User:Mr. Ibrahem/Bromfenac

Mr. Ibrahem/Bromfenac
Clinical data
Trade names	Bromday, Xibrom, Prolensa, Yellox, others
AHFS/Drugs.com	Monograph
MedlinePlus	a611018
License data	EU EMA: by INN; US DailyMed: Bromfenac;
Routes of; administration	Eye drops
Drug class	NSAID
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Protein binding	99.8%
Metabolism	CYP2C9
Metabolites	Lactam, others
Elimination half-life	1.4 hours in aqueous humour
Excretion	82% urine, 13% faeces
Identifiers
	IUPAC name 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid;
Chemical and physical data
Formula	C15H12BrNO3
Molar mass	334.169 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	284 to 286 °C (543 to 547 °F) (bromfenac sodium·1.5H2O)
	SMILES O=C(c1ccc(Br)cc1)c2cccc(c2N)CC(=O)O;
	InChI InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19) ; Key:ZBPLOVFIXSTCRZ-UHFFFAOYSA-N ;
	(verify)

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) which is used for pain and inflammation after cataract surgery.^[1] It is used as an eye drop twice per day for two weeks.^[1]

Common side effects include red eyes, itchy eyes, and headache.^[1] Other side effects may include slower wound healing, bleeding, and keratitis.^[1] It works by blocking the production of prostaglandins.^[1]

Bromfenac was approved for medical use in the United States in 2005.^[1] It is available as a generic medication.^[2] In the United States 1.7 ml of 0.09% solution costs about 51 USD as of 2021.^[2] In the United Kingdom 5 ml of the solution costs the NHS 8.5 pounds.^[3]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Bromfenac Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 17 July 2021.
^ ^a ^b "Bromfenac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 26 May 2020. Retrieved 17 July 2021.
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1241. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Bromfenac Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 17 July 2021.

[GX2021-2] "Bromfenac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 26 May 2020. Retrieved 17 July 2021.

[BNF80-3] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1241. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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