Clinical data | |
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Pronunciation | /ˌæfəmɛˈlænoʊtaɪd/ |
Trade names | Scenesse |
Other names | [Nle4,D-Phe7]α-MSH; NDP-α-MSH; NDP-MSH; Melanotan; Melanotan-1; Melanotan I; EPT1647; CUV1647; |
AHFS/Drugs.com | Monograph |
License data | |
Pregnancy category |
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Routes of administration | Subcutaneous implant |
Drug class | MC1-R activator[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Elimination half-life | 30 minutes[2] |
Identifiers | |
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Chemical and physical data | |
Formula | C78H111N21O19 |
Molar mass | 1646.874 g·mol−1 |
3D model (JSmol) | |
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Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent skin damage from the sun in erythropoietic protoporphyria.[1] It increases the amount of light exposure before pain occurs.[1] It is used as an implant under the skin.[1]
Common side effects include nausea, cough, tiredness, sleepiness, increased skin pigmentation, and skin irritation.[1] It should not be used in people with kidney or liver problems.[4] Safety in pregnancy is unclear.[1] It is a melanocortin 1 receptor (MC1-R) activator, which increases the amount of dark pigment produced by the skin.[1][4]
Afamelanotide was approved for medical use in Europe in 2015 and the United States in 2019.[5][4] As of 2022 it is not currently available in the United Kingdom.[6] In the United States it costs 49,000 USD per implant as of 2022.[7]
References
edit- ^ a b c d e f g h i "DailyMed - SCENESSE- afamelanotide implant". dailymed.nlm.nih.gov. Archived from the original on 13 January 2022. Retrieved 13 January 2022.
- ^ Cite error: The named reference
EMA2017
was invoked but never defined (see the help page). - ^ "Afamelanotide (Scenesse) Use During Pregnancy". Drugs.com. 3 January 2020. Archived from the original on 2 January 2020. Retrieved 26 January 2020.
- ^ a b c "Scenesse". Archived from the original on 19 November 2019. Retrieved 13 January 2022.
- ^ "Afamelanotide (Topical) Monograph for Professionals". Drugs.com. Archived from the original on 27 January 2021. Retrieved 13 January 2022.
- ^ "Afamelanotide". SPS - Specialist Pharmacy Service. 28 January 2016. Archived from the original on 14 September 2019. Retrieved 13 January 2022.
- ^ "Scenesse Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 3 March 2021. Retrieved 13 January 2022.