 | |
| Clinical data | |
|---|---|
| Trade names | Soriatane, Neotigason, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601010 |
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Retinoid[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 60% |
| Protein binding | >99.9% |
| Metabolism | Hepatic |
| Elimination half-life | 49 hours |
| Excretion | Faeces & urine |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C21H26O3 |
| Molar mass | 326.436 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Acitretin, sold under the trade name Soriatane among others, is a medication used to treat psoriasis, discoid lupus, ichthyosis, and Darier's disease.[2][1] Use is only recommended in severe disease were other treatments are not effective.[2] It is taken take by mouth.[2] Full benefits may take 2 to 3 months.[2]
Common side effects include inflammation of the lips, hair loss, itchiness, dry eyes, joint pain, and thinning of the skin.[2] Other side effects may include suicidal thoughts, liver problems, easy sunburns, and benign intracranial hypertension.[1] Use during, or the two years prior to pregnancy may harm the baby.[2] It is in the retinoid family of medications.[1] It is believed to work by prevention retinol being converted to retinoic acid.[2]
Acitretin was approved for medical use in the United States in 1996.[2] It is available as a generic medication.[3] In the United States a month of treatment costs about 90 USD.[3] In the United Kingdom this amount costs the NHS about 25 pounds as of 2021.[1] Following us a person should not giving blood for at least three years due to the risk of birth defects in those who receive the blood.[1]
References edit
- ^ a b c d e f g BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1327. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ a b c d e f g h i j "Acitretin Monograph for Professionals". Drugs.com. Archived from the original on 6 March 2021. Retrieved 18 July 2021.
- ^ a b "Acitretin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 September 2016. Retrieved 18 July 2021.