The Gene for DR6 is 78,450 bases long and is found on the 6th chromosome. This is transcribed into a 655 amino acid chain weighing 71.8 kDa. Post transcriptional modifications of this protein include glycosylation on the aspargenines at the 82, 141, 252, 257, 278, and 289 amino acid locations Mungall AJ (et. al.). The DR6 is an alpha helical integral membrane receptor protein that shows evidence that it has something to do with the inhibition of blood vessels forming on tumors which would allow them to grow larger. Oddly enough the free serum levels of this DR6 are congruently heightened with anti- cell death factors in patients that have later stage ovarian cancer (Sasaroli et al.). Death receptor 6 gets a chemical message and starts a signaling pathway that causes apoptosis also know as cell death to occur (P, Daniel T., et. al.).
Martin, K., Jitka, Z., Doubravska, L., & Lanislav, A. (2009, October). Functional analysis of the posttranslational modifications of the death receptor 6. Retrieved November, 2016, from http://www.sciencedirect.com/science/article/pii/S016748890900189X
P, Daniel T., T. Wieder, I. Strum, and K. Schulze-Osthoff. "The Kiss of Death: Promises and Failures of Death Receptors and Ligands in Cancer Therapy." National Center for Biotechnology Information. U.S. National Library of Medicine, July 2001. Web. Nov. 2016.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, et. Al. “The DNA sequence and analysis of human chromosome 6.” National Center for Biotechnology Information. U.S. National Library of Medicine, Oct. 2003 retrieved Nov. 2016
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