 | |
| Clinical data | |
|---|---|
| Trade names | Iopidine |
| Other names | Apraclonidine hydrochloride |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608005 |
| Routes of administration | Eye drop |
| Drug class | α2 adrenergic receptor activator[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 98.7% |
| Elimination half-life | 8 hours |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C9H10Cl2N4 |
| Molar mass | 245.11 g·mol−1 |
| 3D model (JSmol) | |
| |
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| (verify) | |
Apraclonidine, sold under the brand name Iopidine, is a medication used to treat glaucoma.[1] Specifically it is used short term for open-angle glaucoma not controlled with other treatments.[1] It may also be used to prevent increased intraocular pressure in those undergoing certain types of laser eye surgery.[2] It is used as an eye drop.[1]
Common side effects include red eyes, itchiness, dry mouth, dilated pupil, runny nose, and dry eyes.[1] Other side effects may include allergic reactions, palpitations, depression, and dizziness.[1] Safety in pregnancy is unclear.[1] It is primarily an α2 adrenergic receptor activator and works by decreasing aqueous humour production.[1][2]
Apraclonidine was approved for medical use in the United States in 1987.[1] It is available as a generic medication.[3] In the United States 5 ml costs about 26 USD as of 2022.[3] In the United Kingdom this amount costs the NHS about £11.[2]
References edit
- ^ a b c d e f g h i j k "Apraclonidine Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 15 January 2022.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1232. ISBN 978-0857114105.
- ^ a b "Apraclonidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 July 2016. Retrieved 15 January 2022.