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Kattesh V. Katti
Kattesh Varihanumanthacharya Katti (born November 11, 1956) is an Indian born American chemist and Curators’ Distinguished Professor of Radiology, Physics, Biological Engineering and Medical Pharmacology and Physiology and Senior Research Scientist at the University of Missouri Research Reactor, University of Missouri, Columbia, Missouri, USA. He is also the Director of the Institute of Green nanotechnology at the same institution. He is best known for his work in the areas of bioconjugation chemistry, radiopharmaceutical sciences for SPECT imaging and radiotherapy, biocompatible nanoparticles for molecular imaging and therapy through nanomedicine. He is globally renowned as the father of ‘Green Nanotechnology’ where his inventions have paved way for the industrial scale production of a myriad of nanoparticles through electron-rich plant-based phytochemicals, thus achieving zero carbon footprint in the overall production scheme [1] . He is the inventor of a family of trigonal (or trimeric) amino acids (commonly referred to as ‘Katti Peptides’) which have found widespread applications in nanobiomedicine, biomaterials and allied biomedical sciences [2]. A prolific author and patent holder who has received many awards, including the George Hevesy Medal Award—the premier international award of excellence in radioanalytical and nuclear chemistry—named after the Nobel Prize winner George de HEVESY [3].
Education and academic career
editKatti attended high school at the K.E.Boards School in Dharwad, India and graduated in 1970.[4] He received his Bachelor of Science degree from the J.S.S. College, affiliated to Karnatak University in Dharwad, India, in 1977 and earned a Masters in Science Education in chemistry from the Regional College of Education in Mysore, affiliated to the National Council of Education and Research, New Delhi, India, in 1979. In 1984, he received a Ph.D. in chemistry from the Indian Institute of Science (IISc) where he worked with his mentor S. S. Krishnamurthy [5]. At IISc, Katti’s graduate work used main group family of heterocyclic compounds referred to as phosphazenes. He performed synthesis of various monomeric and polymeric phosphazenes as well as probed the mechanism of substitution reactions at the P(V) center in these main group compounds. He was an Alexander von Humboldt (AvH) postdoctoral research fellow at the University of Gottingen, Germany, where he worked with Professor Hebert W. Roesky on cyclometallophosphazenes—a family of quasi-aromatic heterocycles—which he discovered through insertion of transition metals within the cyclic phosphazenes [6] . He used single crystal X-ray crystallography and NMR spectroscopy extensively to study the structures and ring-opening polymerization processes of this new class of hybrid inorganic-organometallic compounds. He became a faculty in 1990 and currently serves as a distinguished Curators’ Professor in Radiology and Physics at the University of Missouri with a joint appointment as a Senior Research Scientist at the University of Missouri Research Reactor (MURR) [7].
Current Research
editKatti’s research interests include main group chemistry, materials science, bioconjugation chemistry, biomaterials, medicinal chemistry, radiopharmaceutical sciences, nanotechnology, green nanotechnology and nanomedicine. He has moved from one research frontier to another many times throughout his career with the sole of objective of translating research findings into valued added products for saving human lives. He has done that repeatedly in his quest toward rational drug design through innovative discoveries in new chemical, radiometal or nanoparticulate conjugates for improving drug efficacy, drug delivery and drug tolerance. Katti is regarded as a pioneer in the area of radioactive gold nanoparticles as he has demonstrated their applications in in vivo imaging, cancer therapy and in theranostics. Katti Peptides: All living things contain carbon, mostly sp3-bonded in tetrahedral geometry, in the form of macromolecules, including proteins, lipids, nucleic acids, and carbohydrates. Probing the structures of the three-dimensional essential constituents of proteins and DNA in the living system has had a profound impact in understanding the origin and evolution of life. In this context, Katti’s 1994 discovery of trigonal (or trimeric) amino acids is a major innovation as it paves way for the rational drug design through interconnecting fields of three-dimensional peptide and protein structural biology, the genetic basis of diseases, and many more fields. Katti’s discovery of trigonal (or trimeric) amino acids, which are rare, have been referred to as the ‘Katti Peptides’ by the National Academy of Inventors [8].