 | |
| Clinical data | |
|---|---|
| Other names | Ethiofos |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Intravenous |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | complete |
| Elimination half-life | 8 minutes |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C5H15N2O3PS |
| Molar mass | 214.22 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Amifostine, sold under the brand name Ethyol, is a medication used to prevent toxicity related to chemotherapy and radiotherapy.[1] Specifically it is used to prevent kidney toxicity from cisplatin and parotid gland damage from head and neck radiation.[1] It is given by injection into a vein.[1]
Common side effects include low blood pressure and nausea.[1] Other side effects may include severe skin rashes, allergic reactions, and low calcium.[1] Use during pregnancy may harm the baby.[1] It is a cytoprotective agent.[2]
Amifostine was approved for medical use in the United States in 1995.[1] In the United States a 500 mg vial costs about 480 USD as of 2022.[3]
References edit
- ^ a b c d e f g h i "DailyMed - ETHYOL- amifostine injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 14 January 2022.
- ^ "Amifostine Monograph for Professionals". Drugs.com. Archived from the original on 7 April 2021. Retrieved 14 January 2022.
- ^ "Amifostine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 January 2022.