User:Korrektheit 1/sandbox

Submission declined on 26 November 2023 by WikiOriginal-9 (talk).

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Declined by WikiOriginal-9 5 months ago. Last edited by Citation bot 41 days ago. Reviewer: Inform author.

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Zinkfinger-Inhibitoren edit

Zinkfinger-Inhibitoren oder Zink-Auswerfer sind Stoffe, die mit Zinkfingern in Wechselwirkung treten und bewirken, dass diese ihr Zink an ihrem Bindungsort freigeben. Dadurch wird die Struktur der Polypeptidkette gestört, und die Zinkfinger verlieren ihre Wirksamkeit. Dadurch können sie nicht mehr ihre Aufgaben erfüllen, die mit verschiedenen Zellfunktionen verbunden sind. Dies geschieht normalerweise durch Bindung an die Zinkbindungsstelle. Da Zinkfinger bekanntermaßen an verschiedenen Prozessen wie der Steuerung von m-RNA, der umgekehrten Transkription, dem Schutz von synthetisierter viraler DNA, der Hemmung der Transkription und den frühen Integrationsprozessen beteiligt sind, kann die Blockierung ihrer Funktion erhebliche Auswirkungen auf die Funktion von Zellen oder Viren haben.^[1]

Einzelnachweise: edit

^ Porteus, Matthew (2008), "Design and Testing of Zinc Finger Nucleases for Use in Mammalian Cells", Chromosomal Mutagenesis, Methods in Molecular Biology, vol. 435, Totowa, NJ: Humana Press, pp. 47–61, doi:10.1007/978-1-59745-232-8_4, ISBN 978-1-58829-899-7, PMID 18370067, retrieved 2023-11-26

[1] Porteus, Matthew (2008), "Design and Testing of Zinc Finger Nucleases for Use in Mammalian Cells", Chromosomal Mutagenesis, Methods in Molecular Biology, vol. 435, Totowa, NJ: Humana Press, pp. 47–61, doi:10.1007/978-1-59745-232-8_4, ISBN 978-1-58829-899-7, PMID 18370067, retrieved 2023-11-26

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