[9] [10] More recently, in his continuous efforts toward clinical translation aimed at achieving his lifelong objectives from ‘bench to bedside’ through his discoveries, Katti has applied nanotechnology to ancient Ayurvedic medicine practiced in India for over 5000 thousand years. His invention of a new medical modality, called as ‘Nano Ayurvedic Medicine’, has received approval for its use in various products by the US Patents and Trademarks office [11] . Katti’s inventions have resulted in several products for human use for treating cancers, infections and various diseases and disorders. Katti attributes his success to a great balance in his formal education in chemistry, physics and mathematics. The St Louis Academy of Science—one of the oldest scientific academies of the world—when it awarded the '2007 Outstanding St. Louis Scientist Fellows Award', the Academy's literature cited: ‘Katti was selected to receive this award in part because of the international recognition he has received for his contributions to chemistry, physics, nanoscience and radiochemistry—a rare feat to be distinguished in all of these fields simultaneously" and praised Katti's discoveries in the development of gold and silver nanoparticles for applications in nanomedicine [12]
Awards and achievements
editKatti is the author of more than 350 scientific articles, reviews and peer reviewed scientific conference publications and is listed as an inventor on at least 30 patents and over 150 scientific inventions [13] . Katti has co-founded 4 companies within the nanotechnology, nanomedicine and green nanotechnology spaces for the development of the next generation of health and hygiene products. Katti has mentored more than 75 graduate students, postdocs, and visiting scholars. He serves on the editorial advisory boards of several scientific journals.
Katti is a fellow of the American Association for the Advancement of Science (AAAS) [14] [15]. He is a fellow of the Royal Society of Chemistry (FRSC). He is also a fellow of the National Academy of Inventors which recognized his inventions of a group of trigonal (trimeric) amino acids as the ‘Katti Peptides’ in its award citation [16]. He is a fellow of the Academy of Science - St. Louis—one of the oldest scientific societies of the world [12].
Among other awards and recognitions, Katti is the recipient of the George Hevesy Medal Award (2015)—a premier international award of excellence in radioanalytical and nuclear chemistry—named after George de HEVESY, the Nobel Prize winner [3]. This coveted prize is awarded to an individual in recognition of excellence through outstanding, sustained career achievements in the fields of pure as well as applied nuclear and radiochemistry, applications to nuclear analytical chemistry. He was cited as the ‘Father of Green Nanotechnology (2007)’ by the Nobel Prize winner Norman Borlaug, in recognition of his pioneering efforts in the production of gold nanoparticles using electron-rich phytochemicals from Soya beans and various plant species [14]. Dr. Katti, for the first time, demonstrated that by submersing gold salts in water and then adding soybeans, gold nanoparticles were generated which are non-toxic for applications in molecular imaging and therapy of cancer and other diseases. He is a recipient of the WHOs WHO Marquis “Albert Nelson Marquis Lifetime Achievement Award” (2019) Cite error: A <ref> tag is missing the closing </ref> (see the help page).
[17]
. This work has created a new field of holistic medicine which is now referred to as ‘Nano Ayurvedic Medicine [18]. He has received the RMIT Foundation Award (2016) in recognition of his pioneering research in Green Nanotechnology, Nano-Ayurvedic Medicine and Nano Medicine. He was recognized as ‘One of 25 Most Influential Scientists In Molecular Imaging in the World’ by RT Image for his discovery of the production of biocompatible radioactive gold nanoparticles for theranostics applications in molecular imaging and therapy of cancer and other diseases [19][20]. Katti is the first immigrant American to receive the ‘Outstanding Missourian Award’ in 2008, the citation states: “The Missourian Award is an acknowledgement of the most accomplished citizen of the state of Missouri and the Nation (http://missourianaward.org/) [21]. He received this State’s highest award in recognition of his pioneering research and groundbreaking discoveries spanning the areas of cancer diagnostics/therapy and Nanomedicine.
