/Cabazitaxel
Clinical data
Trade names	Jevtana
Other names	XRP-6258
AHFS/Drugs.com	Monograph
MedlinePlus	a611009
License data	EU EMA: by INN; US DailyMed: Cabazitaxel; US FDA: Cabazitaxel;
Pregnancy; category	AU: D; ;
Routes of; administration	Intravenous
Drug class	Taxane
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(Acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate;
Chemical and physical data
Formula	C45H57NO14
Molar mass	835.944 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC;
	InChI InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35, ; Key:BMQGVNUXMIRLCK-OAGWZNDDSA-N ;
	(what is this?) (verify)

Cabazitaxel, sold under the brand name Jevtana, is a medication used to treat prostate cancer.^[2] Specifically it is used for metastatic castration-resistant prostate cancer who have failed other treatment.^[2] It is given by injection into a vein.^[2]

Common side effects include low red blood cells, low white blood cells, low platelets, and diarrhea.^[2] Other side effects may include allergic reactions and kidney problems.^[3] It is a taxane which interferes with microtubules.^[1]

Cabazitaxel was approved for medical use in the United States in 2010 and Europe in 2011.^[3]^[2] In the United Kingdom 60 mg costs the NHS about £3,700 as of 2021.^[4] This amount in the United States costs about 12,700 USD.^[5]

References

^ ^a ^b "Cabazitaxel". NCI Drug Dictionary. U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. 2011-02-02. Archived from the original on 2015-04-25. Retrieved 2021-02-16.
^ ^a ^b ^c ^d ^e ^f ^g "Jevtana". Archived from the original on 1 May 2021. Retrieved 29 December 2021.
^ ^a ^b "Cabazitaxel Monograph for Professionals". Drugs.com. Archived from the original on 2 November 2020. Retrieved 28 December 2021.
^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 968. ISBN 978-0857114105.
^ "Jevtana Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 29 December 2021.

[NCI2021-1] "Cabazitaxel". NCI Drug Dictionary. U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. 2011-02-02. Archived from the original on 2015-04-25. Retrieved 2021-02-16.

[EPAR2021-2] ^ ^a ^b ^c ^d ^e ^f ^g "Jevtana". Archived from the original on 1 May 2021. Retrieved 29 December 2021.

[AHFS2021-3] "Cabazitaxel Monograph for Professionals". Drugs.com. Archived from the original on 2 November 2020. Retrieved 28 December 2021.

[BNF81-4] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 968. ISBN 978-0857114105.

[5] "Jevtana Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 29 December 2021.

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