Clinical data | |
---|---|
Trade names | Nexletol, Nilemdo |
Other names | ESP-55016, ETC-1002 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a620020 |
License data | |
Pregnancy category |
|
Routes of administration | By mouth |
Drug class | Adenosine triphosphate-citrate lyase blocker[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 99.3%[3] |
Metabolism | Glucuronidation |
Elimination half-life | 21±11 hrs |
Excretion | 70% urine, 30% feces |
Identifiers | |
| |
Chemical and physical data | |
Formula | C19H36O5 |
Molar mass | 344.492 g·mol−1 |
3D model (JSmol) | |
| |
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Bempedoic acid, sold under the brand name Nexletol among others, is a medication used to treat high cholesterol.[3][1] It is unclear if it effects life expectancy or disability as of 2021.[3] It is used together with a statin.[1] It is taken by mouth.[3]
Common side effects include high uric acid, pain in arms or legs, and [low red blood cells]].[1] Other side effects may include liver problems and tendon rupture.[3] Use in pregnancy may harm the baby.[3] It works by blocking an enzyme in the liver called adenosine triphosphate-citrate lyase, which is involved in making cholesterol.[1]
Bempedoic acid was approved for medical use in the United States and Europe in 2020.[1][3] In the United Kingdom 4 weeks of medication costs the NHS about £55 as of 2021.[4] This amount in the United States costs about 360 USD.[5] It is also available as the combination of bempedoic acid/ezetimibe.[6]
References
edit- ^ a b c d e f g h i j "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Nilemdo 180mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 4 September 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.
- ^ a b c d e f g h "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 221. ISBN 978-0857114105.
- ^ "Nexletol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 January 2022.
- ^ "Bempedoic Acid Monograph for Professionals". Drugs.com. Retrieved 9 January 2022.