Kattesh Katti received the 2006 Gauss Professorship Award from the Göttingen Academy of Sciences, Germany—the fourth US scientist to receive this highly prestigious international award. He received the 2007 Outstanding St. Louis Scientist Fellows Award. Katti was inducted into this prestigious academy as a ‘Fellow’ in 2007. The Academy's literature called it "a rare feat to be distinguished in all chemistry, physics, nanoscience and radiochemistry—all of these fields simultaneously" and praised Katti's discoveries in the development of gold and silver nanoparticles for applications in nanomedicine [12].
Kattesh Katti received the highest academic honor from the University of Missouri, the Distinguished Curators’ Professorship’ award (2009)—in recognition of his internationally acclaimed groundbreaking discoveries as well as his sustained outstanding research and scholarship contributions in nanoscience and nanomedicine [7]. He received the University of Missouri’s 50th Alumni Association Award in 2017 for his sustained and outstanding contributions in research, teaching, economic development and service [22]
. He was also honored with an Endowed Chair Professorship in Cancer Research entitled ‘Margaret Proctor Mulligan Professor in Cancer Research’ with a citation: “Katti is internationally known for developing gold nanoparticles that can detect breast cancer and other forms of cancer, potentially much earlier than current imaging methods”. More recently, United Nations/International Atomic Energy Agency (IAEA) chose Katti as the Global Subject Expert & Consultant in Green Nano-Radiopharmaceuticals with an official assignment in Thailand. He has represented the United States in research missions in his pioneering field of Nanoradiopharmaceuticals at the United Nations/IAEA in 2015-2020. Kattesh Katti is a scholar of the Alexander von Humboldt from Germany (1985-1987) [6]. In 2014, Sam Higginbottom Institute of Agriculture Technology and Sciences (SHIATS)—One of India’s 100-year old premier Universities—honored Katti with a Doctor of Science Degree (DSc) and established an Institute named after him: ‘Kattesh Katti Institute of Green Nanotechnology and Agri Nanotechnology’ [23]. He has also received the Doctor of Science Degree (DSc) from his alma mater, the Karnataka University in 2009. Kattesh Katti’s research discoveries have been extensively cited by popular media including the British Broadcasting Corporation, HowStuffWorks, Huffingtonpost and numerous print and television media throughout the world [24] [25] [26]
Personal life
editKatti and his wife, Kavita, have one daughter, Sumidha, and one son, Nahush. Sumidha, with a Master of Public Health degree, works as a healthcare revenue review consultant in San Francisco, CA. Nahush, with a degree in Industrial Engineering, works for a healthcare consulting company in the Chicago, IL area
References
edit- ^ "Green Nanotechnology' where his inventions paved way for the industrial scale production of a myriad of nanoparticles through electron-rich plant-based phytochemicals, thus achieving zero carbon footprint in the overall production scheme: Soybeans as a Phytochemical Reservoir for the Production and Stabilization of Biocompatible Gold Nanoparticles; Katti et al: Small; Volume4, Issue9; September 2008; Pages 1425-1436".
- ^ "He invented a family of trigonal (or trimeric) amino acids in the early 90s (commonly referred to as 'Katti Peptides') which have found widespread applications in nanobiomedicine, biomaterials and allied biomedical sciences. Douglas E. Berning, Kattesh V. Katti, et al."Chemical and Biomedical Motifs of the Reactions of Hydroxymethylphosphines with Amines, Amino Acids, and Model Peptides"Journal of the American Chemical Society 1999 121 (8), 1658-1664; DOI: 10.1021/ja9827604".
- ^ a b "The George Hevesy Medal Award is the premier international award of excellence in radioanalytical and nuclear chemistry. It is named after George de HEVESY (1885-1966) who received the Nobel Prize for Chemistry in 1943 for his work on the use of isotopes as tracers in the study of chemical processes. Since the inception of this international award in 1968, there are 43 award recipients as of 2019".
- ^ "At its centenary celebrations, the Alma mater management of K.E.Boards School in Dharwad, India, selected Kattesh V. Katti to be one of the 50 top achievers in the school's hundred year old history. Other high achievers included, artists, engineers, medical doctors, musicians, policy makers, military generals among many other areas of human endeavors".
