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| Clinical data | |
|---|---|
| Trade names | Nesina, Vipidia Kazano, Vipidomet (with metformin) Oseni, Incresync (with pioglitazone) |
| Other names | Alogliptin benzoate, SYR-322 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a613026 |
| License data |
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| Pregnancy category |
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| Routes of administration | By mouth |
| Drug class | DPP-4 inhibitor (gliptin)[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Protein binding | 20% |
| Metabolism | Limited, liver (CYP2D6- and 3A4-mediated) |
| Elimination half-life | 12–21 hours |
| Excretion | Kidney (major) and fecal (minor) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C18H21N5O2 |
| Molar mass | 339.399 g·mol−1 |
| 3D model (JSmol) | |
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Alogliptin, sold under the brand names Nesina and Vipidia among others, is a medication used to treat type 2 diabetes.[1] It is a second line treatment used together with diet and exercise.[3] Effects on the risk of heart disease are unclear.[1] It is taken by mouth.[2]
Common side effects include runny nose, headache, and upper respiratory tract infection.[1] Other side effects may include pancreatitis, heart failure, anaphylaxis, liver problems, and low blood sugar.[1] Safety in pregnancy is unclear.[1] It is a DPP-4 inhibitor (gliptin), which works by increasing insulin secretion from the pancreas.[1][2]
Alogliptin was approved for medical use in the United States and Europe in 2013.[1][4] In the United Kingdom 4 weeks costs the NHS about £27 as of 2021.[2] This amount in the United States is about 90 USD.[5] It is also available as a combination medication with metformin or pioglitazone.[3]
References
edit- ^ a b c d e f g h i j "DailyMed - ALOGLIPTIN tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 10 November 2021. Retrieved 14 January 2022.
- ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 734. ISBN 978-0857114105.
- ^ a b "Alogliptin Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 14 January 2022.
- ^ "Vipidia". Archived from the original on 16 November 2021. Retrieved 14 January 2022.
- ^ "Alogliptin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 January 2022.