User:Louisajb/UCL-1530

Louisajb/UCL-1530
Identifiers
CAS Number	172998-23-1;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL446445;
ChemSpider	8732891;
	InChI InChI=1S/C43H46N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30H,1-6,11-12,27-28,31-33H2/p+2/b44-40-,45-41+ Key: SXDHPHPRCINSFL-XUQYBVARSA-P;
	SMILES C1CCCCCNC2=C3C=CC=CC3=[N+](CC3=CC=C(CC4=CC=C(C[N+]5=CC=C(NCCCC1)C1=CC=CC=C51)C=C4)C=C3)C=C2;
Properties
Chemical formula	C43H48N42+
Molar mass	620.9 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

UCL-1530 is a bis-quinolinium cyclophane analogue of dequalinium. It has been investigated for its ability to block the Ca²⁺-activated K⁺ (SK_Ca) channels in the sympathetic neurones of rats and guinea pig hepatocytes.^[1]^[2]

References edit

^ Dunn, P.M.; Benton, D.C.H.; Rosa, J. Campos; Ganellin, C.R.; Jenkinson, D.H. (1996). "Discrimination between subtypes of apamin-sensitive Ca²⁺- activated K⁺ channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530". British Journal of Pharmacology. 117 (1): 35–42. doi:10.1111/j.1476-5381.1996.tb15151.x. PMC 1909372. PMID 8825340.{{cite journal}}: CS1 maint: PMC format (link)
^ Campos Rosa, Joaquin; Galanakis, Dimitrios; Piergentili, Alessandro; Bhandari, Kalpana; Ganellin, C. Robin; Dunn, Philip M.; Jenkinson, Donald H. (2000). "Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes: Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca²⁺-Activated K⁺ Channel". Journal of Medicinal Chemistry. 43 (3): 420–431. doi:10.1021/jm9902537. PMID 10669569.

Identifiers

CAS Number	172998-23-1
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL446445
ChemSpider	8732891
InChI InChI=1S/C43H46N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30H,1-6,11-12,27-28,31-33H2/p+2/b44-40-,45-41+ Key: SXDHPHPRCINSFL-XUQYBVARSA-P
SMILES C1CCCCCNC2=C3C=CC=CC3=[N+](CC3=CC=C(CC4=CC=C(C[N+]5=CC=C(NCCCC1)C1=CC=CC=C51)C=C4)C=C3)C=C2
Properties
Chemical formula	C₄₃H₄₈N₄²⁺
Molar mass	620.9 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references