- ^ "The Indian Institute of Science (IISc) was established in 1909 by a visionary partnership between the industrialist Jamsetji Nusserwanji Tata, the Mysore royal family and the Government of India. Over the last 111 years, IISc has become India's premier institute for advanced scientific and technological research and education. IISc's reputation and pre-eminence ensures that it attracts the best young faculty members trained in the best laboratories around the world. In 2018, IISc was selected as an Institution of Eminence (IoE) by the Government of India, and it consistently figures among the top Indian institutions in world university rankings".
- ^ a b "The Alexander von Humboldt Foundation (German: Alexander von Humboldt-Stiftung) is a foundation established by the government of the Federal Republic of Germany and funded by the Federal Foreign Office, the Federal Ministry of Education and Research, the Federal Ministry for Economic Cooperation and Development as well as other national and international partners; it promotes international academic cooperation between excellent scientists and scholars from Germany and from abroad".
- ^ a b "A Curators' Distinguished Professorship is the highest and most prestigious academic rank awarded by the Board of Curators of the University of Missouri. It is awarded to a select few "outstanding scholars with established reputations." Each Curators' Distinguished Professor becomes a "resource of the entire University and should be expected to contribute to the entire University through such activities as giving lectures on other campuses and engaging in teaching and research across divisional lines."".
- ^ "Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles".
- ^ "MU Scientist and Inventor Advances the Study of Nanomedicine Kattesh V. Katti elected as a Fellow in the National Academy of Inventors for contributions to nanomedicine and green nanotechnology".
- ^ "Katti Peptides Citation by the National Academy of Inventors" (PDF).
- ^ "NANO AYURVEDIC MEDICINE - Trademark Details".
- ^ a b c "The Fellows of the Academy of Science – St. Louis is a prestigious association of St. Louis scientists and engineers of national and international reputation. Many Academy Fellows are recipients of the Academy of Science – St. Louis Outstanding Scientists Awards, including the Peter H. Raven Lifetime Achievement Award, Science Leadership Award (Individual), James B. Eads Award, Trustees Award, Academy Fellows Award and George Engelmann Interdisciplinary Award".
- ^ "Dr. Kattesh Katti google scholar profile".
- ^ "MU scientist and inventor advances the study of nanomedicine".
- ^ "Six MU Faculty Members Named as Fellows of the American Association for the Advancement of Science".
- ^ "National Academy of Inventors Names 170 New Fellows; The 2014 class brings total NAI Fellows to 414 distinguished academic innovators".
- ^ "MU Radiology Professor Named India's Person of the Year in Science".
- ^ "New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine – Pre-Clinical and Pilot Human Clinical Investigations".
- ^ "Katti, who was recently recognized by rt Image magazine as one of the 25 most influential people in radiology: rt Image; September 8, 2008, vol 21, NO. 36".
- ^ "MU scientists go green with gold, distribute environmentally friendly nanoparticles".
- ^ ""Now, therefore, be it resolved that we, the members of the Missouri House of Representatives, Ninety-fourth General Assembly, join unanimously to applaud the well-deserved selection of Dr. Kattesh Katti as an Outstanding Missourian, and to extend to him this legislative body's most heartfelt welcome to the state capitol on March 4, 2008, for special recognition as a guest in the House Chamber ; and Be it further resolved that the Chief Clerk of the Missouri House of Representatives be instructed to prepare a properly inscribed copy of this resolution in honor of Outstanding Missourian Kattesh V. Katti, M.D., of Columbia, Missouri"" (PDF).
- ^ "The Faculty-Alumni Awards began in 1968 to recognize the achievements of faculty and alumni. This award focuses attention not only on these outstanding persons and their accomplishments, but also on the vital relationship between faculty and alumni in promoting the best interests of the University of Missouri. Through the awards program, the Mizzou Alumni Association expresses its appreciation for these individuals and their service to higher education".
- ^ "Sam Higginbottom University of Agriculture, Technology and Sciences".
- ^ "Newsnight broadcast a special programme on cancer".
- ^ "How is green nanotechnology being used?".
- ^ "Green Tea And Gold Compound 'Could Treat Prostate Cancer' Says Study".
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