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High throughput biology has many definitions, including high throughput screening. High throughput screening (HTS) is used to detect and find drugs in a system through the use of many tests and research. This is how most drug discoveries are made today, as it screens for different properties and structures in what is being tested. Using this method has been used in the discovery of the drug sorafenib (Nexavar) which is an indication of cancer. High throughput screening for this was completed in 1994. Following three trials of testing for this drug, it was found to have anti-angiogenic effects on certain cancers, especially thyroid cancer[1]. Another discovery made using high throughput screening is maraviroc, which is an HIV entry inhibitor. It slows the process and prevents HIV from being able to enter human cells. High throughput screening of this drug was completed in 1997[2].
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- ^ Hautier G. Finding the needle in the haystack: Materials discovery and design through computational ab initio high-throughput screening. Computational Materials Science. 2019;163:108-116. doi:10.1016/j.commatsci.2019.02.040
- ^ Maraviroc. AHFS Consumer Medication Information. September 2019:1. http://search.ebscohost.com/login.aspx?direct=true&AuthType=shib&db=l0h&AN=78170261&site=eds-live. Accessed October 25, 2019